Results 41 to 50 of about 205,638 (297)
USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. [PDF]
PLoS ONE, 2018 Correct segregation of the mitotic chromosomes into daughter cells is a highly regulated process critical to safeguard genome stability. During M phase the spindle assembly checkpoint (SAC) ensures that all kinetochores are correctly attached before its ...
Anna Stockum +2 more
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Length-dependent anisotropic scaling of spindle shape [PDF]
, 2014 Spindle length varies dramatically across species and during early development to segregate chromosomes optimally. Both intrinsic factors, such as regulatory molecules, and extrinsic factors, such as cytoplasmic volume, determine spindle length scaling ...
Sébastien Besson +5 more
core +1 more source
Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression
Scientific Reports, 2017 EG5 (KIF11) is a member of the kinesin-like protein family involved in centrosome separation and bipolar spindle formation. When a cell enters mitosis, CDK1 phosphorylates EG5 at Thr926 and promotes EG5 localization on the mitotic spindle which drives ...
Yang Liu +9 more
doaj +1 more source
Asymmetry of the budding yeast Tem1 GTPase at spindle poles is required for spindle positioning but not for mitotic exit. [PDF]
PLoS Genetics, 2015 The asymmetrically dividing yeast S. cerevisiae assembles a bipolar spindle well after establishing the future site of cell division (i.e., the bud neck) and the division axis (i.e., the mother-bud axis).
Ilaria Scarfone +5 more
doaj +1 more source
Force and Length in the Mitotic Spindle [PDF]
Current Biology, 2009 The mitotic spindle assembles to a steady-state length at metaphase through the integrated action of molecular mechanisms that generate and respond to mechanical forces. While molecular mechanisms that produce force have been described, our understanding of how they integrate with each other, and with the assembly/disassembly mechanisms that regulate ...
Dumont, Sophie, Mitchison, Timothy J.
openaire +2 more sources
Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint [PDF]
, 2007 Mitotic progression is controlled by proteolytic destruction of securin and cyclin. The mitotic E3 ubiquitin ligase, known as the anaphase promoting complex or cyclosome (APC/C), in partnership with its activators Cdc20p and Cdh1p, targets these proteins
Emma M J King +8 more
core +2 more sources
Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B
Cell Reports, 2023 Summary: Matrin3 is an RNA-binding protein that regulates diverse RNA-related processes, including mRNA splicing. Although Matrin3 has been intensively studied in neurodegenerative diseases, its function in cancer remains unclear. Here, we report Matrin3-
Bruna R. Muys +13 more
doaj +1 more source
Mitotic Spindle Form and Function [PDF]
Genetics, 2012 Abstract The Saccharomyces cerevisiae mitotic spindle in budding yeast is exemplified by its simplicity and elegance. Microtubules are nucleated from a crystalline array of proteins organized in the nuclear envelope, known as the spindle pole body in yeast (analogous to the centrosome in larger eukaryotes). The spindle has two classes of
Mark, Winey, Kerry, Bloom
openaire +2 more sources
Cell ReportsSummary: Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of mitotic progression, yet few have been shown to act directly at the mitotic spindle.
Sagar Mahale +8 more
doaj +1 more source
eLife, 2015 Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors.
Heidi Hehnly +8 more
doaj +1 more source