Results 71 to 80 of about 77,614 (192)

DNA damage induces Chk1-dependent centrosome amplification [PDF]

, 2007
Centrosomal abnormalities are frequently observed in cancers and in cells with defective DNA repair. Here, we used light and electron microscopy to show that DNA damage induces centrosome amplification, not fragmentation, in human cells.
Bourke, E., Zachos, G., Andreas Merdes, Gillespie, D., Emer Bourke, Cuffe, L., Helen Dodson, Morrison, C.G., Lorraine Cuffe, Dodson, H., David Gillespie, Mark Walker, Ciaran G. Morrison, Merdes, A., Walker, M., George Zachos, Ciaran G Morrison   +16 more
core   +1 more source

CP91 is a component of the Dictyostelium centrosome involved in centrosome biogenesis

European Journal of Cell Biology, 2016
The Dictyostelium centrosome is a model for acentriolar centrosomes and it consists of a three-layered core structure surrounded by a corona harboring microtubule nucleation complexes. Its core structure duplicates once per cell cycle at the G2/M transition.
Putzler, Sascha, Meyer, Irene, Gräf, Ralph   +2 more
openaire   +2 more sources

An ATM and ATR dependent checkpoint inactivates spindle assembly by targeting CEP63

, 2010
The effects of ATM and ATR signalling induced by chromosomal breakage have been described extensively in modulating cell cycle progression up to the onset of mitosis.
Smith, E.A.
core  

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 3, Page 362-373, June 2026.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Delayed centrosome maturation causes asymmetric particle partitioning.

, 2012
(A) Time series of dynein distribution with ∼1 hr time delay between the centrosome maturation (also see Movie S3). During the simulated duration of 3000 s, the number of microtubules organized by the dominant centrosome increases from 200 to 800.
Jennifer Lippincott-Schwartz (171711), Jian Liu (33711), Jing Chen (4762)   +2 more
core   +1 more source

Interphase centrosome organization by the PLP-Cnn scaffold is required for centrosome function

, 2015
Cnn and PLP directly interact at two defined sites to coordinate the cell cycle–dependent rearrangement and scaffolding activity of the centrosome to permit normal centrosome organization, cell division, and embryonic viability.Pericentriolar material ...
Poulton, John S., Galletta, Brian J., Rusan, Nasser M., Nasser M. Rusan, Jordan, Holly A., Dorothy A. Lerit, Mark Peifer, John S. Poulton, Fagerstrom, Carey J., Lerit, Dorothy A., Brian J. Galletta, Peifer, Mark, Holly A. Jordan, Carey J. Fagerstrom   +13 more
core   +1 more source

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, Volume 293, Issue 11, Page 3140-3165, June 2026.
Intra‐tumoral oxygen deprivation (hypoxia) promotes the activation of hypoxia‐inducible factors (HIFs) that orchestrate the transcriptional adaptation of cancer cells to hypoxia. Hypoxia is prevalent in hepatocellular carcinoma (HCC), a cancer type with limited therapeutic options.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

Rethinking the role of HIF in hepatocellular carcinoma

The FEBS Journal, Volume 293, Issue 11, Page 3131-3134, June 2026.
Tumor hypoxia is a hallmark of cancer driving disease, in part through activation of hypoxia‐inducible factors (HIFs). While HIF‐1α is classically understood as a hypoxia‐responsive transcription factor, its role under normoxic conditions in cells is less clear.
Niall S. Kenneth, Michael Batie, Sonia Rocha   +2 more
wiley   +1 more source

GM130 controls Golgi-centrosome proximity.

, 2019
A. Wild-type and GM130 KO cells were stained for γ-tubulin and Golgin-84 to visualize the centrosome and the Golgi, respectively. B. Left: Graph showing the percentage of cells with increased Golgi (GA)—centrosome distance.
Kati Tormanen (6589415), Christine Sütterlin (145832), Kevin Wang (253690), Celine Ton (6589418), Barbara M. Waring (6589421)   +4 more
core   +1 more source