Results 161 to 170 of about 36,138 (257)
, 2006 The treatment of malignant brain tumors poses a basic challenge in todays cancer therapy. Since the quantitative resection is hardly possible due to the invasive growth of the tumor, prevention of relapse after resection by concomitant irradiation ...
Gross, Dietmar
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, 2006 细胞有丝分裂过程中,纺锤体组装检控点监控着染色体在赤道板的队列和向纺锤体两极的分离,确保动粒-微管的黏附和有丝分裂器的完整,使所有的染色体都置于赤道板并双极定向后才进入后期,保证遗传物质均等地分配给两个子代细胞。纺锤体组装检控点缺陷将导致非整倍体的出现,并与一些肿瘤的发生密切相关。现就近年来纺锤体组装检控点蛋白以及纺锤体组装检控点功能缺陷与肿瘤的关系方面的研究进展作一简要综述。Chromosomes aligned to the metaphase plate and segregated to the
鲍仕登, 欧赛英, 欧阳高亮
core
Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target
, 2011 The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping +4 more
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Scientific ReportsThe spindle assembly checkpoint (SAC) and spindle position checkpoint (SPOC) are essential surveillance systems that ensure accurate chromosome segregation and proper spindle orientation during mitosis.
Bashar Ibrahim
doaj +1 more source
Determinants for robustness in spindle assembly checkpoint signaling
, 2013 In eukaryotes, the spindle assembly checkpoint (SAC) is crucial to ensure fidelity of chromosome segregation in mitosis. Malfunction of this checkpoint leads to chromosome segregation errors and has been implicated in tumorigenesis.
Knop, N. +9 more
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Specialisation of meiotic kinetochores revealed through a synthetic spindle assembly checkpoint strategy. [PDF]
ElifeKoch LB, Ghosh T, Spanos C, Marston AL.
europepmc +2 more sources