Results 151 to 160 of about 36,138 (257)

Proteome of oocyte spindle identifies Ccdc69 regulates spindle assembly like “band-tightening spell”

Cellular and Molecular Life Sciences
Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region ...
Jia-Ni Guo, Liu Zhu, Tie-Gang Meng, Yi-Na Zhang, Si-Min Sun, Xue-Mei Yang, Bing-Wang Zhao, Yi-Ke Lu, Yuan-Hong Xu, Wei Yue, Zhiming Han, Catherine C. L. Wong, Zhen-Bo Wang   +12 more
doaj   +1 more source

Spindle assembly checkpoint acquisition at the mid-blastula transition.

PLoS ONE, 2015
The spindle assembly checkpoint (SAC) maintains the fidelity of chromosome segregation during mitosis. Nonpathogenic cells lacking the SAC are typically only found in cleavage stage metazoan embryos, which do not acquire functional checkpoints until the ...
Maomao Zhang, Priyanka Kothari, Michael A Lampson   +2 more
doaj   +1 more source

Intermediate Filament Protein BFSP2 Controls Spindle Formation via HSC70‐Mediated Stabilization of CLTC During Oocyte meiosis

Advanced Science
As a major component of the cytoskeleton, intermediate filaments are generally considered to play a supporting role in mitotic cells. They also take part in the regulation of cell motility, proliferation, differentiation, and apoptosis.
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
doaj   +1 more source

A molecular analysis of the microtubule associated protein MAP65-1 [PDF]

, 2006
Microtubules (MTs) play important roles in various cellular processes including cell division, organelle movement and the determination of cellular morphology. The dynamics and organization of microtubules are regulated by microtubule associated proteins
Hsin Yu, Chang
core  

Silencing the spindle assembly checkpoint: Let’s play Polo!

, 2020
International audienceSilencing of the spindle assembly checkpoint involves two protein phosphatases, PP1 and PP2A-B56, that are thought to extinguish checkpoint signaling through dephosphorylation of a checkpoint scaffold at kinetochores. In this issue,
Piatti, Simonetta, Giorgia Benzi, Simonetta Piatti, Benzi, Giorgia   +3 more
core   +1 more source

A pivot-tether model for nucleosome recognition by the chromosomal passenger complex

EMBO Reports
Spatial restriction of Aurora B to T3-phosphorylated histone H3 (H3pT3) nucleosomes adjacent to centromeres during prometaphase and metaphase enables it to phosphorylate proteins necessary for spindle assembly checkpoint signalling and biorientation of ...
Reinis R Ruza, Chyi Wei Chung, Danny B H Gold, Michela Serena, Emile Roberts, Ulrike Gruneberg, Francis A Barr   +6 more
doaj   +1 more source

Precocious activation of APC/C-Cdh1 at pre-anaphase causes genome instability

, 2008
Faithful chromosome segregation and thereby accurate gene transmission are crucial for all organisms. Until proper attachment of the mitotic spindle to the kinetochore is established, the ubiquitin ligase (E3) Cdc20-activated APC/C (anaphase promoting ...
Takanori Ohyoshi, Masahiro Uritani, Asuka Suzuki, Ayumu Yamamoto, Masaru Ueno, Takashi Ushimaru, Kazuhiro Toda   +6 more
core  

Delayed Signaling in Mitotic Checkpoints: Biological Mechanisms and Modeling Perspectives

Biology
Time delays are intrinsic to mitotic regulation, particularly within the spindle assembly checkpoint (SAC) and the spindle position checkpoint (SPOC).
Bashar Ibrahim
doaj   +1 more source

The role of fission yeast nuclear actin-related protein in mitosis.

, 2005
Nuclear actin-related proteins (Arps) have 20-30% identity to conventional actin and many are found to be in chromatin remodelling complexes. There are two families of chromatin remodelling complexes, one of which carries out covalent modification on ...
Minoda, A., Minoda, Akiko
core  

Regulation der humanen Aurora-A Kinase und Identifikation potentieller Interaktionspartner [PDF]

, 2004
The error-free segregation of duplicated chromosomes during cell division is essential for the maintenance of an intact genome. This process is brought about by a highly dynamic bipolar array of microtubules, the mitotic spindle.
Kufer, Thomas
core