Results 51 to 60 of about 12,764 (170)

Cyclin-dependent kinase control of motile ciliogenesis [PDF]

, 2018
Cycling cells maintain centriole number at precisely two per cell in part by limiting their duplication to S phase under the control of the cell cycle machinery.
Axelrod, Jeffrey D., Salazar-De Simone, Glicella, Vladar, Eszter K., Stratton, Miranda B., Stearns, Tim, Wolgemuth, Debra J., Saal, Maxwell L., Wang, Xiangyuan   +7 more
core   +1 more source

Expanding the Phenotypic Spectrum of TXNDC15‐Related Ciliopathies to Include Joubert Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic loss‐of‐function variants in TXNDC15 are a known cause of the perinatally lethal ciliopathy Meckel syndrome (MKS). TXNDC15 encodes an endoplasmic reticulum (ER)‐resident thioredoxin‐domain protein required for ciliary transition zone integrity.
Zachary T. Sentell, Robert Geraghty, Juliana E. Arcila‐Galvis, Praveen Dhondurao‐Sudhindar, Sergio Foullerat Cañada, Fulvio D'Abrusco, Bosanka Jocic‐Jakubi, Miguel Barroso‐Gil, Valentina Serpieri, Thomas M. Kitzler, Kate E. Chandler, Eleanor G. Seaby, Gabrielle Wheway, Jennifer C. Dempsey, Dan Doherty, Enza M. Valente, John A. Sayer   +16 more
wiley   +1 more source

Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking

, 2018
Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly ...
Joon Kim, Jongshin Kim, Jin Man Kim, Hyowon Hong, June-Koo Lee, Haiin Jo, Won Do Heo, Min Hwan Kim   +7 more
core   +1 more source

A ciliopathy complex builds distal appendages to initiate ciliogenesis [PDF]

, 2021
Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium. Using proteomics and superresolved imaging, we identify a module that we term DISCO (distal centriole complex).
Jeremy F. Reiter, García Verdugo, José Manuel, Herranz Pérez, Vicente, Westlake, Christopher, Erica Stevenson, Shi, Xiaoyu, Herranz-Pérez, Vicente, Addison Rains, Kumar, Dhivya, Yoder, Bradley K., Bradley K. Yoder, Qualong, Lu, Quanlong Lu, Lü, Quanlong, Swaney, Danielle L., Krogan, Nevan, García-Verdugo, Jose Manuel, Swaney, Danielle, Xiaoyu, Shi, Jose Manuel Garcia-Verdugo, Nevan J. Krogan, Reiter, Jeremy, Dhivya Kumar, Vicente Herranz-Pérez, Danielle L. Swaney, Yoder, Bradley, Bo Huang, Rains, Addison, Krogan, Nevan J., Huang, Bo, Stevenson, Erika, Christopher Westlake, Reiter, Jeremy F., Xiaoyu Shi, Stevenson, Erica, Swaney, Danielle L, Reiter, Jeremy F, Yoder, Bradley K, Krogan, Nevan J   +38 more
core   +1 more source

Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis

Cells, 2015
Centrosomes are major microtubule-organizing centers of animal cells that consist of two centrioles. In mitotic cells, centrosomes are duplicated to serve as the poles of the mitotic spindle, while in quiescent cells, centrosomes move to the apical ...
Shubhra Majumder, Ayla Cash, Harold A. Fisk   +2 more
doaj   +1 more source

Microtubule Destabilizing Kinesins: A Historical Perspective and Thoughts for the Future

Cytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton plays critical roles in multiple cellular processes such as mitotic spindle assembly and chromosome segregation. Cells contain a number of microtubule‐associated proteins that regulate microtubule dynamics both temporally and spatially in cells. The microtubule depolymerizing kinesins include members of the Kinesin‐
Claire E. Walczak
wiley   +1 more source

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
Wann, AK, Wann, Angus K.T., Chapple, JP, Knight, MM, Knight, Martin M., Thompson, CL, Thompson, Clare L., Chapple, J. Paul   +7 more
core   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

Lamin A-mediated nuclear lamina integrity is required for proper ciliogenesis

, 2020
[[abstract]]The primary cilium is a sensory organelle that receives specific signals from the extracellular environment important for vertebrate development and tissue homeostasis.
Fan, JR;You, LR;Wang, WJ;Huang, WS;Chu, CT;Chi, YH;Chen, HC
core   +1 more source

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source