Results 141 to 150 of about 77,614 (192)
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Centrosomal and non‐centrosomal microtubules

Biology of the Cell, 1999
While microtubule (MT) arrays in cells are often focused at the centrosome, a variety of cell types contain a substantial number of non‐centrosomal MTs. Epithelial cells, neurons, and muscle cells all contain arrays of non‐centrosomal MTs that are critical for these cells' specialized functions. There are several routes by which non‐centrosomal MTs can
T J, Keating, G G, Borisy
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Aurora A, centrosome structure, and the centrosome cycle

Environmental and Molecular Mutagenesis, 2009
AbstractThe centrosome, also known as the microtubule organizing center of the cell, is a membrane‐less organelle composed of a pair of barrel‐shaped centrioles surrounded by electron‐dense pericentriolar material. The centrosome progresses through the centrosome cycle in step with the cell cycle such that centrosomes are duplicated in time to serve as
Kara B, Lukasiewicz, Wilma L, Lingle
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Centrosomes and Centrosome Equivalents in Other Systems

2022
Stem cells are important to sustain tissue growth during development, to repair damaged tissue after injury, and to maintain homeostasis during adulthood. Precisely programmed stem cell renewal and differentiation is critical, as failure in balance can lead to tumorigenesis as a result of over-proliferation or to degeneration as a result of decline in ...
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Centrosomes in Reproduction

2022
Centrosome functions are vitally important for all aspects of reproduction with essential functions during meiosis, fertilization, cell division, centrosome remodeling during cellular polarization for tissue formation, and all stages of subsequent embryo development.
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The centrosome and parthenogenesis

1999
Publisher Summary This chapter discusses the functional description of the centrosome as well as two main aspects of centrosome reproduction and the parthenogenetic activity of the centrosome: (1) the molecular mechanisms underlying centrosome biogenesis itself and (2) the coordination between the nuclear cycle and the centrosome cycle.
T, Küntziger, M, Bornens
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Centrosomes and cancer

Biology of the Cell, 1999
The centrosome functions as the major microtubule organizing center (MTOC) of the cell and as such it determines the number, polarity, and organization of interphase and mitotic microtubules. Cytoplasmic organization, cell polarity and the equal partition of chromosomes into daughter cells at the time of cell division are all dependent on the normal ...
J L, Salisbury   +3 more
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The Centrosome Cycle

2006
Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and provide a site for concerted regulation of cell cycle progression. While there is diversity in microtubule organizing center structure among eukaryotes, many centrosome components, such as centrin, are ...
Christopher P, Mattison, Mark, Winey
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Centrosome maturation

1999
In the past, centrosome maturation has been described as the change in microtubule nucleation potential that occurs as cells pass through specific phases of the cell cycle. It is suggested that the idea of centrosome maturation be expanded to include gain of functions that are not necessarily related to microtubule nucleation.
R E, Palazzo   +4 more
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Centrosomal TACCtics

BioEssays, 2002
AbstractAlthough the centrosome was first described over 100 years ago, we still know relatively little of the molecular mechanisms responsible for its functions. Recently, members of a novel family of centrosomal proteins have been identified in a wide variety of organisms.
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