Results 11 to 20 of about 98,093 (226)
The Dictyostelium Centrosome [PDF]
Cells, 2021 The centrosome of Dictyostelium amoebae contains no centrioles and consists of a cylindrical layered core structure surrounded by a corona harboring microtubule-nucleating γ-tubulin complexes. It is the major centrosomal model beyond animals and yeasts.
Ralph Gräf +4 more
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Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes
Cell Structure and Function, 2020 Centrosomes are highly conserved organelles that act as the major microtubule-organizing center (MTOC) in animal somatic cells. Through their MTOC activity, centrosomes play various roles throughout the cell cycle, such as supporting cell migration in interphase and spindle organization and positioning in mitosis.
Takeda, Yutaka +3 more
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Centrosome Biology: Polymer-Based Centrosome Maturation [PDF]
Current Biology, 2017 The molecular mechanisms that control how the centrosome increases in size and microtubule nucleation capacity during mitosis have remained elusive. Recent work using in vitro assays provide exciting clues as to how this may occur.
Gagan D, Gupta, Laurence, Pelletier
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Centrosome-Associated NDR Kinase Regulates Centrosome Duplication [PDF]
Molecular Cell, 2007 Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression
Hergovich, Alexander +3 more
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Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]
, 1996 In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M. +3 more
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The phosphorylation of PHF5A by TrkA-ERK1/2-ABL1 cascade regulates centrosome separation
Cell Death and Disease, 2023 During interphase, the newly duplicated pairs of centrosomes are held together by a centrosome linker, and the centrosome separation needs the disruption of this linker to induce the duplicated centrosomes separating into two distinct microtubule ...
Chen Song +10 more
doaj +1 more source
The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis [PDF]
, 2015 Acknowledgements We wish to thank Jorge Galán, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical ...
A Batista +51 more
core +1 more source
Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole
Nature Communications, 2016 Newly formed centrioles mature into functional mother centrioles. Here the authors show that the scaffolding protein Cep295 is recruited to the procentriole assembly site and assists daughter centriole assembly and daughter-to-mother centriole conversion.
Yuki Tsuchiya +4 more
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Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number
Cell Reports, 2018 Summary: The number of centrioles is tightly controlled to ensure bipolar spindle assembly, which is a prerequisite to maintain genome integrity. However, our understanding of the fundamental principle that governs the formation of a single procentriole ...
Midori Ohta +6 more
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Emerging roles of centrosome cohesion
Open Biology, 2022 The centrosome, consisting of centrioles and the associated pericentriolar material, is the main microtubule-organizing centre (MTOC) in animal cells.
Hairuo Dang, Elmar Schiebel
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