Results 81 to 90 of about 83,543 (230)

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

The centrosome is an actin-organizing centre.

, 2016
International audienceMicrotubules and actin filaments are the two main cytoskeleton networks supporting intracellular architecture and cell polarity.
Sillibourne, James, James Sillibourne, Francesca Farina, Guérin, Christophe, Gaillard, Jérémie, Jérémie Gaillard, Blanchoin, Laurent, Couté, Yohann, Manuel Théry, Farina, Francesca, Yohann Couté, Théry, Manuel, Christophe Guérin, Laurent Blanchoin   +13 more
core   +1 more source

Acto-myosin network geometry defines centrosome position

, 2021
International audienceThe centrosome is the main organizer of microtubules and as such, its position is a key determinant of polarized cell functions.
Letort, Gaëlle, Piel, Matthieu, Jimenez, Ana Joaquina, de Pascalis, Chiara, Vianay, Benoit, Théry, Manuel, Bornens, Michel, Schaeffer, Alexandre, Blanchoin, Laurent, Chiara De Pascalis, Michel Bornens, Gaëlle Letort, Manuel Théry, Ana Joaquina Jimenez, Alexandre Schaeffer, Matthieu Piel, Benoit Vianay, Laurent Blanchoin   +17 more
core   +1 more source

Cep120 is essential for kidney stromal progenitor cell growth and differentiation

EMBO Reports, 2023
Mutations in genes that disrupt centrosome structure or function can cause congenital kidney developmental defects and lead to fibrocystic pathologies. Yet, it is unclear how defective centrosome biogenesis impacts renal progenitor cell physiology. Here,
Ewa Langner, Tao Cheng, Eirini Kefaloyianni, Charles Gluck, Baolin Wang, Moe R Mahjoub   +5 more
doaj   +1 more source

Hyaluronan‐Mediated Motility Receptor Potentiates Colorectal Carcinoma Progression Through PI3K/AKT/mTOR Pathway Modulation

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Hyaluronan‐mediated motility receptor (HMMR) promotes colorectal cancer progression by enhancing proliferation, migration, and invasion through activation of the PI3K/AKT/mTOR pathway. Targeting HMMR effectively suppresses these malignant phenotypes, highlighting its potential as a promising therapeutic target in colorectal carcinoma.
Cheng Shi, Yu Chen, Xinyu Hu, Fujin Jin, Qi Liu, Chongbin Ou, Yecai Lu   +6 more
wiley   +1 more source

Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species

Andrology, EarlyView.
ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak, Brian J. Galletta, Nasser M. Rusan   +2 more
wiley   +1 more source

Rare Novel Genetic Variants of the OFD1 Gene Associated With a Familial Form and a Sporadic Case of Long Bone Atypical Fractures

Clinical Genetics, EarlyView.
A novel rare variant of the OFD1 gene was identified in a family with dental hypoplasia, facial hypoplasia, and adult‐onset multiple atypical fractures of long bones. Another variant of the OFD1 gene was found in a woman with bisphosphonate‐associated atypical femur fracture.
Marie‐Ève Boisvert, Halim Maaroufi, Rachel Laframboise, Frédéric Fournier, Suzanne N. Morin, Edith Gagnon, Claudia Gagnon, Fabrice Mac‐Way, Mahmoud Rouabhia, Louis‐Georges Ste‐Marie, Arnaud Droit, Jacques P. Brown, Laëtitia Michou   +12 more
wiley   +1 more source

GM130 controls Golgi-centrosome proximity.

, 2019
A. Wild-type and GM130 KO cells were stained for γ-tubulin and Golgin-84 to visualize the centrosome and the Golgi, respectively. B. Left: Graph showing the percentage of cells with increased Golgi (GA)—centrosome distance.
Kati Tormanen (6589415), Christine Sütterlin (145832), Kevin Wang (253690), Celine Ton (6589418), Barbara M. Waring (6589421)   +4 more
core   +1 more source

Brief encounters and lasting impressions—How target protein half‐life affects reactive metabolite signaling

The FEBS Journal, EarlyView.
Lipid‐derived reactive electrophile molecules (REMs) are generated from fatty acids through lipoxygenase or cyclooxygenase‐assisted catalysis, or free radical‐induced lipid peroxidation events. REMs so‐produced covalently modify nearby protein‐cysteines, and in the case of ‘first responder’ proteins, can trigger gain‐of‐function signaling with context ...
Marcus J. C. Long, Lorna Birkby, Yimon Aye   +2 more
wiley   +1 more source