Results 81 to 90 of about 327,045 (196)
New Roles of Chk1 in Spindle Formation and Genome Integrity
BiologyDuring mitosis sister chromatids are accurately segregated into two daughter cells through a microtubule-based structure known as the mitotic spindle. Errors in mitotic spindle formation have been associated with human diseases and tumorigenesis.
Sofia Balafouti +2 more
doaj +1 more source
EMBO Molecular Medicine, 2016 The mitotic spindle assembly checkpoint (SAC) maintains genome stability and marks an important target for antineoplastic therapies. However, it has remained unclear how cells execute cell fate decisions under conditions of SAC‐induced mitotic arrest ...
Katharina Engel +22 more
doaj +1 more source
Radmis, a Novel Mitotic Spindle Protein that Functions in Cell Division of Neural Progenitors
PLoS ONE, 2013 Developmental dynamics of neural stem/progenitor cells (NSPCs) are crucial for embryonic and adult neurogenesis, but its regulatory factors are not fully understood.
Takahito Yumoto +6 more
semanticscholar +1 more source
Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint
Cells, 2015 The segregation of the chromosomes during mitosis is an important process, in which the replicated DNA content is properly allocated into two daughter cells.
Ikram Mossaid, Birthe Fahrenkrog
doaj +1 more source
Mitotic rounding alters cell geometry to ensure efficient bipolar spindle formation.
Developmental Cell, 2013 Accurate animal cell division requires precise coordination of changes in the structure of the microtubule-based spindle and the actin-based cell cortex.
Oscar M. Lancaster +8 more
semanticscholar +1 more source
Haematologica, 2013 Spindle poison-based therapy is of only limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds well. In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast ...
Dominik Schnerch +7 more
doaj +1 more source
The effect of magnesium on mitotic spindle formation in Schizosaccharomyces pombe
Genetics and Molecular BiologyMagnesium (Mg2+), an essential ion for cells and biological systems, is involved in a variety of cellular processes, including the formation and breakdown of microtubules.
Gulsen Uz, Aysegul Topal Sarikaya
doaj +1 more source
Contractile perinuclear actomyosin network promotes peripheral and polar chromosome interaction with the mitotic spindle. [PDF]
ElifeSheidaei N +5 more
europepmc +2 more sources