Results 71 to 80 of about 36,138 (257)

Human TPX2 is required for targeting Aurora-A kinase to the spindle [PDF]

, 2002
Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human Aurora-A binds to TPX2, a prominent component of the spindle apparatus.
Roman Körner, Erich A. Nigg, Oliver J. Gruss, Silljé, Herman H. W., Gruss, O. J., Kufer, T. A., Körner, R., Nigg, E. A., Meraldi, P., Sillje, H. H. W., Thomas A. Kufer, Kufer, Thomas A., Gruss, Oliver J., Nigg, Erich A., Koerner, R., Patrick Meraldi, Körner, Roman, Meraldi, Patrick, Herman H.W. Silljé   +18 more
core   +1 more source

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]

, 2014
The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
David A Robinson, Robinson, David A., Corbishley, Stephen, Stark, Michael J. R., Vasso Makrantoni, Michael J R Stark, Makrantoni Vasso, Najma Rachidi, Morrice Nicholas A., Robinson David A., Corbishley Stephen J., Makrantoni, Vasso, Stephen J Corbishley, Stark Michael J. R., Nicholas A Morrice, Rachidi, Najma, Morrice, Nicholas A., Rachidi Najma   +17 more
core   +1 more source

Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay

Nature Communications, 2017
The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity ...
Menuka Karki, Neda Keyhaninejad, Charles B. Shuster   +2 more
doaj   +1 more source

The maize Divergent spindle-1 (dv1) gene encodes a kinesin-14A motor protein required for meiotic spindle pole organization

Frontiers in Plant Science, 2016
The classic maize mutant divergent spindle-1 (dv1) causes failures in meiotic spindle assembly and a decrease in pollen viability. By analyzing two independent dv1 alleles we demonstrate that this phenotype is caused by mutations in a member of the ...
David M Higgins, Natalie J Nannas, R Kelly Dawe, R Kelly Dawe   +3 more
doaj   +1 more source

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A [PDF]

, 2013
Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation
Erich A. Nigg, Francis A. Barr, Baron, Ryan D., Ricardo Nunes Bastos, Nunes Bastos, R, Ryan D. Baron, Nigg, EA, Gruneberg, Ulrike, Gandhi, Sapan R., Baron, RD, Barr, Francis, Gandhi, SR, Nunes Bastos, Ricardo, Ulrike Gruneberg, Nigg, Erich A., Sapan R. Gandhi, Barr, Francis A.   +16 more
core   +1 more source

Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase

Cell Reports, 2016
Summary: The spindle assembly checkpoint (SAC) monitors chromosome attachment defects, and the assembly of SAC proteins at kinetochores is essential for its activation, but the SAC disassembly process remains unknown.
Michael Bokros, Curtis Gravenmier, Fengzhi Jin, Daniel Richmond, Yanchang Wang   +4 more
doaj   +1 more source

Regulation of chromosome congression : focus on the function of hSpindly and the kinetochore recruitment of the Ska complex [PDF]

, 2011
Mitosis is a process in which cells divide their genetic materials equally into two daughter cells. During mitosis, specialized structures called kinetochores (KTs), located at the centromeric regions of chromosomes, are captured by microtubules (MTs ...
Chan, Ying Wai
core   +1 more source

Melatonin Improves In Vitro Development of Vitrified-Warmed Mouse Germinal Vesicle Oocytes Potentially via Modulation of Spindle Assembly Checkpoint-Related Genes

Cells, 2019
The present study aimed to investigate the effect of melatonin (MT) supplementation on in vitro maturation of vitrified mouse germinal vesicle (GV) oocytes.
Z. Wu, Bo Pan, I. H. Qazi, Haoxuan Yang, Shichao Guo, Jingyu Yang, Yan Zhang, C. Zeng, Ming Zhang, Hongbing Han, Q. Meng, Guangbin Zhou   +11 more
semanticscholar   +1 more source

Borealin : a novel chromosomal passenger required for stability of the bipolar mitotic spindle [PDF]

, 2004
The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex.
Erich A. Nigg, Ana Carvalho, Dietlind L. Gerloff, Reto Gassmann, Sandrine Ruchaud, Nigg, E. A., Henzing, Alexander J., Nigg, Erich A., Hudson, D. E., Damien F. Hudson, Reiko Honda, Honda, Reiko, Gassmann, Reto, Gassmann, R., Ruchaud, Sandrine, Earnshaw, William C., Hudson, Damien F., Carvalho, Ana, Ruchaud, S., Honda, R., Gerloff, D. L., Earnshaw, W. C., Alexander J. Henzing, William C. Earnshaw, Henzing, A. J., Carvalho, A., Gerloff, Dietlind L.   +26 more
core   +1 more source

Mapping Mitotic Death: Functional Integration of Mitochondria, Spindle Assembly Checkpoint and Apoptosis

Front. Cell Dev. Biol., 2019
Targeting the mitotic pathways of rapidly proliferating tumor cells has been an effective strategy in traditional cancer therapy. Chemotherapeutics such as taxanes and vinca alkaloids, which disrupt microtubule function, have enjoyed clinical success ...
Weimei Ruan, Hong-Hwa Lim, U. Surana
semanticscholar   +1 more source