Results 71 to 80 of about 11,577 (216)

Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis

Cells, 2015
Centrosomes are major microtubule-organizing centers of animal cells that consist of two centrioles. In mitotic cells, centrosomes are duplicated to serve as the poles of the mitotic spindle, while in quiescent cells, centrosomes move to the apical ...
Shubhra Majumder, Ayla Cash, Harold A. Fisk   +2 more
doaj   +1 more source

Identification of Novel Interacting Proteins of FUZ and GPR161

PROTEOMICS, EarlyView.
ABSTRACT Protein–protein interactions are central to the dynamic regulation of signaling pathways and provide critical insight into the cellular mechanisms underlying human disease. Our previous study demonstrated biochemical and genetic interactions between FUZ and GPR161 in sonic hedgehog signaling during spinal neural tube development. In this study,
Gabriella Salazar, Anna Battenhouse, Andrew J. Kim, Sung‐Eun Kim   +3 more
wiley   +1 more source

Supplementary Data from Inhibition of Ciliogenesis Promotes Hedgehog Signaling, Tumorigenesis, and Metastasis in Breast Cancer [PDF]

, 2017
Fig. 81. Inhibition of ciliogenesis is not sufficient to initiate mammary tumorigenesis. Fig. 82. Inhibition of ciliogenesis in lft20fl/fi/PyMT +glands. Fig. S3 Inhibition of ciliogenesis does not result in increased frequency of pre-malignant lesions in
Kimberly M. McDermott (14878041), Denise Roe (8522586), Thomas Bunch (6856640), Martha Nunez (15081652), Colleen Fordyce (15081655), Nadia B. Hassounah (8131959), Ray Nagle (429200)   +6 more
core   +1 more source

A Molecular Dissection of Ciliogenesis

The FASEB Journal, 2006
Cilia are known to be crucial for many developmental and physiological processes, yet cilia biogenesis and maintenance are not well understood. In particular, apart from intraflagellar transport proteins, molecular players in the process of ciliogenesis are largely unknown. Two recent studies utilizing the unicellular green alga
Elisa Sandoval Kannegaard, Wallace F. Marshall   +1 more
openaire   +1 more source

Mechanisms of ciliogenesis suppression in dividing cells [PDF]

Cellular and Molecular Life Sciences, 2016
The primary cilium is a non-motile and microtubule-enriched protrusion ensheathed by plasma membrane. Primary cilia function as mechano/chemosensors and signaling hubs and their disorders predispose to a wide spectrum of human diseases. Most types of cells assemble their primary cilia in response to cellular quiescence, whereas they start to retract ...
Goto, Hidemasa, Inaba, Hironori, Inagaki, Masaki   +2 more
openaire   +2 more sources

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source

MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling [PDF]

, 2010
SummaryThe primary cilium is critical for transducing Sonic hedgehog (Shh) signaling, but the mechanisms of its transient assembly are poorly understood.
Bershteyn, Marina, Woo, Wei-Meng, Oro, Anthony E., Marina Bershteyn, Scott X. Atwood, Li, Mischa, Wei-Meng Woo, Mischa Li, Anthony E. Oro, Atwood, Scott X.   +9 more
core   +1 more source

Ouabain modulates ciliogenesis in epithelial cells [PDF]

Proceedings of the National Academy of Sciences, 2011
The exchange of substances between higher organisms and the environment occurs across transporting epithelia whose basic features are tight junctions (TJs) that seal the intercellular space, and polarity, which enables cells to transport substances vectorially.
Isabel, Larre, Aida, Castillo, Catalina, Flores-Maldonado, Ruben G, Contreras, Ivan, Galvan, Jesus, Muñoz-Estrada, Marcelino, Cereijido   +6 more
openaire   +2 more sources

Oleic and linoleic acids induce oxidative stress in chondrocytes by inhibiting autophagy‐regulated ciliogenesis

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The lack of a cure for osteoarthritis (OA), a prevalent joint disease among older individuals, remains an ongoing challenge. Obesity is a common risk factor for OA. Chondrocyte autophagy plays a crucial role in delaying the onset of OA.
Xiaodong Li, Chuanyuan Mao, Guantong Sun, Chen Zhao, Jingjing Dai, Fei Yang, Lei Wang, Xiaoqing Wang   +7 more
doaj   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source