Results 131 to 140 of about 36,138 (257)

Investigation into how mitotic spindle checkpoint function is compromised by Sv40 large T antigen.

, 2005
The viral oncoprotein Simian virus 40 large T antigen (LT) efficiently immortalises primary rodent cells and occasionally transforms them to tumourigenicity.
Lock, Rowena Lesley, Lock, R.L.
core  

A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

eLife, 2017
The master spindle checkpoint kinase Mps1 senses kinetochore-microtubule attachment and promotes checkpoint signaling to ensure accurate chromosome segregation.
Zhejian Ji, Haishan Gao, Luying Jia, Bing Li, Hongtao Yu   +4 more
doaj   +1 more source

Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

eLife, 2017
Chromosome instability (CIN) is deleterious to normal cells because of the burden of aneuploidy. However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a selective advantage. CIN can
F. Foijer, L. Albacker, B. Bakker, D. Spierings, Y. Yue, Stephanie Z. Xie, Stephanie H. Davis, Annegret Lutum-Jehle, D. Takemoto, B. Hare, Brinley F Furey, R. Bronson, P. Lansdorp, A. Bradley, P. Sorger   +14 more
semanticscholar   +1 more source

Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications

Small, Volume 22, Issue 33, 12 June 2026.
Particle shape is a key design parameter governing biological interactions. Advances in fabrication enable precise control over anisotropy and compartmentalization, allowing modulation of cellular uptake, transport, and biodistribution, ultimately enhancing therapeutic performance. ABSTRACT Polymer geometry is a primary determinant of physical behavior
Francisca G. Perfeito, Mariana B. Oliveira, João F. Mano   +2 more
wiley   +1 more source

Stochastic modelling of chromosomal segregation : errors can introduce correction

, 2014
Cell division is a complex process requiring the cell to have many internal checks so that division may proceed and be completed correctly. Failure to divide correctly can have serious consequences, including progression to cancer.
Roitershtein, Alexander, Matzavinos, Anastasios, Voller, Zachary, Liu, Sijia, Shtylla, Blerta, Chaplain, Mark A.J.   +5 more
core   +1 more source

The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo [PDF]

, 2002
In all eukaryotic organisms, the physical separation of two nascent cells must be coordinated with chromosome segregation and mitotic exit. In Saccharomyces cerevisiae and Schizosaccharomyces pombe this coordination depends on a number of genes that ...
Erich A. Nigg, Gartner, A., Nigg, EA, Glotzer, Michael, Gruneberg, Ulrike, Nigg, E. A., Michael Glotzer, Gartner, A, Gruneberg, U, Ulrike Gruneberg, Nigg, Erich A., Glotzer, M., Anton Gartner, Glotzer, M, Grüneberg, U., Gartner, Anton   +15 more
core   +1 more source

Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex

Nature Communications
The spindle assembly checkpoint (SAC) ensures mitotic exit occurs only after sister chromatid biorientation, but how this coordination is mechanistically achieved remains unclear.
Suruchi Sethi, Sabrina Ghetti, Verena Cmentowski, Teresa Benedetta Guerriere, Patricia Stege, Valentina Piano, Andrea Musacchio   +6 more
doaj   +1 more source

Spindle assembly checkpoint strength is linked to cell fate in the Caenorhabditis elegans embryo

Molecular Biology of the Cell, 2018
The spindle assembly checkpoint (SAC) is a conserved mitotic regulator that preserves genome stability by monitoring kinetochore–microtubule attachments and blocking anaphase onset until chromosome biorientation is achieved.
Abigail R. Gerhold, Vincent Poupart, J. Labbé, P. Maddox   +3 more
semanticscholar   +1 more source

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

Cell Proliferation, Volume 59, Issue 6, June 2026.
The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao, Yuqing Sun, Yutao Huang, Qinghang Meng, Xinhua Lin, Wei Wei, Xiaofang Tang   +6 more
wiley   +1 more source

Sustaining the Spindle Assembly Checkpoint to improve cancer therapy [PDF]

, 2016
To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite ...
Visconti, R, DELLA MONICA, ROSA, GRIECO, DOMENICO   +2 more
core   +1 more source