Results 141 to 150 of about 36,138 (257)

Centriole assembly and the role of Mps1: defensible or dispensable?

Cell Division, 2011
The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C.
Fisk Harold A, Pike Amanda N
doaj   +1 more source

Human kinetochores are swivel joints that mediate microtubule attachments

eLife, 2016
Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle – a dynamic microtubule-based force-generating machine.
Chris A Smith, Andrew D McAinsh, Nigel J Burroughs   +2 more
doaj   +1 more source

Centrosome and spindle assembly checkpoint loss leads to neural apoptosis and reduced brain size

Journal of Cell Biology, 2017
Accurate mitotic spindle assembly is critical for mitotic fidelity and organismal development. Multiple processes coordinate spindle assembly and chromosome segregation.
J. Poulton, J. Cuningham, M. Peifer
semanticscholar   +1 more source

Characterisation of the spindle assembly checkpoint in mammalian oocytes

, 2009
Vogt E-J. Characterisation of the spindle assembly checkpoint in mammalian oocytes.
Vogt, Edgar-John
core  

Regulation of Mec1 (ATR) signaling in budding yeast [PDF]

, 2014
Cells are continuously challenged by various sources of DNA damage that can contribute to cancer formation if not appropriately repaired. To cope with this threat, cells have conserved mechanisms called the DNA damage checkpoints that sense damaged DNA ...
Hustedt, Nicole
core   +1 more source

Cell size determines the strength of the spindle assembly checkpoint during embryonic development

Developmental Cell, 2016
Summary The spindle assembly checkpoint (SAC) delays mitotic progression when chromosomes are not properly attached to microtubules of the mitotic spindle. Cells vary widely in the extent to which they delay mitotic progression upon SAC activation.
M. Galli, D. Morgan
semanticscholar   +1 more source

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

Journal of Cell Biology, 2003
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as an inhibitor of chromosome alignment and segregation.
Silke Hauf, R. Cole, S. LaTerra, C. Zimmer, G. Schnapp, Rainer Walter, A. Heckel, Jacques van Meel, C. Rieder, J. Peters   +9 more
semanticscholar   +1 more source

Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase

Cell Discovery, 2017
Aurora-A kinase functions mainly in centrosome maturation, separation and spindle formation. It has also been found to be amplified or overexpressed in a range of solid tumors, which is linked with tumor progression and poor prognosis.
Fazhi Yu, Ya-Bing Jiang, Lucy Lu, Mimi Cao, Yulong Qiao, Xing Liu, Dan Liu, T. van Dyke, Fangwei Wang, X. Yao, Jing Guo, Zhenye Yang   +11 more
semanticscholar   +1 more source

Causes and consequences of maternal age-related aneuploidy in oocytes: a review

Veterinární Medicína, 2013
Although a positive correlation between aneuploidy and maternal age was first reported almost a century ago, the underlying mechanisms remain mostly unknown.
A. Danylevska, J. Sebestova
doaj   +1 more source

Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer

Journal of Ovarian Research, 2018
BackgroundOvarian cancer is the leading gynecologic cancer diagnosed in North America and because related symptoms are not disease specific, this often leads to late detection, an advanced disease state, and the need for chemotherapy.
Taryne M. Chong, A. Sarac, C. Yao, L. Liao, N. Lyttle, P. Boutros, J. Bartlett, M. Spears   +7 more
semanticscholar   +1 more source