Results 101 to 110 of about 82,885 (231)

Interphase centrosome organization by the PLP-Cnn scaffold is required for centrosome function [PDF]

, 2015
Cnn and PLP directly interact at two defined sites to coordinate the cell cycle–dependent rearrangement and scaffolding activity of the centrosome to permit normal centrosome organization, cell division, and embryonic viability.Pericentriolar material ...
Poulton, John S., Galletta, Brian J., Rusan, Nasser M., Nasser M. Rusan, Jordan, Holly A., Dorothy A. Lerit, Mark Peifer, John S. Poulton, Fagerstrom, Carey J., Lerit, Dorothy A., Brian J. Galletta, Peifer, Mark, Holly A. Jordan, Carey J. Fagerstrom   +13 more
core   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species

Andrology, EarlyView.
ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak, Brian J. Galletta, Nasser M. Rusan   +2 more
wiley   +1 more source

Rare Novel Genetic Variants of the OFD1 Gene Associated With a Familial Form and a Sporadic Case of Long Bone Atypical Fractures

Clinical Genetics, EarlyView.
A novel rare variant of the OFD1 gene was identified in a family with dental hypoplasia, facial hypoplasia, and adult‐onset multiple atypical fractures of long bones. Another variant of the OFD1 gene was found in a woman with bisphosphonate‐associated atypical femur fracture.
Marie‐Ève Boisvert, Halim Maaroufi, Rachel Laframboise, Frédéric Fournier, Suzanne N. Morin, Edith Gagnon, Claudia Gagnon, Fabrice Mac‐Way, Mahmoud Rouabhia, Louis‐Georges Ste‐Marie, Arnaud Droit, Jacques P. Brown, Laëtitia Michou   +12 more
wiley   +1 more source

Tetraploidy-associated centrosome overduplication in mouse early embryos

Communicative & Integrative Biology, 2018
Recently, we observed that tetraploidization of certain types of human cancer cells resulted in upregulation of centrosome duplication cycles and chronic generation of the extra centrosome. Here, we investigated whether tetraploidy-linked upregulation of
Kan Yaguchi, Takahiro Yamamoto, Ryo Matsui, Masaya Shimada, Atsuko Shibanuma, Keiko Kamimura, Toshiaki Koda, Ryota Uehara   +7 more
doaj   +1 more source

HTLV-1 Tax: centrosome amplification and cancer

Retrovirology, 2006
During interphase, each cell contains a single centrosome that acts as a microtubule organizing center for cellular functions in interphase and in mitosis.
Kashanchi Fatah, de la Fuente Cynthia, Pumfery Anne   +2 more
doaj   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics

, 2023
The centrosome is a dynamic structure that undergoes structural and functional transitions, which are coordinated with the cell cycle. It functions as the microtubule organizing center (MTOC) in interphase, duplicates and separates in S-G 2 forms the ...
NC DOCKS at East Carolina University, DeVaul, Nicole   +1 more
core  

Cooccurrence of Homologous Recombination Deficiency and Mismatch Repair Deficiency in Colorectal Cancer

MedComm, Volume 7, Issue 10, October 2026.
Cooccurrence of dMMR and HRD in colorectal cancer. On the left blue shaded area, the dMMR (deficient mismatch repair) pathway is shown as a result of the loss of key DNA repair genes MLH1, MSH2, MSH6, and PMS2, which cause single strand breaks.
Xu Zhang, Hao Xu, Kailai Wang, Wangxiong Hu   +3 more
wiley   +1 more source

The centrosome [PDF]

Current Biology, 1999
Urbani, Lenore, Stearns, Tim
openaire   +2 more sources