Results 61 to 70 of about 82,885 (231)
Investigation of human centrosomes - with a special focus on the function of Cep152 and Cep192 in centriole duplication [PDF]
, 2012 Centrioles are symmetrical, barrel-shaped, microtubule-based structures, that serve as building platforms for the formation of centrosomes and cilia. In dividing cells, they recruit a matrix of proteins called pericentriolar material (PCM) to form the ...
Sonnen, Katharina Friederike
core +1 more source
Biology Open, 2013 Summary DNA damage response (DDR) and the centrosome cycle are two of the most critical processes for maintaining a stable genome in animals. Sporadic evidence suggests a connection between these two processes.
Jianqiu Zou +7 more
doaj +1 more source
Centrosome polarization in T cells: A task for formins [PDF]
, 2013 T-cell antigen receptor (TCR) engagement triggers the rapid reorientation of the centrosome, which is associated with the secretory machinery, toward the immunological synapse (IS) for polarized protein trafficking.
Olga Maria Antón +10 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Centrosome-intrinsic mechanisms modulate centrosome integrity during fever [PDF]
, 2019 The centrosome is critical for cell division, ciliogenesis, membrane trafficking, and immunological synapse function. The immunological synapse is part of the immune response, which is often accompanied by fever/heat stress (HS). Here we provide evidence
Vertii, Anastassiia +3 more
core +1 more source
, 2009 To investigate changes at the centrosome during the cell cycle,we analyzed the composition of the pericentriolar materialfrom unsynchronized and S-phase-arrested cells by gelelectrophoresis and mass spectrometry.
Haren, Laurence +3 more
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PLoS ONE, 2010 BackgroundEstablishing and maintaining polarization is critical during cell migration. It is known that the centrosome contains numerous proteins whose roles of organizing the microtubule network range include nucleation, stabilization and severing.
Nicole M Wakida +3 more
doaj +1 more source
Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells
Cancer Medicine, 2023 Background Unlike normal cells, cancer cells frequently have multiple centrosomes that can cluster to form bipolar mitotic spindles and allow for successful cell division.
Jose Thaiparambil +4 more
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Characterization of the RhoGAP proteins RGA-3 and RGA-4 and the centrosomal protein SAS-5 in the early "Caenorhabditis elegans" embryo [PDF]
, 2007 The Caenorhabditis elegans embryo serves as a great tool to study cell biological processes like polarization and cell divison. The first cell division is unequal and cell polarization is dependant on the Rho GTPase regulated rearrangement of the cell ...
Schmutz, Cornelia
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