Results 111 to 120 of about 83,543 (230)
Centrosome proteins: a major class of autoantigens in scleroderma
, 2008 Autoantibodies to intracellular antigens are a hallmark of autoimmune diseases, although their role in disease pathogenesis is unclear. Centrosomes are organelles involved in the organization of the mitotic spindle and they are targets of autoantibodies ...
Vazquez-Abad, Dolores +4 more
core +1 more source
Centrosome amplification and cancer: A question of sufficiency. [PDF]
, 2017 Centrosome amplification is a common feature of many types of cancer, but whether it is a cause or consequence is hotly debated. In this issue of Developmental Cell, Levine et al. (2017) provide strong evidence that centrosome amplification is sufficient
Basto, Renata +5 more
core +1 more source
Cell Division, 2019 Background At the onset of mitosis, the centrosome expands and matures, acquiring enhanced activities for microtubule nucleation and assembly of a functional bipolar mitotic spindle.
Chieh-Ting Fang +3 more
doaj +1 more source
CP91 is a component of the Dictyostelium centrosome involved in centrosome biogenesis
European Journal of Cell Biology, 2016 The Dictyostelium centrosome is a model for acentriolar centrosomes and it consists of a three-layered core structure surrounded by a corona harboring microtubule nucleation complexes. Its core structure duplicates once per cell cycle at the G2/M transition.
Putzler, Sascha +2 more
openaire +2 more sources
African swine fever virus infection disrupts centrosome assembly and function
, 2005 African swine fever virus (ASFV) is a large, enveloped DNA virus that assembles in perinuclear sites located close to the centrosome. It is reported here that the microtubule network becomes disorganized soon after the onset of viral DNA replication and ...
Jouvenet, Nolween +3 more
core +1 more source
Identification of S6K2 as a centrosome-located kinase.
, 2007 Ribosomal S6 kinase 2 (S6K2) acts downstream of the mammalian target of rapamycin (mTOR). Here, we show that some S6K2 localize at the centrosome throughout the cell cycle. S6K2 is found in the pericentriolar area of the centrosome.
Montecucco A +5 more
core +1 more source
The centrosome rather follows than leads the nucleus during nuclear oscillations.
, 2014 (A) Centrosome positions relative to the center of the nucleus along the movement axis/vector determined by the nucleus. The centrosome is mostly behind. (B) Maximal speed of the nucleus as a function of the relative position of the centrosome.
Ulrike Kutay (239036) +4 more
core +1 more source
The LINC complex ensures accurate centrosome positioning during prophase
Life Science AllianceCentrosome positioning in prophase is essential for efficient spindle assembly. Here, we show that centrosome positioning requires LINC complex–mediated loading of dynein on the nuclear envelope.
Joana T Lima +2 more
doaj +1 more source
Hypoxia-Induced Centrosome Loss in Epithelial Cells
, 2022 Centrosome loss has recently been reported as a phenotype of prostate cancer. Hypoxia, an environmental condition seen commonly in prostate cancer, can cause centrosome loss in the immortalized prostate epithelial cell line, RWPE1.
Loertscher, Emily
core +1 more source
, 2018 An inherent asymmetry exists between the two centrosomes of a dividing cell. One centrosome is structurally more mature (mother centrosome) than the other (daughter centrosome).
Ramanan, Narendrakumar +7 more
core +1 more source