Results 91 to 100 of about 9,240 (177)

Characterization of the disease-causing mechanism of KIF3B mutations from ciliopathy patients

Frontiers in Molecular Biosciences
The heterodimeric kinesin-2 motor (KIF3A/KIF3B with accessory protein KAP3) drives intraflagellar transport, essential for ciliogenesis and ciliary function. Three point mutations in the KIF3B subunit have recently been linked to disease in humans (E250Q
Jessica M. Adams, Caleb Sawe, Skye Rogers, Jordyn Reid, Ronith Dasari, Martin F. Engelke   +5 more
doaj   +1 more source

Editorial: The Cytoskeleton and Cellular Compartmentation: Cilia as Specialized Cellular Domains

Frontiers in Cell and Developmental Biology, 2021
Francesc R. Garcia-Gonzalo, Francesc R. Garcia-Gonzalo, Francesc R. Garcia-Gonzalo, Francesc R. Garcia-Gonzalo, Helena Soares, Helena Soares, Susana S. Lopes, Takanari Inoue, Takanari Inoue   +8 more
doaj   +1 more source

Primary cilia and actin regulatory pathways in renal ciliopathies

Frontiers in Nephrology
Ciliopathies are a group of rare genetic disorders caused by defects to the structure or function of the primary cilium. They often affect multiple organs, leading to brain malformations, congenital heart defects, and anomalies of the retina or skeletal ...
Rita Kalot, Rita Kalot, Zachary Sentell, Thomas M. Kitzler, Thomas M. Kitzler, Elena Torban, Elena Torban   +6 more
doaj   +1 more source

Enhanced Ciliogenesis of Human Bronchial Epithelial Cells by Simulated Microgravity

Life
Spaceflight induces a wide array of effects on the human body, notably including pathological changes mediated by alterations in gravity. Abnormalities in the formation of primary cilia (ciliogenesis) can lead to cell cycle arrest and decreased ...
Seung Hyun Bang, Soyoung Hwang, Seon Young Choi, Hyun Joo Kim, Joo Hyung Kim, Sung Ho Lee, Jin Woo Lee, Kuk Hui Son   +7 more
doaj   +1 more source

Use of Small-Molecule Inhibitors of CILK1 and AURKA as Cilia-Promoting Drugs to Decelerate Medulloblastoma Cell Replication

Biomedicines
Background/Objective: The primary cilium is the sensory organelle of a cell and a dynamic membrane protrusion during the cell cycle. It originates from the centriole at G0/G1 and undergoes disassembly to release centrioles for spindle formation before a ...
Sean H. Fu, Chelsea Park, Niyathi A. Shah, Ana Limerick, Ethan W. Powers, Cassidy B. Mann, Emily M. Hyun, Ying Zhang, David L. Brautigan, Sijie Hao, Roger Abounader, Zheng Fu   +11 more
doaj   +1 more source

Editorial: Signaling by primary cilia in development and disease

Frontiers in Cell and Developmental Biology, 2023
Sung-Eun Kim, Inna Nechipurenko, Søren Tvorup Christensen   +2 more
doaj   +1 more source

CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning. [PDF]

Genes Dev
Liu Y, Wang Z, Sinha T, Li KH, Chalkley RJ, Herranz-Pérez V, Xie C, Yoder BK, Burlingame AL, Black BL, Reiter JF.   +10 more
europepmc   +1 more source

Investigating the impact of poly(beta amino) ester-mediated FOXJ1 mRNA delivery on differentiation of primary human bronchial epithelial cells. [PDF]

Biol Open
Konstantinidi R, Subramanian M, Yates L, Lloyd CM, Saglani S, Patel AK.   +5 more
europepmc   +1 more source

Linking primary cilia defects to the "Big 3" neurodegenerative diseases - causal, consequential, or correlative? [PDF]

EXCLI J
Hor CHH, Tang BL.
europepmc   +1 more source

Primary ciliogenesis is promoted during epithelial-mesenchymal transition via a miR-200 - DZIP1 axis. [PDF]

Cell Commun Signal
Sourdin L, Bracken JM, Pillman KA, Bert AG, Goodall YK, Gregory PA, Goodall GJ, Bracken CP.   +7 more
europepmc   +1 more source