Results 81 to 90 of about 77,614 (192)

Hypoxia-Induced Centrosome Loss in Epithelial Cells

, 2022
Centrosome loss has recently been reported as a phenotype of prostate cancer. Hypoxia, an environmental condition seen commonly in prostate cancer, can cause centrosome loss in the immortalized prostate epithelial cell line, RWPE1.
Loertscher, Emily
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The arithmetic of centrosome biogenesis [PDF]

How do cells regulate centrosome number? A canonical duplication cycle generates two centrosomes from one in most proliferating cells. Centrioles are key to this process, and molecules such as centrins, SAS-4 and ZYG-1 govern daughter centriole formation.
Delattre, Marie, Gönczy, Pierre
core   +1 more source

Centrosome and retroviruses: The dangerous liaisons

, 2007
Centrosomes are the major microtubule organizing structures in vertebrate cells. They localize in close proximity to the nucleus for the duration of interphase and play major roles in numerous cell functions.
Saïb, Ali, Zamborlini Alessia, Ali Saïb, Philippe V Afonso, Zamborlini, Alessia, Renaud Mahieux, Mahieux, Renaud, Saïb Ali, Afonso, Philippe V, Alessia Zamborlini, Mahieux Renaud, Afonso Philippe V, Philippe V Afonso   +12 more
core   +1 more source

Centrosome isolation from cultured bladder cancer cells--p53 mutation and centrosome hyperamplification [PDF]

, 2003
膀胱癌細胞株を用いて中心体の分離を試み, 中心体複製周期をコントロールするnucleophosmin/B23(NPM)の中心体の局在を検討した.ヒト膀胱癌細胞株(RT-4, HT-1197, HT-1376)を用いた.RT-4は中心体の複製周期が保たれている細胞株であり, HT-1197, HT-1376は中心体過剰複製を認める細胞株であった.HT-1197, HT-1376においては, 3個以上の中心体も観察できた.RT-4とHT-1197において ...
森山, 学, 芝, 延行, 菅, 幸大, 田中, 達朗, 鈴木, 孝治, 池田, 龍介, 川村, 研二   +6 more
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Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis

, 2015
Nek5 is a poorly characterized member of the NIMA-related kinase family, other members of which play roles in cell cycle progression and primary cilia function.
Navdeep K. Sahota (7607171), Fry, Andrew M., L. Pelletier (7656122), Suzanna L. Prosser, Prosser, Suzanna L., Navdeep K. Sahota, Morrison, Ciaran G., Suzanna L. Prosser (7641353), Laurence Pelletier, Andrew M. Fry, Ciaran G. Morrison, C. G. Morrison (7656125), Pelletier, Laurence, Andrew M. Fry (7589357), Sahota, Navdeep K.   +14 more
core   +1 more source

Peripheral, Non-Centrosome-Associated Microtubules Contribute to Spindle Formation in Centrosome-Containing Cells

, 2003
In centrosome-containing cells, microtubules utilized in spindle formation are thought to be nucleated at the centrosome. However, spindle formation can proceed following experimental destruction of centrosomes [1] or in cells lacking centrosomes [2 ...
Tulu, US, Wadsworth, P., Tulu, U.S., Wadsworth, P, Rusan, N.M., Rusan, NM   +5 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Molecular mechanisms underlying centrosome disjunction

, 2019
As a major microtubule-organizing center in mammalian cells, the centrosome consists of two centrioles that are surrounded by the pericentriolar material.
Au, Kin Chung Franco
core  

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in g2 phase after dna damage

, 2018
DNA damage can induce centrosome overduplication in a manner that requires G2-to-M checkpoint function, suggesting that genotoxic stress can decouple the centrosome and chromosome cycles. How this happens is unclear. Using live-cell imaging of cells that
Morrison, C. G., Inanc, B., Dodson, H.
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