Results 71 to 80 of about 205,638 (297)
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
NudC deacetylation regulates mitotic progression.
PLoS ONE, 2013 Mitosis is largely driven by posttranslational modifications of proteins. Recent studies suggest that protein acetylation is prevalent in mitosis, but how protein acetylation/deacetylation regulates mitotic progression remains unclear.
Carol Chuang +4 more
doaj +1 more source
Transient defects of mitotic spindle geometry and chromosome segregation errors
Cell Division, 2012 Assembly of a bipolar mitotic spindle is essential to ensure accurate chromosome segregation and prevent aneuploidy, and severe mitotic spindle defects are typically associated with cell death. Recent studies have shown that mitotic spindles with initial
Silkworth William T, Cimini Daniela
doaj +1 more source
Investigation into how mitotic spindle checkpoint function is compromised by Sv40 large T antigen. [PDF]
, 2005 The viral oncoprotein Simian virus 40 large T antigen (LT) efficiently immortalises primary rodent cells and occasionally transforms them to tumourigenicity.
Lock, Rowena Lesley, Lock, R.L.
core
Characterization of mitotic checkpoint complexes [PDF]
, 2011 In eukaryotes, chromosome segregation critically depends on the establishment of productive contacts between kinetochores (KTs), specialized chromosomal structures, and the spindle microtubules (MTs).
Fava, Luca
core +1 more source
Advanced Science, EarlyView.Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang +9 more
wiley +1 more source
eLifeThe spindle assembly checkpoint (SAC) temporally regulates mitosis by preventing progression from metaphase to anaphase until all chromosomes are correctly attached to the mitotic spindle.
KC Farrell, Jennifer T Wang, Tim Stearns
doaj +1 more source
Cell Polarity and Morphogenesis: Functions and Mechanisms of Cell Divisions in Vertebrate Gastrulation [PDF]
, 2004 Gastrulation shapes a vertebrate embryo from an egg-shaped aggregate of cells. In many vertebrates, massive cell divisions occur during gastrulation. In this thesis, I investigate the pattern, function, and regulation of mitotic divisions in zebrafish ...
Gong, Ying, Ying Gong
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Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Differing requirements for Augmin in male meiotic and mitotic spindle formation in Drosophila [PDF]
Open Biology, 2014 Animal cells divide using a microtubule-based, bipolar spindle. Both somatic, mitotic cells and sperm-producing male meiotic spermatocytes use centrosome-dependent and acentrosomal spindle-forming mechanisms.
Matthew S. Savoian, David M. Glover
doaj +1 more source