Results 121 to 130 of about 35,751 (255)

Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex

Nature Communications
The spindle assembly checkpoint (SAC) ensures mitotic exit occurs only after sister chromatid biorientation, but how this coordination is mechanistically achieved remains unclear.
Suruchi Sethi, Sabrina Ghetti, Verena Cmentowski, Teresa Benedetta Guerriere, Patricia Stege, Valentina Piano, Andrea Musacchio   +6 more
doaj   +1 more source

Exotic mitotic mechanisms [PDF]

, 2012
The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Drechsler, Hauke, McAinsh, Andrew D.
core   +1 more source

Table S2 from Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy

, 2023
Changlong Liu, Carolyn E. Banister, Phillip Buckhaults   +2 more
openalex   +1 more source

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint [PDF]

, 2020
Yael Cohen‐Sharir, James M. McFarland, Mai Abdusamad, Carolyn Marquis, Helen Tang, Marica Rosaria Ippolito, Sara V. Bernhard, Kathrin Laue, Heidi L.H. Malaby, Andrew Jones, Mariya Kazachkova, Nicholas Lyons, Ankur K. Nagaraja, Adam J. Bass, Rameen Beroukhim, Stefano Santaguida, Jason Stumpff, Todd R. Golub, Zuzana Štorchová, Uri Ben‐David   +19 more
openalex   +1 more source

6,7-Dimethoxy-3-(3-methoxyphenyl)isoquinolin-1-amine induces mitotic arrest and apoptotic cell death through the activation of spindle assembly checkpoint in human cervical cancer cells [PDF]

, 2013
Kyung‐Sook Chung, Hye‐Eun Choi, Ji‐Sun Shin, Young‐Wuk Cho, Jung‐Hye Choi, Won‐Jea Cho, Kyung‐Tae Lee   +6 more
openalex   +1 more source

The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER+ breast cancer with mitotic aberrations

, 2022
Isabel Soria‐Bretones, Kelsie L. Thu, Jennifer Silvester, Jennifer Cruickshank, Samah El Ghamrasni, Wail Ba-Alawi, Graham C. Fletcher, Reza Kiarash, Mitchell J. Elliott, Jordan J. Chalmers, Andrea C. Elia, Albert Cheng, April A. N. Rose, Mark R. Bray, Benjamin Haibe‐Kains, Tak W. Mak, David W. Cescon   +16 more
openalex   +1 more source

The RZZ Complex and the Spindle Assembly Checkpoint

Cell Structure and Function, 2009
The conserved protein Rod is found in various organisms. It is localized on the kinetochores or spindle microtubules during cell division. Rod is required for proper chromosome segregation during both mitosis and meiosis. The effects of rod mutations are similar for both equational and reductional divisions, giving rise to anaphases with lagging ...
Yujian, Lu, Zhenyu, Wang, Liang, Ge, Ni, Chen, Heng, Liu   +4 more
openaire   +3 more sources

Condensin II is required for efficient Spindle Assembly Checkpoint activation in Drosophila male meiosis [PDF]

, 2022
Cíntia Horta, Alexandra Tavares, Raquel A. Oliveira   +2 more
openalex   +1 more source

Causes and consequences of maternal age-related aneuploidy in oocytes: a review

Veterinární Medicína, 2013
Although a positive correlation between aneuploidy and maternal age was first reported almost a century ago, the underlying mechanisms remain mostly unknown.
A. Danylevska, J. Sebestova
doaj   +1 more source

PIGN Spatiotemporally Regulates the Spindle Assembly Checkpoint Proteins in Myelodysplastic Syndromes [PDF]

, 2020
Emmanuel K. Teye, Shasha Lu, Fangyuan Chen, Wenrui Yang, Thomas Abraham, Douglas B. Stairs, Hong‐Gang Wang, Gregory S. Yochum, Robert A. Brodsky, Jeffrey J. Pu   +9 more
openalex   +1 more source