Results 121 to 130 of about 36,138 (257)
Cellular response upon proliferation in the presence of an active mitotic checkpoint
Life Science Alliance, 2019 Cells that replicate with an active mitotic checkpoint remain capable to mount multiple times an efficient arrest, are bigger than unperturbed cells, rely more heavily on Cdh1, and have an altered protein expression profile. Eukaryotic cells treated with
Andrea Corno +8 more
doaj +1 more source
Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing
eLife, 2017 Faithfull genome partitioning during cell division relies on the Spindle Assembly Checkpoint (SAC), a conserved signaling pathway that delays anaphase onset until all chromosomes are attached to spindle microtubules.
Margarida Moura +7 more
semanticscholar +1 more source
Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture
Advanced Genetics, Volume 7, Issue 2, June 2026.This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley +1 more source
An ATM and ATR dependent checkpoint inactivates spindle assembly by targeting CEP63
, 2010 The effects of ATM and ATR signalling induced by chromosomal breakage have been described extensively in modulating cell cycle progression up to the onset of mitosis.
Smith, E.A.
core
Biology Open, 2013 Summary In animal cells the centrosome is commonly viewed as the main cellular structure driving microtubule (MT) assembly into the mitotic spindle apparatus.
Nicolas Lecland +10 more
doaj +1 more source
Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension
Journal of Cell Biology, 2017 To ensure accurate chromosome segregation, the spindle assembly checkpoint (SAC) prevents anaphase until all kinetochores attach to the spindle. What signals the SAC monitors remains unclear.
Jonathan Kuhn, S. Dumont
semanticscholar +1 more source
Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis
Cellular and Molecular Life Sciences, 2022 Yuan-Jing Zou +7 more
semanticscholar +1 more source
The Spindle-Assembly Checkpoint, Aneuploidy, and Gastrointestinal Cancer [PDF]
New England Journal of Medicine, 2010 Genomic instability is a common occurrence in solid tumors, and it has long been conjectured that this process plays a causal role in cancer. The field of human molecular genetics has provided a means to test this hypothesis, fueled in part by the analysis of hereditary cancer-predisposition syndromes. Some of the first unequivocal support for the idea
openaire +2 more sources
Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
Cell Division, 2009 The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E +3 more
doaj +1 more source
MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.Schematic illustration of the development, optimization, and therapeutic evaluation of the Leucas aspera phytosome‐based thermogel for topical antipsoriatic therapy, highlighting its enhanced solubility, skin deposition, and in vivo efficacy in an imiquimod‐induced psoriasis model. Created with BioRender.com.
Ananda Kumar Chettupalli +2 more
wiley +1 more source