Results 41 to 50 of about 83,543 (230)

ATAD5 suppresses centrosome over-duplication by regulating UAF1 and ID1 [PDF]

, 2020
Centrosomes are the primary microtubule-organizing centers that are important for mitotic spindle assembly. Centrosome amplification is commonly observed in human cancer cells and contributes to genomic instability.
Kim, Shinseog, Kyoo-young Lee, Kim, Tae Moon, Park, Su Hyung, Park, Jun Hong, Kim, Seong-jung, Kyungjae Myung, Su Hyung Park, Myung, Kyungjae, Jun Hong Park, Seong-jung Kim, Lee, Kyoo-young, Tae Moon Kim, Shinseog Kim, Minwoo Wie, Wie, Minwoo   +15 more
core   +1 more source

Proteins implicated in muscular dystrophy and cancer are functional constituents of the centrosome

Life Science Alliance, 2022
This study demonstrates that the muscular dystrophy-associated proteins dystrophin, utrophin, dysferlin, and calpain-3 localize to the centrosome and that their absence leads to excess centrosomes, compromised nuclear morphology, impaired centrosome ...
Lilli Winter, Monika Kustermann, Büsra Ernhofer, Harald Höger, Reginald E Bittner, Wolfgang M Schmidt   +5 more
doaj   +1 more source

A Proximity Mapping Journey into the Biology of the Mammalian Centrosome/Cilium Complex

Cells, 2020
The mammalian centrosome/cilium complex is composed of the centrosome, the primary cilium and the centriolar satellites, which together regulate cell polarity, signaling, proliferation and motility in cells and thereby development and homeostasis in ...
Melis Dilara Arslanhan, Dila Gulensoy, Elif Nur Firat-Karalar   +2 more
doaj   +1 more source

Excess centrosomes disrupt endothelial cell migration via centrosome scattering [PDF]

, 2014
Centrosome–microtubule interactions during interphase are important for centrosome clustering and cell polarity.Supernumerary centrosomes contribute to spindle defects and aneuploidy at mitosis, but the effects of excess centrosomes during interphase are
Jie-Yu Liu, Liu, Jie Yu, Erich J. Kushner, Ferro, Luke S., Dudley, Andrew C., Durrant, Jessica R., Stephen L. Rogers, Rogers, Stephen L., Luke S. Ferro, Bautch, Victoria L., Jessica R. Durrant, Victoria L. Bautch, Kushner, Erich J., Andrew C. Dudley   +13 more
core   +1 more source

Epigenetic alterations impede epithelial-mesenchymal transition by modulating centrosome amplification and Myc/RAS axis in triple negative breast cancer cells

Scientific Reports, 2023
Alterations in centrosome proteins may result in centrosome abnormalities such as disorganized spindles and centrosome amplification, leading to aneuploidy and genomic instability.
Laxmidhar Das
doaj   +1 more source

FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1

Biology Open, 2013
Summary DNA damage response (DDR) and the centrosome cycle are two of the most critical processes for maintaining a stable genome in animals. Sporadic evidence suggests a connection between these two processes.
Jianqiu Zou, Fen Tian, Ji Li, Wyatt Pickner, Molly Long, Khosrow Rezvani, Hongmin Wang, Dong Zhang   +7 more
doaj   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

NUCLEOLI AND CENTROSOMES [PDF]

Annals of Botany, 1894
n ...
openaire   +2 more sources

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

An intact centrosome is required for the maintenance of polarization during directional cell migration.

PLoS ONE, 2010
BackgroundEstablishing and maintaining polarization is critical during cell migration. It is known that the centrosome contains numerous proteins whose roles of organizing the microtubule network range include nucleation, stabilization and severing.
Nicole M Wakida, Elliot L Botvinick, Justin Lin, Michael W Berns   +3 more
doaj   +1 more source