Results 111 to 120 of about 1,399,702 (223)
Precocious activation of APC/C-Cdh1 at pre-anaphase causes genome instability [PDF]
, 2008 Faithful chromosome segregation and thereby accurate gene transmission are crucial for all organisms. Until proper attachment of the mitotic spindle to the kinetochore is established, the ubiquitin ligase (E3) Cdc20-activated APC/C (anaphase promoting ...
Takanori Ohyoshi +6 more
core
The Spindle-Assembly Checkpoint, Aneuploidy, and Gastrointestinal Cancer [PDF]
New England Journal of Medicine, 2010 Genomic instability is a common occurrence in solid tumors, and it has long been conjectured that this process plays a causal role in cancer. The field of human molecular genetics has provided a means to test this hypothesis, fueled in part by the analysis of hereditary cancer-predisposition syndromes. Some of the first unequivocal support for the idea
openaire +2 more sources
A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling
eLife, 2017 The master spindle checkpoint kinase Mps1 senses kinetochore-microtubule attachment and promotes checkpoint signaling to ensure accurate chromosome segregation.
Zhejian Ji +4 more
doaj +1 more source
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source
Centriole assembly and the role of Mps1: defensible or dispensable?
Cell Division, 2011 The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C.
Fisk Harold A, Pike Amanda N
doaj +1 more source
Glia, Volume 74, Issue 11, November 2026.ATP1B2 and GLAST identify two astrocyte subpopulations in the hippocampus with distinct molecular signatures. Transcriptomic shifts during aging differ between both subpopulations. Aged ATP1B2+ astrocytes rewire their metabolism while double‐positive aged astrocytes display a reduced synaptogenic capability.
Lucía Casares‐Crespo +6 more
wiley +1 more source
Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex
Nature CommunicationsThe spindle assembly checkpoint (SAC) ensures mitotic exit occurs only after sister chromatid biorientation, but how this coordination is mechanistically achieved remains unclear.
Suruchi Sethi +6 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, Volume 20, Issue 10, Page 2490-2509, October 2026.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
The role of fission yeast nuclear actin-related protein in mitosis. [PDF]
, 2005 Nuclear actin-related proteins (Arps) have 20-30% identity to conventional actin and many are found to be in chromatin remodelling complexes. There are two families of chromatin remodelling complexes, one of which carries out covalent modification on ...
Minoda, A., Minoda, Akiko
core
Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity [PDF]
, 2007 Faithful chromosome segregation in mitosis requires the formation of a bipolar mitotic spindle with stably attached chromosomes. Once all of the chromosomes are aligned, the connection between the sister chromatids is severed by the cysteine protease ...
Erich A. Nigg +14 more
core +1 more source