Results 111 to 120 of about 36,138 (257)

USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy

Cell Death and Disease, 2023
The spindle assembly checkpoint (SAC) is an essential mechanism that ensures the accurate chromosome segregation during mitosis, thus preventing genomic instability.
Diana Campos-Iglesias, Julia M. Fraile, Gabriel Bretones, Alejandro A. Montero, Elena Bonzon-Kulichenko, Jesús Vázquez, Carlos López-Otín, José M. P. Freije   +7 more
doaj   +1 more source

Molecular basis of APC/C regulation by the spindle assembly checkpoint

Nature, 2016
In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter cell inherits an identical set of chromosomes. The SAC coordinates the correct attachment of sister chromatid kinetochores to the mitotic spindle with ...
C. Alfieri, Leifu Chang, Ziguo Zhang, Jing Yang, S. Maslen, M. Skehel, D. Barford   +6 more
semanticscholar   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, Volume 16, Issue 6, Page 1213-1221, June 2026.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Insights into mitotic checkpoint by integrating CRISPR and RNAi

Molecular & Cellular Oncology, 2019
Our recent study of the mitotic checkpoint protein BUB1 (budding uninhibited by benzimidazoles 1) revealed several apparent BUB1 knock-out cell lines expressing low levels of BUB1 protein sufficient to support spindle assembly checkpoint activity.
Gang Zhang
doaj   +1 more source

Tracing the Pathway of Spindle Assembly Checkpoint Signaling [PDF]

Developmental Cell, 2001
Most current models of spindle assembly checkpoint signaling involve inhibition of the Cdc20-APC by Mad2 protein. Interestingly, a paper from Hongtao Yu and colleagues in this issue of Developmental Cell suggests that the Cdc20/APC can also be inhibited in a Mad2-independent manner by a complex of proteins that includes BubR1.
Gillett, Emily S., Sorger, Peter K.
openaire   +2 more sources

BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling

Current Biology, 2017
Summary The spindle assembly checkpoint (SAC) prevents premature sister chromatid separation during mitosis. Phosphorylation of unattached kinetochores by the Mps1 kinase promotes recruitment of SAC machinery that catalyzes assembly of the SAC effector ...
Katharina Overlack, Tanja Bange, Florian Weissmann, A. Faesen, S. Maffini, I. Primorac, Franziska Müller, J. Peters, A. Musacchio   +8 more
semanticscholar   +1 more source

TTK Overexpression: A Negative Prognostic Biomarker in Anaplastic Thyroid Carcinoma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Given threonine and tyrosine kinase (TTK)'s oncogenic role in various cancers and its understudied status in thyroid cancer, this study investigates TTK expression in thyroid lesions to assess its diagnostic and therapeutic potential. Methods We analyzed differential TTK expression levels using public datasets (n = 143) and clinical
Yan Guo, Zhidong Sun, Xiao Liu, Xianni Liu, Haiwen Chen, Menglan Zhang, Weibo Mao, Yuan Cao   +7 more
wiley   +1 more source

Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis

Scientific Reports, 2017
For faithful chromosome segregation, the formation of stable kinetochore–microtubule attachment and its monitoring by the spindle assembly checkpoint (SAC) are coordinately regulated by mechanisms that are currently ill-defined.
Masanori Ikeda, Kozo Tanaka
semanticscholar   +1 more source

Making Two out of One: Kinesin Motors Driving Plant Cell Division

Cytoskeleton, Volume 83, Issue 6, Page 384-393, June 2026.
ABSTRACT The Kinesin superfamily of microtubule dependent motors is present in all eukaryotes. Not all of the subfamilies are represented in all kingdoms, and the ones that are do not always show conserved functions. Tight control of the cytoskeleton is essential for proper progression and completion of mitosis and cytokinesis, and key functions are ...
Choy Kriechbaum, Sabine Müller
wiley   +1 more source