Results 61 to 70 of about 327,045 (196)
Differing requirements for Augmin in male meiotic and mitotic spindle formation in Drosophila [PDF]
Open Biology, 2014 Animal cells divide using a microtubule-based, bipolar spindle. Both somatic, mitotic cells and sperm-producing male meiotic spermatocytes use centrosome-dependent and acentrosomal spindle-forming mechanisms.
Matthew S. Savoian, David M. Glover
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The mitotic spindle and actin tails [PDF]
Biology of the Cell, 2004 Summry— To segregate their chromosomes, eukaryotic cells rely on a dynamic structure made of microtubules: the mitotic spindle. This structure can form in cells lacking centrosomes, because their chromosomes also nucleate microtubules. This second assembly pathway is observed even in some cells that naturally have centrosomes, for example when the ...
Eric, Karsenti, François, Nédélec
openaire +2 more sources
Endosulfine alpha maintains spindle pole integrity by recruiting Aurora A during mitosis
BMC Cancer, 2023 Background The maintenance of spindle pole integrity is essential for spindle assembly and chromosome segregation during mitosis. However, the underlying mechanisms governing spindle pole integrity remain unclear.
Seul Kim +5 more
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Effect of Cell Shape and Dimensionality on Spindle Orientation and Mitotic Timing. [PDF]
PLoS ONE, 2013 The formation and orientation of the mitotic spindle is a critical feature of mitosis. The morphology of the cell and the spatial distribution and composition of the cells' adhesive microenvironment all contribute to dictate the position of the spindle ...
Mirren Charnley +4 more
doaj +1 more source
Developmental Cell, 2014 Summary The mitotic spindle is defined by its organized, bipolar mass of microtubules, which drive chromosome alignment and segregation. Although different cells have been shown to use different molecular pathways to generate the microtubules required ...
D. Hayward +3 more
semanticscholar +1 more source
A Protein Interaction Map of the Mitotic Spindle [PDF]
Molecular Biology of the Cell, 2007 The mitotic spindle consists of a complex network of proteins that segregates chromosomes in eukaryotes. To strengthen our understanding of the molecular composition, organization, and regulation of the mitotic spindle, we performed a system-wide two-hybrid screen on 94 proteins implicated in spindle function in Saccharomyces cerevisiae. We report 604
Wong, Jonathan +11 more
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Mitotic Membrane Helps to Focus and Stabilize the Mitotic Spindle [PDF]
Biophysical Journal, 2010 During mitosis, microtubules (MTs), aided by motors and associated proteins, assemble into a mitotic spindle. Recent evidence supports the notion that a membranous spindle matrix aids spindle formation; however, the mechanisms by which the matrix may contribute to spindle assembly are unknown.
Poirier, Christopher C. +2 more
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Force and the spindle: Mechanical cues in mitotic spindle orientation
Seminars in Cell and Developmental Biology, 2014 The mechanical environment of a cell has a profound effect on its behaviour, from dictating cell shape to driving the transcription of specific genes.
Alexander Nestor-Bergmann +2 more
semanticscholar +1 more source
Proteome Analysis of the Human Mitotic Spindle [PDF]
Molecular & Cellular Proteomics, 2005 The accurate distribution of sister chromatids during cell division is crucial for the generation of two cells with the same complement of genetic information. A highly dynamic microtubule-based structure, the mitotic spindle, carries out the physical separation of the chromosomes to opposite poles of the cells and, moreover, determines the cell ...
Sauer, Guido +5 more
openaire +3 more sources
Adducin-1 is essential for mitotic spindle assembly through its interaction with myosin-X
Journal of Cell Biology, 2014 The actin-binding protein ADD1 associates with mitotic spindles through Myo10 and is crucial for proper spindle assembly and mitotic progression.
P. Chan +4 more
semanticscholar +1 more source