iScience, 2019 Summary: Cytoskeletal cross talk between actin filaments and microtubules is a common mechanism governing the assembly of cellular structures, i.e., during filopodia formation or cilia organization.
Matthias Plessner +2 more
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Palmitoylated importin α regulates mitotic spindle orientation through interaction with NuMA [PDF]
EMBO ReportsRegulation of cell division orientation is a fundamental process critical to differentiation and tissue homeostasis. Microtubules emanating from the mitotic spindle pole bind a conserved complex of proteins at the cell cortex which orients the spindle ...
Patrick James Sutton +2 more
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Journal of Cell Biology, 2012 The transition from a meiotic-like spindle formation characterized by lack of centrioles to a typical mitotic spindle occurs gradually in embryos during the preimplantation stage.
Jan Ellenberg +2 more
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CAMSAP2 is required for bridging fiber assembly to ensure mitotic spindle assembly and chromosome segregation in human epithelial Caco-2 cells. [PDF]
PLoS ONEIn mammalian epithelial cells, cytoplasmic microtubules are mainly non-centrosomal, through the functions of the minus-end binding proteins CAMSAP2 and CAMSAP3.
Naoko Nishizawa +4 more
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Contribution of cytoplasm viscoelastic properties to mitotic spindle positioning
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The regulation of mitotic spindle positioning is a key process for tissue architecture, embryo development, and stem cells. To date, most models have assumed that spindles are positioned by forces exerted by polar cytoskeleton networks, like
Jing Xie +6 more
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Timely Endocytosis of Cytokinetic Enzymes Prevents Premature Spindle Breakage during Mitotic Exit. [PDF]
PLoS Genetics, 2016 Cytokinesis requires the spatio-temporal coordination of membrane deposition and primary septum (PS) formation at the division site to drive acto-myosin ring (AMR) constriction.
Cheen Fei Chin +6 more
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The structure of the mitotic spindle and nucleolus during mitosis in the amebo-flagellate Naegleria. [PDF]
PLoS ONE, 2012 Mitosis in the amebo-flagellate Naegleria pringsheimi is acentrosomal and closed (the nuclear membrane does not break down). The large central nucleolus, which occupies about 20% of the nuclear volume, persists throughout the cell cycle.
Charles J Walsh
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The Drosophila microtubule-associated protein mars stabilizes mitotic spindles by crosslinking microtubules through its N-terminal region. [PDF]
PLoS ONE, 2013 Correct segregation of genetic material relies on proper assembly and maintenance of the mitotic spindle. How the highly dynamic microtubules (MTs) are maintained in stable mitotic spindles is a key question to be answered.
Gang Zhang +3 more
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Frontiers in Physiology, 2021 Mitosis proceeds through a defined series of events that is largely conserved, but the amount of time needed for their completion can vary in different cells and organisms.
Mathew Bloomfield +2 more
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Spatial and Temporal Scaling of Microtubules and Mitotic Spindles
Cells, 2022 During cell division, the mitotic spindle, a macromolecular structure primarily comprised of microtubules, drives chromosome alignment and partitioning between daughter cells.
Benjamin Lacroix, Julien Dumont
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