Results 71 to 80 of about 17,939 (176)
Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 468-484, September 2026.ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri +13 more
wiley +1 more source
Cellular response upon proliferation in the presence of an active mitotic checkpoint
Life Science Alliance, 2019 Cells that replicate with an active mitotic checkpoint remain capable to mount multiple times an efficient arrest, are bigger than unperturbed cells, rely more heavily on Cdh1, and have an altered protein expression profile. Eukaryotic cells treated with
Andrea Corno +8 more
doaj +1 more source
Hypoxia Induces a Mitotic Survival Advantage After Radiotherapy in Head and Neck Cancer Cells
International Journal of Cancer, Volume 159, Issue 4, Page 1042-1055, 15 August 2026.Hypoxic tumor environments significantly limit radiotherapy effectiveness against cancer, particularly in head and neck squamous cell carcinoma (HNSCC). Here, the authors tracked hypoxic and post‐hypoxic cells using a hypoxia‐fate mapping system in human papillomavirus (HPV)‐positive and HPV‐negative HNSCC models.
Marilyn Wegge +3 more
wiley +1 more source
Nature Communications, 2019 During the spindle assembly checkpoint, the activity of the anaphase promoting complex/cyclosome (APC/C) is repressed, yet cyclin A2 evades the checkpoint and is targeted for degradation.
Suyang Zhang +2 more
doaj +1 more source
Biology Open, 2013 Summary In animal cells the centrosome is commonly viewed as the main cellular structure driving microtubule (MT) assembly into the mitotic spindle apparatus.
Nicolas Lecland +10 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu +7 more
wiley +1 more source
The Spindle-Assembly Checkpoint, Aneuploidy, and Gastrointestinal Cancer [PDF]
New England Journal of Medicine, 2010 Genomic instability is a common occurrence in solid tumors, and it has long been conjectured that this process plays a causal role in cancer. The field of human molecular genetics has provided a means to test this hypothesis, fueled in part by the analysis of hereditary cancer-predisposition syndromes. Some of the first unequivocal support for the idea
openaire +2 more sources
Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, Volume 269, Issue 4-5, Page 387-398, August 2026.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source
A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling
eLife, 2017 The master spindle checkpoint kinase Mps1 senses kinetochore-microtubule attachment and promotes checkpoint signaling to ensure accurate chromosome segregation.
Zhejian Ji +4 more
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Plant Biology, Volume 28, Issue 5, Page 1737-1742, August 2026.Cytogenetic quantification of KNL1‐labelled kinetochores in Ornithogalum kochii reveals a significant positive scaling relationship between chromosome size and kinetochore size, demonstrating that chromosome–kinetochore scaling operates even across moderate intra‐karyotype size variation.
K. Panda, M. Hroneš, F. Zedek
wiley +1 more source