Results 101 to 110 of about 83,543 (230)

The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication

Nature Communications
Copy number control of DNA and centrosomes is essential for accurate genetic inheritance. DNA replication and centrosome duplication have been recognized as parallel key events for cell division.
Kyohei Matsuhashi, Kei K. Ito, Kaho Nagai, Akira Sanada, Koki Watanabe, Kasuga Takumi, Atsushi Toyoda, Masamitsu Fukuyama, Shohei Yamamoto, Takumi Chinen, Grant S. Stewart, Shoji Hata, Daiju Kitagawa   +12 more
doaj   +1 more source

Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley   +1 more source

Centrosome – a promising anti-cancer target

, 2016
Yainyrette Rivera-Rivera, Harold I Saavedra Department of Pharmacology, Ponce Health Sciences University-School of Medicine, Ponce Research Institute, Ponce, Puerto Rico Abstract: The centrosome, an organelle discovered >100 years ago, is the ...
Rivera-Rivera Y, Saavedra HI
core  

A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis

iScience, 2019
Summary: Whole-genome doubling (WGD) is common early in tumorigenesis. WGD doubles ploidy and centrosome number. In the ensuing mitoses, excess centrosomes form a multipolar spindle, resulting in a lethal multipolar cell division.
Noelle V. Antao, Marina Marcet-Ortega, Paolo Cifani, Alex Kentsis, Emily A. Foley   +4 more
doaj   +1 more source

Major Depressive Disorder With Non‐Suicidal Self‐Injury in Adolescents: Altered Morphological Inverse Divergence Gradient in Brain Structure and Gene Expression Patterns

Human Brain Mapping, Volume 47, Issue 15, October 15, 2026.
Using the morphometric inverse divergence gradient network (MIND‐Gd), this study shows that adolescents with major depressive disorder (MDD) and non‐suicidal self‐injury (NSSI) exhibit altered principal structural gradients relative to adolescents with MDD without NSSI, and that these gradient changes are spatially coupled to neurotransmitter receptor ...
Yan Zhang, Xinyuan Hu, Wei Wang, Jing Wang, Hongying Li, Yumei Wan, Jianlei Zhu, Fei Liu, Shiyue Tao, Duanwei Wang, Xiangtao Lin, Yingying Zhang, Hongmei Zhang, Yuandong Gong   +13 more
wiley   +1 more source

Beta‐Arrestin‐2 Binds to Nucleolar Organizing Regions With P2X7 Receptor Stimulation and During Cell Division

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Beta‐Arrestin‐2 but not Beta‐Arrestin‐1 can accumulate in the nucleolus and come in close contact with the Nucleolar Organizing Regions during two distinct processes: P2X7 receptor stimulation (A) and cell division (B). Both seem to be due to loss of nuclear membrane barrier that keeps Beta‐arrestin‐2 out of the nucleus.
Tuğba Gümüştaş, Seda Uysal, Ida Casella, Özlem Uğur, Mehmet Uğur   +4 more
wiley   +1 more source

Centrosome Remodelling in Evolution

, 2018
The centrosome is the major microtubule organizing centre (MTOC) in animal cells. The canonical centrosome is composed of two centrioles surrounded by a pericentriolar matrix (PCM).
Daisuke Ito, Mónica Bettencourt-Dias
core   +1 more source

Centrosome and retroviruses: The dangerous liaisons

Retrovirology, 2007
Centrosomes are the major microtubule organizing structures in vertebrate cells. They localize in close proximity to the nucleus for the duration of interphase and play major roles in numerous cell functions.
Mahieux Renaud, Saïb Ali, Zamborlini Alessia, Afonso Philippe V   +3 more
doaj   +1 more source

Amorphous no longer: the centrosome comes into focus

, 2008
Recent genetic and biochemical studies have provided new insights into the molecular basis of centrosome-mediated microtubule nucleation. In addition, molecules and mechanisms involved in microtubule severing and stabilization at the centrosome, assembly
Zimmerman, Wendy Cherie, Sparks, Cynthia A., Doxsey, Stephen J.   +2 more
core   +1 more source

Van Beneden and the Origin of the Centrosome.--A Correction

, 1897
VAN BENEDEN AND THE ORIGIN OF THE CENTROSOME.--A CORRECTION Van Beneden and the Origin of the Centrosome.--A Correction (5) (-
Wilson, Edmund B.
core   +1 more source