Results 41 to 50 of about 82,885 (231)

IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning

Nature Communications, 2017
Cytokinesis relies on central spindle organization and provides a spatial landmark for lumen formation. Here, the authors show that intraflagellar transport proteins are required for the localization of the cytokinetic regulator Aurora B and subsequent ...
Nicolas Taulet, Benjamin Vitre, Christelle Anguille, Audrey Douanier, Murielle Rocancourt, Michael Taschner, Esben Lorentzen, Arnaud Echard, Benedicte Delaval   +8 more
doaj   +1 more source

Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila

Biology Open, 2012
Summary Centrosome defects are a common feature of many cancers, and they can predispose fly brain cells to form tumours. In flies, centrosome defects perturb the asymmetric division of the neural stem cells, but it is unclear how this might lead to ...
Janina Baumbach, Mitchell P. Levesque, Jordan W. Raff   +2 more
doaj   +1 more source

Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly [PDF]

, 2009
In animal somatic cells, bipolar spindle formation requires separation of the centrosome-based spindle poles. Centrosome separation relies on multiple pathways, including cortical forces and antiparallel microtubule (MT) sliding, which are two activities
Winter, Jennifer R., Toso, Alberto, Ainslie J. Garrod, Garrod, Ainslie J., Alberto Toso, Jennifer R. Winter, Ana C. Amaro, Patrick Meraldi, Amaro, Ana C., McAinsh, Andrew D., Meraldi, Patrick, Andrew D. McAinsh   +11 more
core   +1 more source

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 [PDF]

, 1998
Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans.
Fry, A. M., Erich A. Nigg, Stierhof, Y. D., Mayor, T., Y. D. Stierhof (7653686), Tanaka, K., Nigg, E. A., Meraldi, P., Thibault Mayor, A. M. Fry (7651490), E. A. Nigg (7651493), Kayoko Tanaka, Andrew M. Fry, P. Meraldi (7653683), K. Tanaka (1500880), Patrick Meraldi, York-Dieter Stierhof, T. Mayor (7653680)   +17 more
core   +1 more source

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]

, 2012
Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Stangherlin, A, Surdo, N. C., Terrin, A., Sawa, A., Terrin, A, N. E. Jordanides, A. Stangherlin, Monterisi, S, Mountford, JC, Monterisi, S., A. Terrin, Surdo, NC, Stefania Monterisi, Akira Sawa, Mongillo, M, Jordanides, NE, Alessandra Stangherlin, Koschinski, A, Manuela Zaccolo, Joanne C. Mountford, Nicoletta C. Surdo, Niove E. Jordanides, Jordanides, N..E., Anna Zoccarato, Koschinski, A., Zaccolo, Manuela, MONGILLO, MARCO, Andreas Koschinski, Anna Terrin, M. Zaccolo, Sawa, A, A. Koschinski, A. Zoccarato, Zoccarato, A., Zaccolo, M., A. Sawa, Mountford, J.C., Zoccarato, A, N. C. Surdo, Marco Mongillo, Stangherlin, A., Mongillo, M., S. Monterisi, J. C. Mountford   +43 more
core   +1 more source

The Identification and Functional Analysis of mRNA Localizing to Centrosomes

Frontiers in Cell and Developmental Biology, 2021
Centrosomes are multifunctional organelles tasked with organizing the microtubule cytoskeleton required for genome stability, intracellular trafficking, and ciliogenesis.
Hala Zein-Sabatto, Dorothy A. Lerit
doaj   +1 more source

Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]

, 2011
Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Robert A. Cross, Kaseda, Kuniyoshi, Cross, R. A., Kuniyoshi Kaseda, McAinsh, Andrew D., Andrew D. McAinsh   +5 more
core   +1 more source

Mdm2-Mediated Downmodulation of GRK2 Restricts Centrosome Separation for Proper Chromosome Congression

Cells, 2021
The timing of centrosome separation and the distance moved apart influence the formation of the bipolar spindle, affecting chromosome stability. Epidermal growth factor receptor (EGFR) signaling induces early centrosome separation through downstream G ...
Clara Reglero, Belén Ortiz del Castillo, Verónica Rivas, Federico Mayor, Petronila Penela   +4 more
doaj   +1 more source

APC/CFZR-1 Controls SAS-5 Levels To Regulate Centrosome Duplication in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2017
As the primary microtubule-organizing center, centrosomes play a key role in establishing mitotic bipolar spindles that secure correct transmission of genomic content.
Jeffrey C. Medley, Lauren E. DeMeyer, Megan M. Kabara, Mi Hye Song   +3 more
doaj   +1 more source

Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates [PDF]

, 2012
Protein kinases are important regulators of signal transduction pathways in both unicellular and multicellular organisms. They play critical roles in biological processes such as cell growth, division, differentiation, adhesion, motility and cell death ...
Kohler, Reto
core   +1 more source