Results 151 to 160 of about 77,614 (192)
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Centrosome competition: A possibility?
Experimental Cell Research, 1990A recent theory on the evolution of sexuality, has hypothesized heritable variation in the functional properties of centrosomes, leading to competition for the organization of the mitotic spindle when different centrosomes enter a common cytoplasm.
MARIN G., ARGENTON, FRANCESCO
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Centrosome instability: when good centrosomes go bad
Cellular and Molecular Life Sciences, 2021The centrosome is a tiny cytoplasmic organelle that organizes and constructs massive molecular machines to coordinate diverse cellular processes. Due to its many roles during both interphase and mitosis, maintaining centrosome homeostasis is essential to normal health and development. Centrosome instability, divergence from normal centrosome number and
John M. Ryniawec, Gregory C. Rogers
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Centrosomes and parthenogenesis
2001Publisher Summary This chapter describes the parthenogenetic assay and reviews the results concerning the capacity of centrosomes isolated from different cell types in different species to induce frog egg cleavage. The chapter discusses the potential of current in vitro systems to identify important molecular events of the pathway and also ...
F, Tournier, M, Bornens
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Trends in Cell Biology, 1999
The centriole is a cylinder of nine triplet microtubules found at the core of the centrosome. The location of centrioles within the centrosome has always seemed to suggest a role in centrosome function, but proof of this has remained elusive. In part, this is due to the lack of convenient methods to remove centrioles specifically.
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The centriole is a cylinder of nine triplet microtubules found at the core of the centrosome. The location of centrioles within the centrosome has always seemed to suggest a role in centrosome function, but proof of this has remained elusive. In part, this is due to the lack of convenient methods to remove centrioles specifically.
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Centrosome number is controlled by a centrosome-intrinsic block to reduplication
Nature Cell Biology, 2003The centrosome duplicates once in S phase. To determine whether there is a block in centrosome reduplication, we used a cell fusion assay to compare the duplication potential of unduplicated G1 centrosomes and recently duplicated G2 centrosomes. By fusing cells in different cell cycle stages, we found that G2 centrosomes were unable to reduplicate in a
Connie, Wong, Tim, Stearns
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Centrosome biogenesis and function: centrosomics brings new understanding
Nature Reviews Molecular Cell Biology, 2007Centrosomes, which were first described in the late 19th century, are found in most animal cells and undergo duplication once every cell cycle so that their number remains stable, like the genetic material of a cell. However, their function and regulation have remained elusive and controversial. Only recently has some understanding of these fundamental
Mónica, Bettencourt-Dias +1 more
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Centrosomes and The Cell Cycle
Journal of Cell Science, 1989ABSTRACT Centrosomes are the ensemble of organelles that form the poles of the mitotic spindle. We have examined the properties of the mechanisms that control the precise doubling, or reproduction, of centrosomes during the cell cycle. A functional analysis of this event in sea urchin eggs indicates that it is limited by the reproduction
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Computational centrosomics: An approach to understand the dynamic behaviour of centrosome
Gene, 2012Centrosomes are the key regulating element of cell cycle progression. Aberrations in their functional mechanism leads to several cancer related disorders. Although genomic studies in the field of centrosome have been extensively carried out, with the lack of structural conformation, the proteomic analysis of pathological genetic mutation is still a ...
Ambuj, Kumar, Rituraj, Purohit
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Centrosome reproduction in Vitro: Mammalian centrosomes in Xenopus lysates
2001Publisher Summary This chapter discusses reproduction of centrosomes in vitro . The structural complexity of the animal centrosome, particularly the presence of the centriole pair as a conspicuous feature, suggests that a specific study of the animal centrosome is needed.
M, Piel, M, Bornens
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