Results 11 to 20 of about 77,614 (192)

The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion [PDF]

, 2000
Duplicating centrosomes are paired during interphase, but are separated at the onset of mitosis. Although the mechanisms controlling centrosome cohesion and separation are important for centrosome function throughout the cell cycle, they remain poorly ...
Fry, A. M., Erich A. Nigg, Andrew M. Fry, Stierhof, Y. D., Mayor, T., York-Dieter Stierhof, Tanaka, K., Nigg, E. A., Thibault Mayor, Kayoko Tanaka   +9 more
core   +1 more source

Centrosome Biology: The Ins and Outs of Centrosome Assembly [PDF]

Current Biology, 2015
As a microtubule-organizing center, the centrosome undergoes a dramatic increase in size - via expansion of the pericentriolar material - during mitosis. Recent work reveals shared assembly properties of a protein scaffold that facilitates and supports this expansion, a process critical to spindle assembly.
Prosser, Suzanna L., Pelletier, Laurence   +1 more
openaire   +2 more sources

Centrosome Biology: Polymer-Based Centrosome Maturation [PDF]

Current Biology, 2017
The molecular mechanisms that control how the centrosome increases in size and microtubule nucleation capacity during mitosis have remained elusive. Recent work using in vitro assays provide exciting clues as to how this may occur.
Gagan D, Gupta, Laurence, Pelletier
openaire   +2 more sources

Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly [PDF]

, 2009
In animal somatic cells, bipolar spindle formation requires separation of the centrosome-based spindle poles. Centrosome separation relies on multiple pathways, including cortical forces and antiparallel microtubule (MT) sliding, which are two activities
Winter, Jennifer R., Toso, Alberto, Ainslie J. Garrod, Garrod, Ainslie J., Alberto Toso, Jennifer R. Winter, Ana C. Amaro, Patrick Meraldi, Amaro, Ana C., McAinsh, Andrew D., Meraldi, Patrick, Andrew D. McAinsh   +11 more
core   +1 more source

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 [PDF]

, 1998
Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans.
Fry, A. M., Erich A. Nigg, Stierhof, Y. D., Mayor, T., Y. D. Stierhof (7653686), Tanaka, K., Nigg, E. A., Meraldi, P., Thibault Mayor, A. M. Fry (7651490), E. A. Nigg (7651493), Kayoko Tanaka, Andrew M. Fry, P. Meraldi (7653683), K. Tanaka (1500880), Patrick Meraldi, York-Dieter Stierhof, T. Mayor (7653680)   +17 more
core   +1 more source

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]

, 2012
Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Stangherlin, A, Surdo, N. C., Terrin, A., Sawa, A., Terrin, A, N. E. Jordanides, A. Stangherlin, Monterisi, S, Mountford, JC, Monterisi, S., A. Terrin, Surdo, NC, Stefania Monterisi, Akira Sawa, Mongillo, M, Jordanides, NE, Alessandra Stangherlin, Koschinski, A, Manuela Zaccolo, Joanne C. Mountford, Nicoletta C. Surdo, Niove E. Jordanides, Jordanides, N..E., Anna Zoccarato, Koschinski, A., Zaccolo, Manuela, MONGILLO, MARCO, Andreas Koschinski, Anna Terrin, M. Zaccolo, Sawa, A, A. Koschinski, A. Zoccarato, Zoccarato, A., Zaccolo, M., A. Sawa, Mountford, J.C., Zoccarato, A, N. C. Surdo, Marco Mongillo, Stangherlin, A., Mongillo, M., S. Monterisi, J. C. Mountford   +43 more
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Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]

, 2011
Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Robert A. Cross, Kaseda, Kuniyoshi, Cross, R. A., Kuniyoshi Kaseda, McAinsh, Andrew D., Andrew D. McAinsh   +5 more
core   +1 more source

Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates [PDF]

, 2012
Protein kinases are important regulators of signal transduction pathways in both unicellular and multicellular organisms. They play critical roles in biological processes such as cell growth, division, differentiation, adhesion, motility and cell death ...
Kohler, Reto
core   +1 more source

Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]

, 2009
Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Thomas H. Giddings, Mark Winey, Osborn, DP, Chad G. Pearson, Philip L. Beales, Beales, PL, Giddings, TH, Winey, M, Pearson, CG, Daniel P.S. Osborn   +9 more
core   +1 more source

Cep164, a novel centriole appendage protein required for primary cilium formation [PDF]

, 2007
Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and ...
Graser, Susanne, Erich A. Nigg, Gassner, Oliver S., Gassner, O. S., Susanne Graser, Stierhof, Y. D., Lavoie, S. B., Stierhof, York-Dieter, Nigg, E. A., Sébastien B. Lavoie, Le Clech, M., Stefan Lamla, Graser, S., Nigg, Erich A., Lavoie, Sébastien B., York-Dieter Stierhof, Le Clech, Mikael, Oliver S. Gassner, Mikael Le Clech, Lamla, S., Lamla, Stefan   +20 more
core   +1 more source