Results 91 to 100 of about 36,138 (257)
Meiotic spindle assembly checkpoint and aneuploidy in males versus females
Cellular and Molecular Life Sciences, 2018 The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister ...
Simon I. R. Lane, L. Kauppi
semanticscholar +1 more source
Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, EarlyView.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source
bir1 deletion causes malfunction of the spindle assembly checkpoint and apoptosis in yeast
Frontiers in Oncology, 2012 Cell division in yeast is a highly regulated and well studied event. Various checkpoints are placed throughout the cell cycle to ensure faithful segregation of sister chromatids.
Qun eRen +5 more
doaj +1 more source
Spindle assembly checkpoint inhibition can resensitize p53-null stem cells to cancer chemotherapy
Cancer Research, 2019 TP53 mutations are common in most human cancers, but few therapeutic options for TP53-mutant tumors exist. To identify potential therapeutic options for cancer patients with TP53 mutations, we profiled 127 FDA approved chemotherapy drugs against human ...
Changlong Liu +2 more
semanticscholar +1 more source
Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development
Cancer Science, EarlyView.Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura +3 more
wiley +1 more source
Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
Nature Communications, 2017 The spindle assembly checkpoint ensures correct chromosome segregation and relies on kinetochore localization of the Bub1 and Mad1/Mad2 checkpoint proteins.
Gang Zhang +7 more
doaj +1 more source
Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing
Cell Reports, 2019 Summary: Faithful chromosome segregation relies on the ability of the spindle assembly checkpoint (SAC) to delay anaphase onset until chromosomes are attached to the mitotic spindle via their kinetochores.
Spyridon T. Pachis +4 more
doaj +1 more source
Plant Biology, EarlyView.Cytogenetic quantification of KNL1‐labelled kinetochores in Ornithogalum kochii reveals a significant positive scaling relationship between chromosome size and kinetochore size, demonstrating that chromosome–kinetochore scaling operates even across moderate intra‐karyotype size variation.
K. Panda, M. Hroneš, F. Zedek
wiley +1 more source
Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis [PDF]
, 2010 We have studied Sds22, a conserved regulator of protein phosphatase 1 (PP1) activity, and determined its role in modulating the activity of aurora B kinase and kinetochore-microtubule inter-actions.
DeLuca, Jennifer G. +11 more
core +1 more source
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri +13 more
wiley +1 more source