Results 51 to 60 of about 11,577 (216)
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport [PDF]
, 2014 Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that regulate cilium formation remain incompletely understood. Here we report that prostaglandin signalling
Li, W. +35 more
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BCAP is a centriolar satellite protein and inhibitor of ciliogenesis [PDF]
, 2017 The centrosome and cilium are organelles with important roles in microtubule organisation, cell division, cell signalling, embryogenesis, and tissue homeostasis. The two organelles are mutually exclusive.
Murdoch, Jennifer +7 more
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Renal FailureThe primary cilium is an organelle found on different cell types in many organs, and is important for human health including the kidney. Diseases due to abnormal or absent cilia are termed ciliopathies and ADPKD is one of the most common ciliopathies and the fourth leading cause of ESKD.
Brennan Winkler +2 more
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Essential role of Cenexin1, but not Odf2, in ciliogenesis [PDF]
Cell Cycle, 2013 Primary cilia are microtubule-based solitary sensing structures on the cell surface that play crucial roles in cell signaling and development. Abnormal ciliary function leads to various human genetic disorders, collectively known as ciliopathies.
Jaerak, Chang +10 more
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Changes in the cell shape and actin organization accompanying primary ciliogenesis in Xenopus epithelial cells [PDF]
, 2019 application/pdfXenopus epithelial A6 cells produce primary cilia most readily when the confluent culture is serumdeprived, in contrast with various mammalian epithelial cells, which usually produce cilia in confluent cultures without serum starvation ...
Ishigami, Riho, Kato-Minoura, Takako
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Coordination of Rab8 and Rab11 in primary ciliogenesis [PDF]
Proceedings of the National Academy of Sciences, 2010 Primary cilia are microtubule-based membrane projections located at the surface of many cells. Defects in primary cilia formation have been implicated in a number of genetic disorders, such as Bardet-Biedl Syndrome and Polycystic Kidney Disease.
Andreas, Knödler +6 more
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Frontiers in Cell and Developmental Biology, 2022 Primary cilia have essential roles as signaling centers during development and adult homeostasis. Disruption of ciliary structure or function causes congenital human disorders called ciliopathies.
Hankyu Lee +12 more
doaj +1 more source
A Kinesin in Command of Primary Ciliogenesis [PDF]
Cell, 2011 Primary cilia sense extracellular cues and in response transmit signals required for development and tissue homeostasis. A new study by Kobayashi et al. (2011) reports that the kinesin Kif24 controls the formation of primary cilia by restricting the nucleation of cilia at centrioles.
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Functional interaction between autophagy and ciliogenesis [PDF]
Nature, 2013 Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia. The recently discovered role of primary cilia in nutrient sensing and signalling motivated us to explore the possible functional interactions between this signalling hub and autophagy.
Pampliega, Olatz +9 more
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Structure of the ciliogenesis-associated CPLANE complex
Science Advances, 2022 Dysfunctional cilia cause pleiotropic human diseases termed ciliopathies. These hereditary maladies are often caused by defects in cilia assembly, a complex event that is regulated by the ciliogenesis and planar polarity effector (CPLANE) proteins Wdpcp, Inturned, and Fuzzy.
Gerasimos Langousis +5 more
openaire +3 more sources