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Determinants of robustness in spindle assembly checkpoint signalling
Nature Cell Biology, 2013The spindle assembly checkpoint is a conserved signalling pathway that protects genome integrity. Given its central importance, this checkpoint should withstand stochastic fluctuations and environmental perturbations, but the extent of and mechanisms underlying its robustness remain unknown.
Stephanie Heinrich +9 more
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Adaptation of the spindle-assembly checkpoint
2019Antimicrotubule agents are commonly used chemotherapeutic agents that kill cancer cells by activating the spindle assembly checkpoint (SAC). However, some cancer cells can adapt to the checkpoint and exit mitosis without chromosome segregation.
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Analysis of the Spindle-Assembly Checkpoint in HeLa Cells
2004The spindle-assembly checkpoint involves signaling at kinetochores, which leads to the arrest of mitotic progression in the absence of microtubule attachment or spindle tension. Here, we detail procedures for the analysis of the spindle-assembly checkpoint in adherent mammalian cells.
Paul R, Andreassen +2 more
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Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
Nature Reviews Molecular Cell Biology, 2012Tarun Kapoor +2 more
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Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling
EMBO Journal, 2009Thomas Ruppert, Johannes Lechner
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Ablation of the spindle assembly checkpoint by a compound targeting Mps1
EMBO Reports, 2005Marc Schmidt, Rob Klompmaker
exaly
Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint
EMBO Journal, 2009Tapas Manna
exaly
Spindle assembly checkpoint and its regulators in meiosis
Human Reproduction Update, 2012Shao-Chen Sun +2 more
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