Results 121 to 130 of about 1,399,702 (223)
Human kinetochores are swivel joints that mediate microtubule attachments
eLife, 2016 Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle – a dynamic microtubule-based force-generating machine.
Chris A Smith +2 more
doaj +1 more source
Optimized Genome‐Wide Profiling of Centromeric Chromatin Complexes by ChIP‐seq
Current Protocols, Volume 6, Issue 10, October 2026.Abstract Centromeres are specialized chromosomal regions essential for faithful chromosome segregation and genome stability. Their highly repetitive DNA composition and epigenetically defined chromatin state present significant challenges for genome‐wide profiling approaches such as chromatin immunoprecipitation followed by sequencing (ChIP‐seq ...
Alessia Daponte +8 more
wiley +1 more source
MedComm, Volume 7, Issue 10, October 2026.Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna +3 more
wiley +1 more source
Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment
MedComm, Volume 7, Issue 10, October 2026.This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen +9 more
wiley +1 more source
The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics [PDF]
, 2015 The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression during mitosis with the state of chromosome attachment to the mitotic spindle.
Musacchio, Andrea, Musacchio, A.
core +1 more source
Causes and consequences of maternal age-related aneuploidy in oocytes: a review
Veterinární Medicína, 2013 Although a positive correlation between aneuploidy and maternal age was first reported almost a century ago, the underlying mechanisms remain mostly unknown.
A. Danylevska, J. Sebestova
doaj +1 more source
Proteome of oocyte spindle identifies Ccdc69 regulates spindle assembly like “band-tightening spell”
Cellular and Molecular Life SciencesMeiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region ...
Jia-Ni Guo +12 more
doaj +1 more source
Spindle assembly checkpoint acquisition at the mid-blastula transition.
PLoS ONE, 2015 The spindle assembly checkpoint (SAC) maintains the fidelity of chromosome segregation during mitosis. Nonpathogenic cells lacking the SAC are typically only found in cleavage stage metazoan embryos, which do not acquire functional checkpoints until the ...
Maomao Zhang +2 more
doaj +1 more source
Advanced ScienceAs a major component of the cytoskeleton, intermediate filaments are generally considered to play a supporting role in mitotic cells. They also take part in the regulation of cell motility, proliferation, differentiation, and apoptosis.
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
doaj +1 more source
A pivot-tether model for nucleosome recognition by the chromosomal passenger complex
EMBO ReportsSpatial restriction of Aurora B to T3-phosphorylated histone H3 (H3pT3) nucleosomes adjacent to centromeres during prometaphase and metaphase enables it to phosphorylate proteins necessary for spindle assembly checkpoint signalling and biorientation of ...
Reinis R Ruza +6 more
doaj +1 more source