Results 141 to 150 of about 82,885 (231)

Inhibiting centrosome clustering reduces cystogenesis and improves kidney function in autosomal dominant polycystic kidney disease

JCI Insight
Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder accounting for approximately 5% of patients with renal failure, yet therapeutics for the treatment of ADPKD remain limited. ADPKD tissues display abnormalities in the biogenesis
Tao Cheng, Aruljothi Mariappan, Ewa Langner, Kyuhwan Shim, Jay Gopalakrishnan, Moe R. Mahjoub   +5 more
doaj   +1 more source

A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in g2 phase after dna damage

, 2018
DNA damage can induce centrosome overduplication in a manner that requires G2-to-M checkpoint function, suggesting that genotoxic stress can decouple the centrosome and chromosome cycles. How this happens is unclear. Using live-cell imaging of cells that
Morrison, C. G., Inanc, B., Dodson, H.
core  

The centriculum, a membrane reticulum that surrounds Caenorhabditis elegans centrosomes, might serve as a microtubule filter. [PDF]

J Cell Sci
Maheshwari R, Rahman MM, Ruddick A, Drey S, Mirabello RS, Cohen-Fix O.   +5 more
europepmc   +1 more source

Zika Virus NS3 Drives the Assembly of a Replication Compartment-like Structure That Exerts the Structural and Physiological Functions of the Viral Replication Compartment. [PDF]

Viruses
Sultana T, Zheng C, Jones J, Zamani N, Toledo MP, Morton GM, Wang YJ, Megraw TL.   +7 more
europepmc   +1 more source

Centrosome linker protein CEP68 modulates cellular stress responses via nuclear condensate formation and HSP27 interaction. [PDF]

iScience
Hung HF, Zhu PP, Blackstone C.
europepmc   +1 more source

Oxidative stress and serum deprivation influence the evolution of newly formed tetraploid cells during tumorigenesis. [PDF]

Proc Natl Acad Sci U S A
Sweet ML, Bloomfield M, Keen N, Bano N, Pan X, Baudoin NC, Udayasuryan B, Ahmad RN, Riddervold E, Klaiber E, Verbridge SS, Schmelz EM, Chen J, Cimini D.   +13 more
europepmc   +1 more source

Distinct D-box motifs in SPD-2 mediate APC/CFZR-1-dependent degradation and centrosomal localization in Caenorhabditis elegans embryos. [PDF]

G3 (Bethesda)
Yim RN, DiPanni JR, Rivera PA, Song MH.
europepmc   +1 more source

Centriolar satellites regulate <i>CEP350</i> mRNA stability and centrosome amplification. [PDF]

Mol Biol Cell
Martinez A, Pearson CG.
europepmc   +1 more source

Bora, CEP192 and Cenexin regulate distinct Plk1-dependent cell and centrosome cycle transitions. [PDF]

Nat Commun
Dwivedi D, Borges C, Harry D, Cirillo L, Meraldi P.   +4 more
europepmc   +1 more source

Cdk1-phosphorylated Nur77 accumulates at the centrosome during mitosis to regulate the Cep192-PLK1 signaling axis. [PDF]

Cell Death Dis
Xie G, Wang Q, Du M, Zhou Y, Chen Z, Peng S, Zhou H, Zhang X, Cai Q, Alitongbieke G, Chen X, Yi J, Ye X, Wang H, Ye X, Xu L, Niu B, Wang H, Ke Y, Xu Y, Zhou H, Su Y, Zhang XK.   +22 more
europepmc   +1 more source