Results 71 to 80 of about 9,240 (177)

ELECTRON MICROSCOPICAL OBSERVATIONS ON THE TRACHEAL EPITHELIUM OF THE ONE-HUMPED CAMEL (CAMELUS DROMEDARIUS) WITH SPECIAL REFERENCE TO CILIOGENESIS [PDF]

open access: yesAssiut Veterinary Medical Journal, 1999
This study was carried out on 10 adult, apparently healthy one-humped camels of different ages and of both sexes. The ultrastructure of camel tracheal epithelium was studied by scanning and transmission electron microscopes.
Yousria A. Abd El-Rahman
doaj   +1 more source

Addressing the Challenges of Translating LRRK2 Biology into Disease‐Modifying Therapies: The LRRK2 Investigative Therapeutics Exchange Initiative

open access: yes
Movement Disorders, EarlyView.
Esther Sammler   +12 more
wiley   +1 more source

Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy

open access: yesCells, 2020
Ciliopathies are a group of human genetic disorders associated with mutations that give rise to the dysfunction of primary cilia. Ciliogenesis-associated kinase 1 (CILK1), formerly known as intestinal cell kinase (ICK), is a conserved serine and ...
Eric J. Wang   +3 more
doaj   +1 more source

Centriolar Protein POC5 Regulates Human Adipogenesis and Cellular Senescence: Insights From a Novel Metabolic Ciliopathy

open access: yesThe FASEB Journal, Volume 40, Issue 14, 31 July 2026.
The identification of a patient carrying a novel homozygous p.(Gln206Ter) POC5 variant revealed a metabolic phenotype associated with POC5 deficiency. POC5 deficiency disrupts centriolar architecture and ciliary organization, leading to impaired proliferation, premature cellular senescence, and reduced insulin signaling.
Valeria Pistorio   +10 more
wiley   +1 more source

The role of SDCCAG3 in ciliogenesis

open access: yes, 2022
Endosomal trafficking is an important process for multiple cell function. The serologically defined colon cancer antigen-3 (SDCCAG3) is a novel endosomal protein localized at early and recycling endosomes. However, its detail function is not well-known. In this thesis, I investigated the role of SDCCAG3 in ciliogenesis and Fas-mediated apoptosis.
openaire   +2 more sources

Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis

open access: yeseLife, 2016
Upon cell cycle exit, centriole-to-basal body transition facilitates cilia formation. The centriolar protein Cp110 is a regulator of this process and cilia inhibitor, but its positive roles in ciliogenesis remain poorly understood.
Peter Walentek   +5 more
doaj   +1 more source

Smoking‐Related Clinical and Molecular Abnormalities in Idiopathic Pulmonary Fibrosis—Associated Pulmonary Hypertension

open access: yesPulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Pulmonary hypertension (PH) is a frequent complication of interstitial lung diseases (ILD) that worsens morbidity and mortality. Cigarette smoking has a detrimental effect on transplant‐free survival of patients with ILD, including patients with idiopathic pulmonary fibrosis (IPF).
Iryna Zhyvylo   +7 more
wiley   +1 more source

M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole

open access: yesNature Communications, 2018
Ciliogenesis is negatively regulated by the CP110-CEP97 complex, although the mechanism controlling mother centriole localization is poorly understood. Here, Huang et al.
Ning Huang   +6 more
doaj   +1 more source

Suppression of Ciliogenesis Alleviates Cellular Senescence via AKT Signaling in Gingival Aging

open access: yesAging Cell, Volume 25, Issue 7, July 2026.
In human gingival aging, aged gingival fibroblasts show increased senescence with enhanced primary cilia formation. Targeting cilia formation by knocking down IFT88 could reverse fibroblast senescence via the AKT signaling and alleviate periodontal inflammation.
Wenjun Shao   +9 more
wiley   +1 more source

In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations

open access: yesCell Reports, 2017
Mutations in CEP290, a transition zone protein in primary cilia, cause diverse ciliopathies, including Leber congenital amaurosis (LCA) and Joubert-syndrome and related disorders (JSRD).
Hiroko Shimada   +14 more
doaj   +1 more source

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