Results 21 to 30 of about 130,672 (286)

New mitotic regulators released from chromatin

Frontiers in Oncology, 2013
Faithful action of the mitotic spindle segregates duplicated chromosomes into daughter cells. Perturbations of this process result in chromosome mis-segregation, leading to chromosomal instability and cancer development.
Hideki eYokoyama, Oliver eGruss
doaj   +1 more source

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]

, 2009
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Shobbir Hussain, Sandra Blanco Benavente, Elisabete Nascimento, Ilaria Dragoni, Agata Kurowski, Astrid Gillich, Peter Humphreys, Michaela Frye, Agris, Agris, Albee, Andersen, Andrews, Arnold, Blower, Blower, Boisvert, Brzezicha, Bujnicki, Clarke, Dephoure, Eliscovich, Frye, Frye, Gautier, Goshima, Greasley, Grosjean, Gruss, King, Liau, Ma, Nachury, Obara, Oeffinger, Raemaekers, Ribbeck, Rogakou, Sakita-Suto, Sato, Schmit, Schug, Taylor, Trieselmann, Tsai, Tscherne, Waikel, Watt, Wiese, Wu   +49 more
core   +1 more source

Characterization of ring-like F-actin structure as a mechanical partner for spindle positioning in mitosis. [PDF]

PLoS ONE, 2014
Proper spindle positioning and orientation are essential for accurate mitosis which requires dynamic interactions between microtubule and actin filament (F-actin).
Huan Lu, Qun Zhao, Hao Jiang, Tongge Zhu, Peng Xia, William Seffens, Felix Aikhionbare, Dongmei Wang, Zhen Dou, Xuebiao Yao   +9 more
doaj   +1 more source

Afadin orients cell division to position the tubule lumen in developing renal tubules [PDF]

, 2017
In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity in vivo is not known. We recently found the F-actin binding protein Afadin is required for lumen continuity in developing renal ...
Brakeman, Paul R., Bryant, David M., Gao, Lei, Hiremath, Chitkale, Long, Blake, Luby-Phelps, Katherine, Marciano, Denise K., Mostov, Keith E., Yang, Zhufeng, Zimmerman, Susan E.   +9 more
core   +2 more sources

Fission yeast cells undergo nuclear division in the absence of spindle microtubules. [PDF]

PLoS Biology, 2010
Mitosis in eukaryotic cells employs spindle microtubules to drive accurate chromosome segregation at cell division. Cells lacking spindle microtubules arrest in mitosis due to a spindle checkpoint that delays mitotic progression until all chromosomes ...
Stefania Castagnetti, Snezhana Oliferenko, Paul Nurse   +2 more
doaj   +1 more source

Microtubule organization within mitotic spindles revealed by serial block face scanning electron microscopy and image analysis [PDF]

, 2017
Serial block face scanning electron microscopy (SBF-SEM) is a powerful method to analyze cells in 3D. Here, working at the resolution limit of the method, we describe a correlative light-SBF-SEM workflow to resolve microtubules of the mitotic spindle in ...
Beckett, AJ, Brettschneider, JA, Clarke, NI, Honnor, TR, Johansen, AM, Nixon, FM, Prior, IA, Royle, SJ, Starling, GP   +8 more
core   +2 more sources

Meiotic cells escape prolonged spindle checkpoint activity through kinetochore silencing and slippage.

PLoS Genetics, 2023
To prevent chromosome mis-segregation, a surveillance mechanism known as the spindle checkpoint delays the cell cycle if kinetochores are not attached to spindle microtubules, allowing the cell additional time to correct improper attachments.
Anne MacKenzie, Victoria Vicory, Soni Lacefield   +2 more
doaj   +1 more source

Kinesins relocalize the chromosomal passenger complex to the midzone for spindle disassembly. [PDF]

, 2018
Mitotic spindle disassembly after chromosome separation is as important as spindle assembly, yet the molecular mechanisms for spindle disassembly are unclear.
Avunie-Masala, Buvelot, Cheeseman, Chen, Cleary, Cormier, Cottingham, David G. Drubin, Foiani, Fridman, Georjana Barnes, Gruneberg, Hoyt, Hoyt, Hsu, Itziar Ibarlucea-Benitez, Jaqaman, Kang, Khmelinskii, Kotwaliwale, Longtine, Luke S. Ferro, Morawska, Movshovich, Murata-Hori, Nakajima, Nakajima, Nicholas, Nishimura, Norden, Petersen, Reck-Peterson, Saunders, Saunders, Shannon, Straight, Tarantino, Thomas, Varga, Woodruff, Woodruff, Xing, Zhang, Zimniak   +43 more
core   +1 more source

HSP70 is required for the proper assembly of pericentriolar material and function of mitotic centrosomes

Cell Division, 2019
Background At the onset of mitosis, the centrosome expands and matures, acquiring enhanced activities for microtubule nucleation and assembly of a functional bipolar mitotic spindle.
Chieh-Ting Fang, Hsiao-Hui Kuo, Shao-Chun Hsu, Ling-Huei Yih   +3 more
doaj   +1 more source

Types of potentials in a mitotic spindle

Biochemistry and Biophysics Reports, 2021
The dynamics of a mitotic spindle is very important to understand if the functioning of mitosis has to be understood and defined very accurately. There are a number of forces involved in such a process.
Yelena Nemchen, Randal Hallford, Preet Sharma   +2 more
doaj   +1 more source