Results 31 to 40 of about 83,543 (230)

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]

, 2012
Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Surdo, N. C., Terrin, A., Sawa, A., N. E. Jordanides, A. Stangherlin, Monterisi, S., A. Terrin, Stefania Monterisi, Akira Sawa, Alessandra Stangherlin, Manuela Zaccolo, Joanne C. Mountford, Nicoletta C. Surdo, Niove E. Jordanides, Jordanides, N..E., Anna Zoccarato, Koschinski, A., MONGILLO, MARCO, Andreas Koschinski, Anna Terrin, M. Zaccolo, A. Koschinski, A. Zoccarato, Zoccarato, A., Zaccolo, M., A. Sawa, Mountford, J.C., N. C. Surdo, Marco Mongillo, Stangherlin, A., Mongillo, M., S. Monterisi, J. C. Mountford, Zoccarato Anna, Zaccolo Manuela, Surdo Nicoletta C, Koschinski Andreas, Mongillo Marco, Mountford Joanne C, Stangherlin Alessandra, Monterisi Stefania, Jordanides Niove E, Sawa Akira, Terrin Anna   +43 more
core   +1 more source

The Identification and Functional Analysis of mRNA Localizing to Centrosomes

Frontiers in Cell and Developmental Biology, 2021
Centrosomes are multifunctional organelles tasked with organizing the microtubule cytoskeleton required for genome stability, intracellular trafficking, and ciliogenesis.
Hala Zein-Sabatto, Dorothy A. Lerit
doaj   +1 more source

Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]

, 2011
Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Robert A. Cross, Kaseda, Kuniyoshi, Cross, R. A., Kuniyoshi Kaseda, McAinsh, Andrew D., Andrew D. McAinsh   +5 more
core   +1 more source

Mdm2-Mediated Downmodulation of GRK2 Restricts Centrosome Separation for Proper Chromosome Congression

Cells, 2021
The timing of centrosome separation and the distance moved apart influence the formation of the bipolar spindle, affecting chromosome stability. Epidermal growth factor receptor (EGFR) signaling induces early centrosome separation through downstream G ...
Clara Reglero, Belén Ortiz del Castillo, Verónica Rivas, Federico Mayor, Petronila Penela   +4 more
doaj   +1 more source

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 [PDF]

, 1998
Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans.
Fry, A. M., Erich A. Nigg, Stierhof, Y. D., Mayor, T., Y. D. Stierhof (7653686), Tanaka, K., Nigg, E. A., Meraldi, P., Thibault Mayor, A. M. Fry (7651490), E. A. Nigg (7651493), Kayoko Tanaka, Andrew M. Fry, P. Meraldi (7653683), K. Tanaka (1500880), Patrick Meraldi, York-Dieter Stierhof, T. Mayor (7653680), Meraldi P, Nigg EA, Fry AM, Tanaka K, Mayor T, Stierhof YD   +23 more
core   +1 more source

APC/CFZR-1 Controls SAS-5 Levels To Regulate Centrosome Duplication in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2017
As the primary microtubule-organizing center, centrosomes play a key role in establishing mitotic bipolar spindles that secure correct transmission of genomic content.
Jeffrey C. Medley, Lauren E. DeMeyer, Megan M. Kabara, Mi Hye Song   +3 more
doaj   +1 more source

The centrosome cycle

FEBS Letters, 2002
The centrosome is the major microtubule‐organizing center of animal cells. It influences cell shape and polarity and directs the formation of the bipolar mitotic spindle. Numerical and structural centrosome aberrations have been implicated in disease, notably cancer.
Meraldi, P., Nigg, E. A.
openaire   +3 more sources

Uncoupling of DNA Replication and Centrosome Duplication Cycles Is a Primary Cause of Haploid Instability in Mammalian Somatic Cells

Frontiers in Cell and Developmental Biology, 2020
Mammalian haploid somatic cells are unstable and prone to diploidize, but the cause of haploid instability remains largely unknown. Previously, we found that mammalian haploid somatic cells suffer chronic centrosome loss stemming from the uncoupling of ...
Koya Yoshizawa, Kan Yaguchi, Ryota Uehara, Ryota Uehara   +3 more
doaj   +1 more source

Centrosome Defects in Hematological Malignancies: Molecular Mechanisms and Therapeutic Insights

Blood Science, 2022
Defects in centrosomes are associated with a broad spectrum of hematological malignancies, such as leukemia and lymphoma. Centrosomes in these malignancies display both numerical and structural aberrations, including alterations in the number and size of
Mingzheng Hu, Yijie Wang, Jun Zhou
doaj   +1 more source

Centrosome polarization in T cells: A task for formins [PDF]

, 2013
T-cell antigen receptor (TCR) engagement triggers the rapid reorientation of the centrosome, which is associated with the secretory machinery, toward the immunological synapse (IS) for polarized protein trafficking.
Olga Maria Antón, Alonso, Miguel Angel, Andrés-Delgado, Laura, Alonso, Miguel A., Antón Hurtado, Olga María, Andrés-Delgado,Laura, Miguel Angel Alonso, Antón, Olga M., Laura Andrés-Delgado, Laura eAndrés-Delgado, Olga M. Antón   +10 more
core   +1 more source