Results 61 to 70 of about 130,672 (286)

Mitotic spindle scaling during Xenopus development by kif2a and importin α. [PDF]

, 2012
Early development of many animals is characterized by rapid cleavages that dramatically decrease cell size, but how the mitotic spindle adapts to changing cell dimensions is not understood.
HEALD, Rebecca, Wilbur, Jeremy
core   +2 more sources

Controllable Dynamic Mechanical Cell Stimulation using Magnetically Actuated Artificial Cilia

Advanced Healthcare Materials, EarlyView.
This paper introduces a platform based on magnetic artificial cilia for providing controllable dynamic mechanical stimulation to single cells, suitable for investigating large cell populations and enabling live cell imaging. Proof‐of‐principle experiments show that cell morphology is strongly influenced by the artificial cilia, that cellular forces can
Roel Kooi, Tanveer Ul Islam, Oscar M.J.A. Stassen, Naomie Amsing, Jan de Boer, Jaap M.J. den Toonder   +5 more
wiley   +1 more source

Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells

Molecular Cancer, 2013
Background During metaphase clathrin stabilises the mitotic spindle kinetochore(K)-fibres. Many anti-mitotic compounds target microtubule dynamics.
Smith Charlotte M, Haucke Volker, McCluskey Adam, Robinson Phillip J, Chircop Megan   +4 more
doaj   +1 more source

The distribution of cytoplasmic microtubules throughout the cell cycle of the centric diatom Stephanopyxis turris: their role in nuclear migration and positioning the mitotic spindle during cytokinesis. [PDF]

, 1986
The cell cycle of the marine centric diatom Stephanopyxis turris consists of a series of spatially and temporally well-ordered events. We have used immunofluorescence microscopy to examine the role of cytoplasmic microtubules in these events.
Cande, WZ, McDonald, KL, Wordeman, L
core  

The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation [PDF]

, 2015
The formation of the mitotic spindle is a complex process that requires massive cellular reorganization. Regulation by mitotic kinases controls this entire process. One of these mitotic controllers is Aurora A kinase, which is itself highly regulated. In
Achim Temme, Allan C, Angela Huebner, Arnaoutov A., Asteriti IA, Asteriti IA, Babu JR, Bakhoum SF, Bayliss R, Belgareh N, Bird AW, Blower MD, Boisvert FM, Bowman SK, Chatel G, Cheeseman LP, Chen H, Ciciarello M, Compton DA, Conduit PT, Cronshaw JM, Cronshaw JM, Dodson CA, Dodson CA, Eric R. Griffis, Eyers PA, Eyers PA, Goodman B, Goodwin SS, Goshima G, Griffis ER, Handschug K, Hirano M, Hirota T, Hochegger H, Huebner A, Hutterer A, Itoh G, Jang CY, Jeganathan KB, Joseph J, Joukov V, Joukov V, Joukov V, Kalab P, Katrin Koehler, Kettenbach AN, Kind B, Kind B, King JM, Kiriyama T, Krumbholz M, Lee SH, Lince-Faria M, Lioutas A, Littlepage LE, Merdes A, Merdes A, Meunier S, Miguel Arocena, Mishra RK, Olsen JV, Otsu N, Pinyol R, Poser I, Prasad R, Reboutier D, Rogers SL, Rome P, Samora CP, Sara Carvalhal, Sardon T, Satinover DL, Schweizer N, Sdelci S, Silk AD, Sillje HH, Storr HL, Susana Abreu Ribeiro, Taciana Kasciukovic, Toughiri R, Tsai CY, Tsai MY, Tsai MY, Wang LH, Yixian Zheng, Zeng K, Zhao ZS, Zheng Y, Zorba A   +89 more
core   +3 more sources

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

NudC deacetylation regulates mitotic progression.

PLoS ONE, 2013
Mitosis is largely driven by posttranslational modifications of proteins. Recent studies suggest that protein acetylation is prevalent in mitosis, but how protein acetylation/deacetylation regulates mitotic progression remains unclear.
Carol Chuang, Jing Pan, David H Hawke, Sue-Hwa Lin, Li-yuan Yu-Lee   +4 more
doaj   +1 more source

Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1.

PLoS ONE, 2010
Microtubule-targeting drugs induce mitotic delay at pro-metaphase by preventing the spindle assembly checkpoint to be satisfied. However, especially after prolonged treatments, cells can escape this arrest in a process called mitotic slippage.
Ana Lúcia Mena, Eric W-F Lam, Sukalyan Chatterjee   +2 more
doaj   +1 more source

Co-silencing of human Bub3 and dynein highlights an antagonistic relationship in regulating kinetochore-microtubule attachments [PDF]

, 2015
We previously reported that the spindle assembly checkpoint protein Bub3 is involved in regulating kinetochore-microtubule (KT-MT) attachments. Also, Bub3 was reported to interact with the microtubule motor protein dynein.
Barisic, Efimov, Gassmann, Gassmann, Gassmann, Hassan Bousbaa, Kops, Lo, Logarinho, Logarinho, Maia, Maresca, Musacchio, Patrícia M.A. Silva, Pfarr, Reis, Rieder, Sharp, Silva, Silva, Stehman, Steuer, Uchida, Vaisberg, Varma, Waters, Yang, Álvaro A. Tavares   +27 more
core   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source