Results 11 to 20 of about 72,372 (185)

The Dictyostelium Centrosome [PDF]

Cells, 2021
The centrosome of Dictyostelium amoebae contains no centrioles and consists of a cylindrical layered core structure surrounded by a corona harboring microtubule-nucleating γ-tubulin complexes. It is the major centrosomal model beyond animals and yeasts.
Ralph Gräf, Marianne Grafe, Irene Meyer, Kristina Mitic, Valentin Pitzen   +4 more
openaire   +3 more sources

Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes

Cell Structure and Function, 2020
Centrosomes are highly conserved organelles that act as the major microtubule-organizing center (MTOC) in animal somatic cells. Through their MTOC activity, centrosomes play various roles throughout the cell cycle, such as supporting cell migration in interphase and spindle organization and positioning in mitosis.
Takeda, Yutaka, Kuroki, Kanako, Chinen, Takumi, Kitagawa, Daiju   +3 more
openaire   +3 more sources

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies. [PDF]

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Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Frisby D, Misri G, Naslavsky N, Caplan S.   +3 more
europepmc   +2 more sources

The phosphorylation of PHF5A by TrkA-ERK1/2-ABL1 cascade regulates centrosome separation

Cell Death and Disease, 2023
During interphase, the newly duplicated pairs of centrosomes are held together by a centrosome linker, and the centrosome separation needs the disruption of this linker to induce the duplicated centrosomes separating into two distinct microtubule ...
Chen Song, Yu Zhang, Yutong Li, Juntao Bie, Zhe Wang, Xin Yang, Haishuang Li, Liangyi Zhu, Tianzhuo Zhang, Qing Chang, Jianyuan Luo   +10 more
doaj   +1 more source

Emerging roles of centrosome cohesion

Open Biology, 2022
The centrosome, consisting of centrioles and the associated pericentriolar material, is the main microtubule-organizing centre (MTOC) in animal cells.
Hairuo Dang, Elmar Schiebel
doaj   +1 more source

Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole

Nature Communications, 2016
Newly formed centrioles mature into functional mother centrioles. Here the authors show that the scaffolding protein Cep295 is recruited to the procentriole assembly site and assists daughter centriole assembly and daughter-to-mother centriole conversion.
Yuki Tsuchiya, Satoko Yoshiba, Akshari Gupta, Koki Watanabe, Daiju Kitagawa   +4 more
doaj   +1 more source

Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number

Cell Reports, 2018
Summary: The number of centrioles is tightly controlled to ensure bipolar spindle assembly, which is a prerequisite to maintain genome integrity. However, our understanding of the fundamental principle that governs the formation of a single procentriole ...
Midori Ohta, Koki Watanabe, Tomoko Ashikawa, Yuka Nozaki, Satoko Yoshiba, Akatsuki Kimura, Daiju Kitagawa   +6 more
doaj   +1 more source

Centrosome Biology: The Ins and Outs of Centrosome Assembly [PDF]

Current Biology, 2015
As a microtubule-organizing center, the centrosome undergoes a dramatic increase in size - via expansion of the pericentriolar material - during mitosis. Recent work reveals shared assembly properties of a protein scaffold that facilitates and supports this expansion, a process critical to spindle assembly.
Prosser, Suzanna L., Pelletier, Laurence   +1 more
openaire   +2 more sources

The Cep57-pericentrin module organizes PCM expansion and centriole engagement

Nature Communications, 2019
Centriole disengagement occurs towards mitotic exit and involves cleavage of pericentrin, a component of the pericentriolar material. Here the authors show that depletion of the centrosomal protein Cep57 leads to precocious centriole disengagement, and ...
Koki Watanabe, Daisuke Takao, Kei K Ito, Mikiko Takahashi, Daiju Kitagawa   +4 more
doaj   +1 more source

Centrosome Biology: Polymer-Based Centrosome Maturation [PDF]

Current Biology, 2017
The molecular mechanisms that control how the centrosome increases in size and microtubule nucleation capacity during mitosis have remained elusive. Recent work using in vitro assays provide exciting clues as to how this may occur.
Gagan D, Gupta, Laurence, Pelletier
openaire   +2 more sources