Results 51 to 60 of about 82,885 (231)
Proteins implicated in muscular dystrophy and cancer are functional constituents of the centrosome
Life Science Alliance, 2022 This study demonstrates that the muscular dystrophy-associated proteins dystrophin, utrophin, dysferlin, and calpain-3 localize to the centrosome and that their absence leads to excess centrosomes, compromised nuclear morphology, impaired centrosome ...
Lilli Winter +5 more
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Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]
, 2009 Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Thomas H. Giddings +9 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2020 Mammalian haploid somatic cells are unstable and prone to diploidize, but the cause of haploid instability remains largely unknown. Previously, we found that mammalian haploid somatic cells suffer chronic centrosome loss stemming from the uncoupling of ...
Koya Yoshizawa +3 more
doaj +1 more source
Centrosome Defects in Hematological Malignancies: Molecular Mechanisms and Therapeutic Insights
Blood Science, 2022 Defects in centrosomes are associated with a broad spectrum of hematological malignancies, such as leukemia and lymphoma. Centrosomes in these malignancies display both numerical and structural aberrations, including alterations in the number and size of
Mingzheng Hu, Yijie Wang, Jun Zhou
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Cep164, a novel centriole appendage protein required for primary cilium formation [PDF]
, 2007 Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and ...
Graser, Susanne +20 more
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The dynamics of centrosome assembly in the early Drosophila embryo [PDF]
, 2021 Centrosomes are important for many cellular processes. They comprise of a pair of centrioles surrounded by an amorphous pericentriolar material (PCM).
Wong, Siu Shing
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A Proximity Mapping Journey into the Biology of the Mammalian Centrosome/Cilium Complex
Cells, 2020 The mammalian centrosome/cilium complex is composed of the centrosome, the primary cilium and the centriolar satellites, which together regulate cell polarity, signaling, proliferation and motility in cells and thereby development and homeostasis in ...
Melis Dilara Arslanhan +2 more
doaj +1 more source
Scientific Reports, 2023 Alterations in centrosome proteins may result in centrosome abnormalities such as disorganized spindles and centrosome amplification, leading to aneuploidy and genomic instability.
Laxmidhar Das
doaj +1 more source
, 2020 Cancer initiation and progression are multistep processes that rely on the generation and accumulation of non-lethal mutations, which deregulate function of tumor suppressor genes and activate oncogenic pathways.
Mittal, Karuna
core +1 more source