Results 41 to 50 of about 327,045 (196)
eLife, 2015 Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors.
Heidi Hehnly +8 more
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Cep192 and the generation of the mitotic spindle [PDF]
Cell Cycle, 2008 The cellular mechanisms used to generate sufficient microtubule polymer mass to drive the assembly and function of the mitotic spindle remain a matter of great interest. As the primary microtubule nucleating structures in somatic animal cells, centrosomes have been assumed to figure prominently in spindle assembly.
Maria Ana, Gomez-Ferreria +1 more
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Expansion microscopy of the mitotic spindle [PDF]
, 2021 The mitotic spindle is a dynamic and complex cellular structure made of microtubules and associated proteins. Although the general localization of most proteins has been identified, the arrangement of the microtubules in the mitotic spindle and precise localization of various proteins are still under intensive research.
Ponjavić, Ivana +2 more
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FGFR3–TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle [PDF]
Open Biology, 2017 Fibroblast growth factor receptor 3–transforming acidic coiled-coil containing protein 3 (FGFR3–TACC3; FT3) is a gene fusion resulting from rearrangement of chromosome 4 that has been identified in many cancers including those of the urinary bladder ...
Sourav Sarkar +2 more
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Self-Organization and Forces in the Mitotic Spindle.
Annual Review of Biophysics, 2016 At the onset of division, the cell forms a spindle, a precise self-constructed micromachine composed of microtubules and the associated proteins, which divides the chromosomes between the two nascent daughter cells.
N. Pavin, I. Tolic
semanticscholar +1 more source
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition
Nature, 2021 Selective targeting of aneuploid cells is an attractive strategy for cancer treatment1. However, it is unclear whether aneuploidy generates any clinically relevant vulnerabilities in cancer cells.
Yael Cohen-Sharir +25 more
semanticscholar +1 more source
Force and Length in the Mitotic Spindle [PDF]
Current Biology, 2009 The mitotic spindle assembles to a steady-state length at metaphase through the integrated action of molecular mechanisms that generate and respond to mechanical forces. While molecular mechanisms that produce force have been described, our understanding of how they integrate with each other, and with the assembly/disassembly mechanisms that regulate ...
Dumont, Sophie, Mitchison, Timothy J.
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Scientific Reports, 2015 Tumor Treating Fields (TTFields) are low intensity, intermediate frequency, alternating electric fields. TTFields are a unique anti-mitotic treatment modality delivered in a continuous, noninvasive manner to the region of a tumor.
M. Giladi +15 more
semanticscholar +1 more source
Mitotic Spindle Form and Function [PDF]
Genetics, 2012 Abstract The Saccharomyces cerevisiae mitotic spindle in budding yeast is exemplified by its simplicity and elegance. Microtubules are nucleated from a crystalline array of proteins organized in the nuclear envelope, known as the spindle pole body in yeast (analogous to the centrosome in larger eukaryotes). The spindle has two classes of
Mark, Winey, Kerry, Bloom
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The signalling lipid PI3,5P2 is essential for timely mitotic exit
Open Biology, 2023 Coordination of mitotic exit with chromosome segregation is key for successful mitosis. Mitotic exit in budding yeast is executed by the mitotic exit network (MEN), which is negatively regulated by the spindle position checkpoint (SPOC). SPOC kinase Kin4
Mariam Huda +3 more
doaj +1 more source