Results 111 to 120 of about 17,107 (226)

Temporal Nasal Epithelial Gene Expression Patterns in Healthy Individuals Infected With Rhinovirus‐16, and Its Modulation by Carrot Rhamnogalacturonan‐I

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Innate immune and interferon‐induced responses to in vivo nasal infection with rhinovirus (RV)16 in healthy subjects are accelerated by low‐dose dietary supplementation with carrot‐derived pectic polysaccharide rhamnogalacturonan‐I (cRG‐I), together with reduced duration and severity of symptoms.
Jasper Mol, Richard Volckmann, Abilash Ravi, Lara Ravanetti, Wim Calame, Sue McKay, Ruud Albers, Jan Koster, René Lutter   +8 more
wiley   +1 more source

Heat shock induces rapid resorption of primary cilia [PDF]

, 2012
Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Anckar, Baker, Berbari, Boyault, Breunig, Caspary, Corbit, Cotto, Davenport, Fliegauf, Gherman, Han, Haycraft, Kültz, Lange, McGlashan, Meimaridou, Nauli, Ng, Nigg, Overgaard, Pedersen, Pugacheva, Quarmby, Rohatgi, Rosenbaum, Schneider, Seeley, Singla, Taipale, Takaki, Weis, Williams   +32 more
core   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Identification of cilia genes that affect cell-cycle progression using whole-genome transcriptome analysis in Chlamydomonas reinhardtti [PDF]

, 2013
Cilia are microtubule based organelles that project from cells. Cilia are found on almost every cell type of the human body and numerous diseases, collectively termed ciliopathies, are associated with defects in cilia, including respiratory infections ...
Albee, Alison J, Dutcher, Susan K, Granas, David, Kwan, Alan L, Lin, Huawen, Stormo, Gary D   +5 more
core   +2 more sources

A Genetic Landscape of Euploid Miscarriages From Couples With Recurrent Pregnancy Loss Through Whole Exome Sequencing

Molecular Genetics &Genomic Medicine, Volume 14, Issue 4, April 2026.
Whole exome sequencing analysis on 55 couples and miscarriages from their current pregnancies reveals a significant heterogeneity and complexity in exomic variants contributing to RPL. ABSTRACT Background This study aimed to identify candidate genes for recurrent pregnancy loss (RPL).
Fanjuan Kong, Zhaochu Yin, Haiyan Zhou, Zhiyu Liu, Wanqin Xie   +4 more
wiley   +1 more source

The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium [PDF]

, 2014
The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, such as control of growth and ...
Kirschner, Marc W, Wang, Weiping, Wu, Tao   +2 more
core   +1 more source

Deficiency of calpain-6 inhibits primary ciliogenesis

BMB Reports, 2019
The primary cilium is a microtubule-based structure projecting from a cell. Although the primary cilium shows no motility, it can recognize environmental stimuli. Thus, ciliary defects cause severe abnormalities called ciliopathies. Ciliogenesis is a very complex process and involves a myriad of components and regulators. In order to excavate the novel
Kim, Bo Hye, Kim, Do Yeon, Oh, Sumin, Ko, Je Yeong, Rah, Gyuyeong, Yoo, Kyung Hyun, Park, Jong Hoon   +6 more
openaire   +3 more sources

VAMP7 modulates ciliary biogenesis in kidney cells [PDF]

, 2014
Epithelial cells elaborate specialized domains that have distinct protein and lipid compositions, including the apical and basolateral surfaces and primary cilia.
A Doyotte, A Le Bivic, Anatália Labilloy, B Chih, B Mandon, BA Potter, BA Rous, Catherine L. Jackson, Christina M. Szalinski, CM Szalinski, DC Ko, DE Gordon, DP Germain, E Boucrot, F Kotsis, F Lafont, G Ihrke, G Kreitzer, H Ishikawa, HA Hager, HM Kent, HT McMahon, IC Fields, J Kim, J Mazelova, Jennifer R. Bruns, JM Torkko, JR Henkel, JR Henkel, K Matter, KO Cresawn, L Breuza, L Danglot, L Milenkovic, LA Greene, LC Jones, M Chaineau, M Galvez-Santisteban, M Holt, M Steegmaier, MS Pols, MV Nachury, N Nishimura, N Sharma, OA Weisz, Ora A. Weisz, OV Vieira, PA Ortiz, PE Mattila, PR Pryor, PR Pryor, Q Hu, Q Zeng, R Jahn, R Le Borgne, RJ Advani, RJ Advani, RM Arantes, RW Tucker, S Breton, S Coco, S Hardy, S Martinez-Arca, SH Low, SK Rao, SM Leung, SV Costes, T Baust, T Galli, T Pocard, T Saito, T Takeda, V Proux-Gillardeaux, V Rossi, V Singla, X Li, X Zuo, Y Rbaibi, YC Hsiao   +78 more
core   +3 more sources

MLN4924: additional activities beyond neddylation inhibition

Molecular & Cellular Oncology, 2019
MLN4924, a small molecular inhibitor of NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) activating enzyme (NAE), blocks cullin neddylation to inactivate cullin-RING ligase. We found that MLN4924 has additional activities:
Qiyin Zhou, Yi Sun
doaj   +1 more source

Response of rat tracheal epithelium to ozone and oxygen exposure in vitro. [PDF]

, 1990
Although ozone-induced epithelial injury in vivo has been morphologically characterized, effects of gaseous oxidants on respiratory epithelium in organ culture, where tissue organization is maintained but systemic influences are eliminated, have not been
Nikula, KJ, Wilson, DW
core