The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]
, 2009 Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Michaela Frye +15 more
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The mitotic spindle checkpoint [PDF]
Current Biology, 2001 Fantastic progress has been made in understanding the spindle checkpoint, the guardian of balanced chromosome segregation. However, several basic questions and many details remain to be worked out. In the meantime, the use of chimeric fluorescent proteins and ever better imaging technology has enhanced the stunning videos of mitosis made today ...
openaire +2 more sources
Expansion microscopy of the mitotic spindle [PDF]
, 2021 The mitotic spindle is a dynamic and complex cellular structure made of microtubules and associated proteins. Although the general localization of most proteins has been identified, the arrangement of the microtubules in the mitotic spindle and precise localization of various proteins are still under intensive research.
Ponjavić, Ivana +2 more
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Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly [PDF]
, 2009 Mitotic spindle formation and chromosome segregation depend critically on kinetochore-microtubule (KT-MT) interactions. A new protein, termed Spindly in Drosophila and SPDL-1 in C.
Erich A. Nigg +15 more
core +1 more source
New mitotic regulators released from chromatin
Frontiers in Oncology, 2013 Faithful action of the mitotic spindle segregates duplicated chromosomes into daughter cells. Perturbations of this process result in chromosome mis-segregation, leading to chromosomal instability and cancer development.
Hideki eYokoyama, Oliver eGruss
doaj +1 more source
Borealin : a novel chromosomal passenger required for stability of the bipolar mitotic spindle [PDF]
, 2004 The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex.
Erich A. Nigg +26 more
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Characterization of ring-like F-actin structure as a mechanical partner for spindle positioning in mitosis. [PDF]
PLoS ONE, 2014 Proper spindle positioning and orientation are essential for accurate mitosis which requires dynamic interactions between microtubule and actin filament (F-actin).
Huan Lu +9 more
doaj +1 more source
Bub3p facilitates spindle checkpoint silencing in fission yeast [PDF]
, 2009 Although critical for spindle checkpoint signaling, the role kinetochores play in anaphase promoting complex (APC) inhibition remains unclear. Here we show that spindle checkpoint proteins are severely depleted from unattached kinetochores in fission ...
Hardwick, Kevin G. +13 more
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Fission yeast cells undergo nuclear division in the absence of spindle microtubules. [PDF]
PLoS Biology, 2010 Mitosis in eukaryotic cells employs spindle microtubules to drive accurate chromosome segregation at cell division. Cells lacking spindle microtubules arrest in mitosis due to a spindle checkpoint that delays mitotic progression until all chromosomes ...
Stefania Castagnetti +2 more
doaj +1 more source
Human TPX2 is required for targeting Aurora-A kinase to the spindle [PDF]
, 2002 Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human Aurora-A binds to TPX2, a prominent component of the spindle apparatus.
Roman Körner +18 more
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