Results 51 to 60 of about 327,045 (196)

Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay

Nature Communications, 2017
The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity ...
Menuka Karki, Neda Keyhaninejad, Charles B. Shuster   +2 more
doaj   +1 more source

Ca2+ Release by IP3 Receptors Is Required to Orient the Mitotic Spindle

Cell Reports, 2020
Summary: The mitotic spindle distributes chromosomes evenly to daughter cells during mitosis. The orientation of the spindle, guided by internal and external cues, determines the axis of cell division and thereby contributes to tissue morphogenesis ...
Raul Lagos-Cabré, Adelina Ivanova, Colin W. Taylor   +2 more
doaj   +1 more source

Mitotic chromosomes scale to nuclear-cytoplasmic ratio and cell size in Xenopus

eLife, 2023
During the rapid and reductive cleavage divisions of early embryogenesis, subcellular structures such as the nucleus and mitotic spindle scale to decreasing cell size.
Coral Y Zhou, Bastiaan Dekker, Ziyuan Liu, Hilda Cabrera, Joel Ryan, Job Dekker, Rebecca Heald   +6 more
doaj   +1 more source

Scaling, Selection, and Evolutionary Dynamics of the Mitotic Spindle

Current Biology, 2015
Summary Background: Cellular structures such as the nucleus, Golgi, centrioles, and spindle show remarkable diversity between species, but the mechanisms that produce these variations in cell biology are not known.
R. Farhadifar, C. Baer, Aurore-Cécile Valfort, Erik C. Andersen, T. Müller-Reichert, M. Delattre, D. Needleman   +6 more
semanticscholar   +1 more source

Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells

Molecular Cancer, 2013
Background During metaphase clathrin stabilises the mitotic spindle kinetochore(K)-fibres. Many anti-mitotic compounds target microtubule dynamics.
Smith Charlotte M, Haucke Volker, McCluskey Adam, Robinson Phillip J, Chircop Megan   +4 more
doaj   +1 more source

NudC deacetylation regulates mitotic progression.

PLoS ONE, 2013
Mitosis is largely driven by posttranslational modifications of proteins. Recent studies suggest that protein acetylation is prevalent in mitosis, but how protein acetylation/deacetylation regulates mitotic progression remains unclear.
Carol Chuang, Jing Pan, David H Hawke, Sue-Hwa Lin, Li-yuan Yu-Lee   +4 more
doaj   +1 more source

Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1.

PLoS ONE, 2010
Microtubule-targeting drugs induce mitotic delay at pro-metaphase by preventing the spindle assembly checkpoint to be satisfied. However, especially after prolonged treatments, cells can escape this arrest in a process called mitotic slippage.
Ana Lúcia Mena, Eric W-F Lam, Sukalyan Chatterjee   +2 more
doaj   +1 more source

Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

eLife
The spindle assembly checkpoint (SAC) temporally regulates mitosis by preventing progression from metaphase to anaphase until all chromosomes are correctly attached to the mitotic spindle.
KC Farrell, Jennifer T Wang, Tim Stearns
doaj   +1 more source

Transient defects of mitotic spindle geometry and chromosome segregation errors

Cell Division, 2012
Assembly of a bipolar mitotic spindle is essential to ensure accurate chromosome segregation and prevent aneuploidy, and severe mitotic spindle defects are typically associated with cell death. Recent studies have shown that mitotic spindles with initial
Silkworth William T, Cimini Daniela
doaj   +1 more source

Rab11-endosomes contribute to mitotic spindle orientation

Developmental Cell, 2014
During interphase, Rab11-GTPase-containing endosomes recycle endocytic cargo. However, little is known about Rab11 and endosomes in mitosis. Here we show that Rab11 localizes to the mitotic spindle and regulates dynein-dependent endosome localization at ...
Heidi Hehnly, S. Doxsey
semanticscholar   +1 more source