Results 81 to 90 of about 72,372 (185)

HSP70 is required for the proper assembly of pericentriolar material and function of mitotic centrosomes

Cell Division, 2019
Background At the onset of mitosis, the centrosome expands and matures, acquiring enhanced activities for microtubule nucleation and assembly of a functional bipolar mitotic spindle.
Chieh-Ting Fang, Hsiao-Hui Kuo, Shao-Chun Hsu, Ling-Huei Yih   +3 more
doaj   +1 more source

LRRC45 Is a Centrosome Linker Component Required for Centrosome Cohesion

Cell Reports, 2013
During interphase, centrosomes are connected by a proteinaceous linker between the proximal ends of the centrioles, which is important for the centrosomes to function as a single microtubule-organizing center. However, the composition and regulation of centrosomal linker remain largely unknown.
Runsheng He, Ning Huang, Yitian Bao, Haining Zhou, Junlin Teng, Jianguo Chen   +5 more
openaire   +3 more sources

The LINC complex ensures accurate centrosome positioning during prophase

Life Science Alliance
Centrosome positioning in prophase is essential for efficient spindle assembly. Here, we show that centrosome positioning requires LINC complex–mediated loading of dynein on the nuclear envelope.
Joana T Lima, António J Pereira, Jorge G Ferreira   +2 more
doaj   +1 more source

New insights into subcomplex assembly and modifications of centrosomal proteins

Cell Division, 2012
This review provides a brief overview of the recent work on centrosome proteomics, protein complex identification and functional characterization with an emphasis on the literature of the last three years.
Habermann Karin, Lange Bodo MH
doaj   +1 more source

CP91 is a component of the Dictyostelium centrosome involved in centrosome biogenesis

European Journal of Cell Biology, 2016
The Dictyostelium centrosome is a model for acentriolar centrosomes and it consists of a three-layered core structure surrounded by a corona harboring microtubule nucleation complexes. Its core structure duplicates once per cell cycle at the G2/M transition.
Putzler, Sascha, Meyer, Irene, Gräf, Ralph (Prof. Dr.)   +2 more
openaire   +2 more sources

Asymmetry in centrosome maturation revealed through AIR-1 dynamics in the early Caenorhabditis elegans embryo

Scientific Reports
Centrosomes are critical organelles associated with the nucleus, consisting of a pair of centrioles surrounded by a cloud of pericentriolar material. They serve as key nucleation sites for microtubule arrays and are essential for positioning the nucleus ...
Shayne M. Plourde, Natalia Kravtsova, Adriana T. Dawes   +2 more
doaj   +1 more source

Inhibiting centrosome clustering reduces cystogenesis and improves kidney function in autosomal dominant polycystic kidney disease

JCI Insight
Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder accounting for approximately 5% of patients with renal failure, yet therapeutics for the treatment of ADPKD remain limited. ADPKD tissues display abnormalities in the biogenesis
Tao Cheng, Aruljothi Mariappan, Ewa Langner, Kyuhwan Shim, Jay Gopalakrishnan, Moe R. Mahjoub   +5 more
doaj   +1 more source

Oxidative stress and serum deprivation influence the evolution of newly formed tetraploid cells during tumorigenesis. [PDF]

Proc Natl Acad Sci U S A
Sweet ML, Bloomfield M, Keen N, Bano N, Pan X, Baudoin NC, Udayasuryan B, Ahmad RN, Riddervold E, Klaiber E, Verbridge SS, Schmelz EM, Chen J, Cimini D.   +13 more
europepmc   +1 more source

Distinct D-box motifs in SPD-2 mediate APC/CFZR-1-dependent degradation and centrosomal localization in Caenorhabditis elegans embryos. [PDF]

G3 (Bethesda)
Yim RN, DiPanni JR, Rivera PA, Song MH.
europepmc   +1 more source

Indium (III) chloride inhibits testicular Leydig cell proliferation by disrupting centrosome copy numbers. [PDF]

Mol Med Rep
Wang CY, Su PJ, Wang KC, Lin RC, Ke MY, Teng YN.   +5 more
europepmc   +1 more source