Results 71 to 80 of about 1,399,702 (223)

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

bir1 deletion causes malfunction of the spindle assembly checkpoint and apoptosis in yeast

Frontiers in Oncology, 2012
Cell division in yeast is a highly regulated and well studied event. Various checkpoints are placed throughout the cell cycle to ensure faithful segregation of sister chromatids.
Qun eRen, Liang-Chun eLiou, Qiuqiang eGao, Qiuqiang eGao, Xiaoming eBao, Zhaojie eZhang   +5 more
doaj   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Stochastic modelling of chromosomal segregation : errors can introduce correction [PDF]

, 2014
Cell division is a complex process requiring the cell to have many internal checks so that division may proceed and be completed correctly. Failure to divide correctly can have serious consequences, including progression to cancer.
Roitershtein, Alexander, Matzavinos, Anastasios, Voller, Zachary, Liu, Sijia, Shtylla, Blerta, Chaplain, Mark A.J.   +5 more
core   +1 more source

Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

Nature Communications, 2017
The spindle assembly checkpoint ensures correct chromosome segregation and relies on kinetochore localization of the Bub1 and Mad1/Mad2 checkpoint proteins.
Gang Zhang, Thomas Kruse, Blanca López-Méndez, Kathrine Beck Sylvestersen, Dimitriya H. Garvanska, Simone Schopper, Michael Lund Nielsen, Jakob Nilsson   +7 more
doaj   +1 more source

Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing

Cell Reports, 2019
Summary: Faithful chromosome segregation relies on the ability of the spindle assembly checkpoint (SAC) to delay anaphase onset until chromosomes are attached to the mitotic spindle via their kinetochores.
Spyridon T. Pachis, Yoshitaka Hiruma, Eelco C. Tromer, Anastassis Perrakis, Geert J.P.L. Kops   +4 more
doaj   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Characterisation of the spindle assembly checkpoint in mammalian oocytes [PDF]

, 2009
Vogt E-J. Characterisation of the spindle assembly checkpoint in mammalian oocytes.
Vogt, Edgar-John
core  

Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly [PDF]

, 2009
In animal somatic cells, bipolar spindle formation requires separation of the centrosome-based spindle poles. Centrosome separation relies on multiple pathways, including cortical forces and antiparallel microtubule (MT) sliding, which are two activities
Winter, Jennifer R., Toso, Alberto, Ainslie J. Garrod, Garrod, Ainslie J., Alberto Toso, Jennifer R. Winter, Ana C. Amaro, Patrick Meraldi, Amaro, Ana C., McAinsh, Andrew D., Meraldi, Patrick, Andrew D. McAinsh   +11 more
core   +1 more source

The current view for the silencing of the spindle assembly checkpoint [PDF]

Cell Cycle, 2014
Chromosome bipolar attachment is achieved when sister kinetochores are attached by microtubules emanating from opposite spindle poles, and this process is essential for faithful chromosome segregation during anaphase. A fundamental question in cell biology is how cells ensure that chromosome segregation only occurs after bipolar attachment.
Yanchang, Wang, Fengzhi, Jin, Ryan, Higgins, Kelly, McKnight   +3 more
openaire   +2 more sources