Results 41 to 50 of about 198,084 (294)

USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. [PDF]

PLoS ONE, 2018
Correct segregation of the mitotic chromosomes into daughter cells is a highly regulated process critical to safeguard genome stability. During M phase the spindle assembly checkpoint (SAC) ensures that all kinetochores are correctly attached before its ...
Anna Stockum, Ambrosius P Snijders, Goedele N Maertens   +2 more
doaj   +1 more source

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]

, 2003
We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Mayer, Thomas U., Erich A. Nigg, Francis A. Barr, Neef, Rüdiger, Josephine Sutcliffe, Kopajtich, R., Rüdiger Neef, Nigg, E. A., Robert Kopajtich, Mayer, T. U., Thomas U. Mayer, Christian Preisinger, Preisinger, C., Neef, R., Sutcliffe, J., Barr, F. A., Nigg, Erich A., Sutcliffe, Josephine, Kopajtich, Robert, Preisinger, Christian, Barr, Francis A.   +20 more
core   +1 more source

Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression

Scientific Reports, 2017
EG5 (KIF11) is a member of the kinesin-like protein family involved in centrosome separation and bipolar spindle formation. When a cell enters mitosis, CDK1 phosphorylates EG5 at Thr926 and promotes EG5 localization on the mitotic spindle which drives ...
Yang Liu, Zhong Zhang, Hui Liang, Xuyang Zhao, Ling Liang, Guangxi Wang, Jingyi Yang, Yan Jin, Michael A. McNutt, Yuxin Yin   +9 more
doaj   +1 more source

Asymmetry of the budding yeast Tem1 GTPase at spindle poles is required for spindle positioning but not for mitotic exit. [PDF]

PLoS Genetics, 2015
The asymmetrically dividing yeast S. cerevisiae assembles a bipolar spindle well after establishing the future site of cell division (i.e., the bud neck) and the division axis (i.e., the mother-bud axis).
Ilaria Scarfone, Marianna Venturetti, Manuel Hotz, Jette Lengefeld, Yves Barral, Simonetta Piatti   +5 more
doaj   +1 more source

Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target [PDF]

, 2011
The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping, Louwen, Frank, Sanhaji, Mourad, Friel, Claire T., Wordeman, Linda   +4 more
core   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B

Cell Reports, 2023
Summary: Matrin3 is an RNA-binding protein that regulates diverse RNA-related processes, including mRNA splicing. Although Matrin3 has been intensively studied in neurodegenerative diseases, its function in cancer remains unclear. Here, we report Matrin3-
Bruna R. Muys, Roshan L. Shrestha, Dimitrios G. Anastasakis, Lorinc Pongor, Xiao Ling Li, Ioannis Grammatikakis, Ahsan Polash, Raj Chari, Myriam Gorospe, Curtis C. Harris, Mirit I. Aladjem, Munira A. Basrai, Markus Hafner, Ashish Lal   +13 more
doaj   +1 more source

Force and Length in the Mitotic Spindle [PDF]

Current Biology, 2009
The mitotic spindle assembles to a steady-state length at metaphase through the integrated action of molecular mechanisms that generate and respond to mechanical forces. While molecular mechanisms that produce force have been described, our understanding of how they integrate with each other, and with the assembly/disassembly mechanisms that regulate ...
Dumont, Sophie, Mitchison, Timothy J.
openaire   +2 more sources

Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 [PDF]

, 2004
Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of ...
Erich A. Nigg, Francis A. Barr, Barr, FA, Neef, Rüdiger, Nigg, EA, Rüdiger Neef, Gruneberg, Ulrike, Honda, R, Ulrike Gruneberg, Nigg, Erich A., Neef, R, Reiko Honda, Honda, Reiko, Barr, Francis A.   +13 more
core   +1 more source

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

eLife, 2015
Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors.
Heidi Hehnly, David Canton, Paula Bucko, Lorene K Langeberg, Leah Ogier, Irwin Gelman, L Fernando Santana, Linda Wordeman, John D Scott   +8 more
doaj   +1 more source