Results 51 to 60 of about 77,614 (192)
Hematological Oncology, Volume 44, Issue 4, July 2026.ABSTRACT Chronic lymphocytic leukemia (CLL) is a clinically and molecularly heterogeneous disease. PKMYT1, a G2/M cell cycle kinase, has been implicated in tumor progression in several cancers, but its role in CLL remains unclear. We evaluated PKMYT1 expression in primary CLL samples and analyzed associations with cytogenetic features and clinical ...
Elizabete Cristina Iseke Bispo +6 more
wiley +1 more source
Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.ABSTRACT Giardia lamblia, a protozoan parasite that causes diarrhea in humans, contains two centrins implicated in cellular morphology and cell division. To identify proteins interacting with each G. lamblia centrin (GlCent), we performed a yeast two‐hybrid assay.
Mee Young Shin +2 more
wiley +1 more source
Effect of p21Waf1 and p27Kip1 on centrosome replication and proliferation of breast cancer cell
, 2010 Aberrant centrosome numbers are detected in virtually all cancers，increasing the risk for cell division errors and chromosomal instability.
Yin-Lin Ge +5 more
core
PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics
, 2023 The centrosome is a dynamic structure that undergoes structural and functional transitions, which are coordinated with the cell cycle. It functions as the microtubule organizing center (MTOC) in interphase, duplicates and separates in S-G 2 forms the ...
NC DOCKS at East Carolina University +1 more
core
INF2 promotes the formation of detyrosinated microtubules necessary for centrosome reorientation in T cells [PDF]
, 2012 T cell antigen receptor-proximal signaling components, Rho-family GTPases, and formin proteins DIA1 and FMNL1 have been implicated in centrosome reorientation to the immunological synapse of T lymphocytes.
Correas Hornero, María Isabel +18 more
core +1 more source
A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley +1 more source
, 2014 Chromosomal translocations observed in myeloproliferative neoplasms (MPNs) frequently fuse genes that encode centrosome proteins and tyrosine kinases. This causes constitutive activation of the kinase resulting in aberrant, proliferative signaling.
Wan-Jen Hong +7 more
core +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, Volume 16, Issue 6, Page 1213-1221, June 2026.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 6, Page 1222-1236, June 2026.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source