Results 71 to 80 of about 327,045 (196)
Mechanical design principles of a mitotic spindle
eLife, 2014 An organised spindle is crucial to the fidelity of chromosome segregation, but the relationship between spindle structure and function is not well understood in any cell type.
J. J. Ward +3 more
semanticscholar +1 more source
Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex
Nature Communications, 2013 The human neocortex is increased in size and complexity as compared with most other species. Neocortical expansion has recently been attributed to protracted neurogenesis by outer radial glial cells in the outer subventricular zone, a region present in ...
Bridget E LaMonica +3 more
semanticscholar +1 more source
Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.
PLoS ONE, 2014 The regulation of chromosome separation during mitosis is not fully understood yet. Microtubules forming mitotic spindles are targets of treatment strategies which are aimed at (i) the triggering of the apoptosis or (ii) the interruption of uncontrolled ...
Daniel Havelka +3 more
doaj +1 more source
Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle
Open Biology, 2013 The correct assembly and timely disassembly of the mitotic spindle is crucial for the propagation of the genome during cell division. Aurora kinases play a central role in orchestrating bipolar spindle establishment, chromosome alignment and segregation.
H. Hochegger +2 more
semanticscholar +1 more source
Mitotic spindle scaling during Xenopus development by kif2a and importin α
eLife, 2013 Early development of many animals is characterized by rapid cleavages that dramatically decrease cell size, but how the mitotic spindle adapts to changing cell dimensions is not understood.
J. Wilbur, R. Heald
semanticscholar +1 more source
Scientific Reports, 2018 Precise mitotic spindle orientation is essential for both cell fate and tissue organization while defects in this process are associated with tumorigenesis and other diseases.
Barbara Vodicska +3 more
doaj +1 more source
eLife, 2016 The spindle position checkpoint (SPOC) is a spindle pole body (SPB, equivalent of mammalian centrosome) associated surveillance mechanism that halts mitotic exit upon spindle mis-orientation.
Yuliya Gryaznova +4 more
doaj +1 more source
Phosphorylation of Crm1 by CDK1–cyclin-B promotes Ran-dependent mitotic spindle assembly
Journal of Cell Science, 2013 Summary Mitotic spindle assembly in animal cells is orchestrated by a chromosome-dependent pathway that directs microtubule stabilization. RanGTP generated at chromosomes releases spindle assembly factors from inhibitory complexes with importins, the ...
Zhige Wu +3 more
semanticscholar +1 more source
Cell Reports, 2013 Cell fate determination in the progeny of mammary epithelial stem/progenitor cells remains poorly understood. Here, we have examined the role of the mitotic kinase Aurora A (AURKA) in regulating the balance between basal and luminal mammary lineages.
Joseph L. Regan +9 more
semanticscholar +1 more source
Cell Division, 2008 During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essential prerequisite for the equal segregation of chromosomes. The spindle assembly checkpoint can prevent chromosome segregation as long as not all chromosome pairs ...
Maia André F +2 more
doaj +1 more source