Results 131 to 140 of about 1,399,702 (223)

Delayed Signaling in Mitotic Checkpoints: Biological Mechanisms and Modeling Perspectives

Biology
Time delays are intrinsic to mitotic regulation, particularly within the spindle assembly checkpoint (SAC) and the spindle position checkpoint (SPOC).
Bashar Ibrahim
doaj   +1 more source

Determinants of robustness in spindle assembly checkpoint signalling.

, 2013
The spindle assembly checkpoint is a conserved signalling pathway that protects genome integrity. Given its central importance, this checkpoint should withstand stochastic fluctuations and environmental perturbations, but the extent of and mechanisms ...
Geissen, E.M., Silke Hauf, Heinrich, S., Drewe, P., Stephanie Heinrich, Julia Kamenz, Trautmann, S., Christian Widmer, Jan Hasenauer, Hauf, S., Eva-Maria Geissen, Michael Knop, Knop, M., Philipp Drewe, Nicole Radde, Geissen, E., Kamenz, J., Hasenauer, J., Susanne Trautmann, Widmer, C., Radde, N.   +20 more
core   +1 more source

A minimal deterministic model reveals integration of spindle assembly and position checkpoints in mitosis

Scientific Reports
The spindle assembly checkpoint (SAC) and spindle position checkpoint (SPOC) are essential surveillance systems that ensure accurate chromosome segregation and proper spindle orientation during mitosis.
Bashar Ibrahim
doaj   +1 more source

Regulation der humanen Aurora-A Kinase und Identifikation potentieller Interaktionspartner [PDF]

, 2004
The error-free segregation of duplicated chromosomes during cell division is essential for the maintenance of an intact genome. This process is brought about by a highly dynamic bipolar array of microtubules, the mitotic spindle.
Kufer, Thomas
core  

Spindle Assembly Checkpoint

, 2006
细胞有丝分裂过程中,纺锤体组装检控点监控着染色体在赤道板的队列和向纺锤体两极的分离,确保动粒-微管的黏附和有丝分裂器的完整,使所有的染色体都置于赤道板并双极定向后才进入后期,保证遗传物质均等地分配给两个子代细胞。纺锤体组装检控点缺陷将导致非整倍体的出现,并与一些肿瘤的发生密切相关。现就近年来纺锤体组装检控点蛋白以及纺锤体组装检控点功能缺陷与肿瘤的关系方面的研究进展作一简要综述。Chromosomes aligned to the metaphase plate and segregated to the
鲍仕登, 欧赛英, 欧阳高亮
core  

A molecular analysis of the microtubule associated protein MAP65-1 [PDF]

, 2006
Microtubules (MTs) play important roles in various cellular processes including cell division, organelle movement and the determination of cellular morphology. The dynamics and organization of microtubules are regulated by microtubule associated proteins
Hsin Yu, Chang
core  

Signaling protein abundance modulates the strength of the spindle assembly checkpoint. [PDF]

Curr Biol, 2023
Jema S, Chen C, Humphrey L, Karmarkar S, Ferrari F, Joglekar AP.   +5 more
europepmc   +1 more source

Specialisation of meiotic kinetochores revealed through a synthetic spindle assembly checkpoint strategy. [PDF]

Elife
Koch LB, Ghosh T, Spanos C, Marston AL.
europepmc   +2 more sources

Network architecture determines delay robustness in the spindle assembly checkpoint. [PDF]

Sci Rep
Ibrahim B.
europepmc   +1 more source

Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer. [PDF]

Cancer Res Commun
Tabe C, Kumar R, Huang Y, Kruhlak MJ, Sharma AK, Shrestha RL, Thomas A.   +6 more
europepmc   +1 more source