Results 121 to 130 of about 83,543 (230)

PPP1R2 COORDINATES KINASE AND PHOSPHATASE ACTIVITY TO REGULATE THE CENTROSOME AND MIDBODY

, 2023
Centrosomes are the primary microtubule organizing centers of the cell and prepare the cell for division by establishing the bipolar spindle during mitosis.
Bresch, Alan-Michael, NC DOCKS at East Carolina University   +1 more
core  

Centrosome duplication and nematodes: recent insights from an old relationship

, 2005
Centrosome duplication is required for proper cell division, and centriole formation is a key step in this process. This review discusses recent studies in C. elegans that have identified five core proteins required for centriole formation, thus shedding
Gönczy, P, Leidel, Sebastian, Gönczy, Pierre, Leidel, S   +3 more
core   +1 more source

Quantitative Multi-Parametric Evaluation of Centrosome Declustering Drugs: Centrosome Amplification, Mitotic Phenotype, Cell Cycle and Death

, 2014
Unlike normal cells, cancer cells contain amplified centrosomes and rely on centrosome clustering mechanisms to form a pseudobipolar spindle that circumvents potentially fatal spindle multipolarity (MP).
Pannu, Vaishali, Osan, R., Cheng, A., Clewley, Robert, Rida, PCG, Aneja, Ritu, Ogden, Angela   +6 more
core  

Asymmetry in centrosome maturation revealed through AIR-1 dynamics in the early Caenorhabditis elegans embryo

Scientific Reports
Centrosomes are critical organelles associated with the nucleus, consisting of a pair of centrioles surrounded by a cloud of pericentriolar material. They serve as key nucleation sites for microtubule arrays and are essential for positioning the nucleus ...
Shayne M. Plourde, Natalia Kravtsova, Adriana T. Dawes   +2 more
doaj   +1 more source

Golgi and centrosome: building a functional partnership.

, 2010
The mammalian Golgi apparatus is characterized by a ribbon-like organization adjacent to the centrosome during interphase and extensive fragmentation and dispersal away from the centrosome during mitosis.
Colanzi A, Sütterlin C
core  

Centrosome cohesion: functions of C-NAP1

, 2016
Double stranded DNA encodes the genetic material of the cell. Replication and segregation cycles are regulated in order to maintain the integrity of the DNA sequence from one cell cycle to the next.
Flanagan, Anne-Marie
core   +1 more source

Delayed centrosome maturation causes asymmetric particle partitioning.

, 2012
(A) Time series of dynein distribution with ∼1 hr time delay between the centrosome maturation (also see Movie S3). During the simulated duration of 3000 s, the number of microtubules organized by the dominant centrosome increases from 200 to 800.
Jennifer Lippincott-Schwartz (171711), Jian Liu (33711), Jing Chen (4762)   +2 more
core   +1 more source

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science
Centrosome amplification in cancer cells produces excess centrosomes that cluster and decluster throughout the cell cycle, a process critical for tumorigenesis.
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
doaj   +1 more source

Inhibiting centrosome clustering reduces cystogenesis and improves kidney function in autosomal dominant polycystic kidney disease

JCI Insight
Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder accounting for approximately 5% of patients with renal failure, yet therapeutics for the treatment of ADPKD remain limited. ADPKD tissues display abnormalities in the biogenesis
Tao Cheng, Aruljothi Mariappan, Ewa Langner, Kyuhwan Shim, Jay Gopalakrishnan, Moe R. Mahjoub   +5 more
doaj   +1 more source

Centrosome migration and apical membrane formation during epithelial polarization in MDCK cysts. [PDF]

Elife
Wang PK, Lin KH, Tang TK.
europepmc   +1 more source