Results 51 to 60 of about 72,372 (185)

Dual roles of CCDC102A in governing centrosome duplication and cohesion

Cell Reports
Summary: In animal cells, the dysregulation of centrosome duplication and cohesion maintenance leads to abnormal spindle assembly and chromosomal instability, contributing to developmental disorders and tumorigenesis.
Tianning Wang, Guiliang Fan, Yuqing Xia, Yuhong Zou, Yunjie Liu, Jiaxin Wang, Yingchun Hu, Junlin Teng, Ning Huang, Jianguo Chen   +9 more
doaj   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Catalytic growth in a shared enzyme pool ensures robust control of centrosome size

eLife
Accurate regulation of centrosome size is essential for ensuring error-free cell division, and dysregulation of centrosome size has been linked to various pathologies, including developmental defects and cancer.
Deb Sankar Banerjee, Shiladitya Banerjee
doaj   +1 more source

The G₁ phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification

Cell Division, 2011
Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis.
Saavedra Harold I, Adon Arsene M, Harrison Mary K   +2 more
doaj   +1 more source

LIM kinase1 regulates mitotic centrosome integrity via its activity on dynein light intermediate chains [PDF]

Open Biology, 2018
Abnormal centrosome number and function have been implicated in tumour development. LIM kinase1 (LIMK1), a regulator of actin cytoskeleton dynamics, is found to localize at the mitotic centrosome. However, its role at the centrosome is not fully explored.
Sirong Ou, Mei-Hua Tan, Ting Weng, HoiYeung Li, Cheng-Gee Koh   +4 more
doaj   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Excessive centrosome abnormalities without ongoing numerical chromosome instability in a Burkitt's lymphoma

Molecular Cancer, 2003
Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and chromosomal instability.
Cin Paola, Lee Benjamin H, Duensing Stefan, Münger Karl   +3 more
doaj   +1 more source

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, EarlyView.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source

CCDC102B functions in centrosome linker assembly and centrosome cohesion [PDF]

Journal of Cell Science, 2018
ABSTRACT The proteinaceous centrosome linker is an important structure that allows the centrosome to function as a single microtubule-organizing center (MTOC) in interphase cells. However, the assembly mechanism of the centrosome linker components remains largely unknown.
Yuqing Xia, Ning Huang, Zhiquan Chen, Fangyuan Li, Guiliang Fan, Dandan Ma, Jianguo Chen, Junlin Teng   +7 more
openaire   +2 more sources

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source