Results 101 to 110 of about 12,764 (170)

MLN4924: additional activities beyond neddylation inhibition

Molecular & Cellular Oncology, 2019
MLN4924, a small molecular inhibitor of NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) activating enzyme (NAE), blocks cullin neddylation to inactivate cullin-RING ligase. We found that MLN4924 has additional activities:
Qiyin Zhou, Yi Sun
doaj   +1 more source

Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein

, 2016
Fidgetin-like 1 (FIGL-1) is a homolog of fidgetin, an AAA protein that was identified as the protein encoded by the gene mutated in fidget mice. Because the phenotypes of fidget mice are reminiscent of the phenotypes of ciliopathy diseases, and because ...
Xiaoyu Zhao (197804), Mengzhu Wang (2867840), Lili Sun (162122), Xuejiao Hong (2867834), Chunguang Wang (115065), Miaomiao Jin (2867837), Ying Cao (170160)   +6 more
core   +1 more source

Assembly and mother centriole recruitment of IFT-B subcomplexes to form IFT-B holocomplex

Cell Structure and Function
For the biogenesis and maintenance of cilia, bidirectional protein trafficking within cilia is crucial, and is conducted by intraflagellar transport (IFT) trains containing the IFT-A and IFT-B complexes that are powered by dynein-2 and kinesin-II motors.
Koshi Tasaki, Yohei Katoh, Hye-Won Shin, Kazuhisa Nakayama   +3 more
doaj   +1 more source

Editorial: Advances in the research of diabetic nephropathy, volume II

Frontiers in Endocrinology, 2023
Katsumi Iizuka, Daisuke Yabe, Daisuke Yabe, Daisuke Yabe, Daisuke Yabe, Mohamed Abu-Farha, Jehad Abubaker, Fahd Al-Mulla   +7 more
doaj   +1 more source

Ulk4 is essential for ciliogenesis and csf flow

, 2016
Ciliopathies are an emerging class of devastating disorders with pleiotropic symptoms affecting both the central and peripheral systems and commonly associated with hydrocephalus. Even though ciliary components and three master transcriptional regulators
O'Brien, T., Lalor, P., Fitzgerald, U., Liu, M., Guan, Z., Shen, S., Shen, Q., Dockery, P.   +7 more
core   +1 more source

Characterization of the disease-causing mechanism of KIF3B mutations from ciliopathy patients

Frontiers in Molecular Biosciences
The heterodimeric kinesin-2 motor (KIF3A/KIF3B with accessory protein KAP3) drives intraflagellar transport, essential for ciliogenesis and ciliary function. Three point mutations in the KIF3B subunit have recently been linked to disease in humans (E250Q
Jessica M. Adams, Caleb Sawe, Skye Rogers, Jordyn Reid, Ronith Dasari, Martin F. Engelke   +5 more
doaj   +1 more source

Editorial: The Cytoskeleton and Cellular Compartmentation: Cilia as Specialized Cellular Domains

Frontiers in Cell and Developmental Biology, 2021
Francesc R. Garcia-Gonzalo, Francesc R. Garcia-Gonzalo, Francesc R. Garcia-Gonzalo, Francesc R. Garcia-Gonzalo, Helena Soares, Helena Soares, Susana S. Lopes, Takanari Inoue, Takanari Inoue   +8 more
doaj   +1 more source

Primary cilia and actin regulatory pathways in renal ciliopathies

Frontiers in Nephrology
Ciliopathies are a group of rare genetic disorders caused by defects to the structure or function of the primary cilium. They often affect multiple organs, leading to brain malformations, congenital heart defects, and anomalies of the retina or skeletal ...
Rita Kalot, Rita Kalot, Zachary Sentell, Thomas M. Kitzler, Thomas M. Kitzler, Elena Torban, Elena Torban   +6 more
doaj   +1 more source

Enhanced Ciliogenesis of Human Bronchial Epithelial Cells by Simulated Microgravity

Life
Spaceflight induces a wide array of effects on the human body, notably including pathological changes mediated by alterations in gravity. Abnormalities in the formation of primary cilia (ciliogenesis) can lead to cell cycle arrest and decreased ...
Seung Hyun Bang, Soyoung Hwang, Seon Young Choi, Hyun Joo Kim, Joo Hyung Kim, Sung Ho Lee, Jin Woo Lee, Kuk Hui Son   +7 more
doaj   +1 more source

Use of Small-Molecule Inhibitors of CILK1 and AURKA as Cilia-Promoting Drugs to Decelerate Medulloblastoma Cell Replication

Biomedicines
Background/Objective: The primary cilium is the sensory organelle of a cell and a dynamic membrane protrusion during the cell cycle. It originates from the centriole at G0/G1 and undergoes disassembly to release centrioles for spindle formation before a ...
Sean H. Fu, Chelsea Park, Niyathi A. Shah, Ana Limerick, Ethan W. Powers, Cassidy B. Mann, Emily M. Hyun, Ying Zhang, David L. Brautigan, Sijie Hao, Roger Abounader, Zheng Fu   +11 more
doaj   +1 more source