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The spindle assembly checkpoint
Current Opinion in Cell Biology, 1996The spindle assembly checkpoint monitors proper chromosome attachment to spindle microtubules and is conserved from yeast to humans. Checkpoint components reside on kinetochores of chromosomes and show changes in phosphorylation and localization as cells proceed through mitosis.
A D, Rudner, A W, Murray
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The Spindle Assembly and Spindle Position Checkpoints
Annual Review of Genetics, 2003▪ Abstract The mitotic spindle segregates chromosomes to opposite ends of the cell in preparation for cell division. Chromosome attachment to the spindle is monitored by the spindle assembly checkpoint, and at least in yeast cells, penetration of one spindle pole into the bud is monitored by the spindle position checkpoint.
Daniel J, Lew, Daniel J, Burke
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A quantitative systems view of the spindle assembly checkpoint [PDF]
EMBO Journal, 2009 The idle assembly checkpoint acts to delay chromosome segregation until all duplicated sister chromatids are captured by the mitotic spindle. This pathway ensures that each daughter cell receives a complete copy of the genome. The high fidelity and robustness of this process have made it a subject of intense study in both the experimental and ...
Jagesh V Shāh
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Spindle-Assembly Checkpoint and Gastrointestinal Cancer
New England Journal of Medicine, 2011To the Editor: Rio Frio et al. (Dec. 30 issue)1 report on a germline homozygous mutation in the spindle-assembly checkpoint gene BUB1B in a patient with a nonclassic form of the mosaic variegated aneuploidy syndrome, resulting in reduced expression, increased levels of constitutive aneuploidy, and multiple gastrointestinal neoplasms starting at 34 ...
de Voer, R.M. +3 more
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The spindle-assembly checkpoint in space and time
Nature Reviews Molecular Cell Biology, 2007In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint
Musacchio, Andrea, Salmon, Edward D.
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Cdh1 is an antagonist of the spindle assembly checkpoint
Cellular Signalling, 2014The spindle assembly checkpoint (SAC) monitors unsatisfied connections of microtubules to kinetochores and prevents anaphase onset by inhibition of the ubiquitin ligase E3 anaphase-promoting complex or cyclosome (APC/C) in association with the activator Cdc20.
Masayoshi, Nagai, Takashi, Ushimaru
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Slipping past the spindle assembly checkpoint
Nature Cell Biology, 2013Error-free genome segregation depends on the spindle assembly checkpoint (SAC), a signalling network that delays anaphase onset until chromosomes have established proper spindle attachments. Three reports now quantitatively examine the sensitivity and robustness of the SAC response.
Radhika, Subramanian, Tarun M, Kapoor
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Principles and dynamics of spindle assembly checkpoint signalling
Nature Reviews Molecular Cell Biology, 2023The transmission of a complete set of chromosomes to daughter cells during cell division is vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) ensures correct segregation by informing the cell cycle machinery of potential errors in the interactions of chromosomes with spindle microtubules prior to anaphase.
Andrew D. McAinsh, Geert J. P. L. Kops
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The spindle assembly checkpoint in budding yeast
1997Publisher Summary This chapter discusses the spindle assembly checkpoint in budding yeast. As cells proceed through cycles of growth and division they are often challenged by environmental insult and injury as well as spontaneous errors in cellular processes. The response to cell damage requires that cells sense the damage, arrest the cell cycle, and
A F, Straight, A W, Murray
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Sister chromatid tension and the spindle assembly checkpoint
Current Opinion in Cell Biology, 2009The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kinetochore/microtubule attachment during mitosis and halts cell cycle progression until all chromosomes are properly aligned at the metaphase plate. The state of chromosome-microtubule attachment is implicated as a crucial factor in the checkpoint response ...
Nezi, Luigi, Musacchio, Andrea
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