Results 111 to 120 of about 11,577 (216)
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function
eLife, 2018 The dynein-2 microtubule motor is the retrograde motor for intraflagellar transport. Mutations in dynein-2 components cause skeletal ciliopathies, notably Jeune syndrome. Dynein-2 contains a heterodimer of two non-identical intermediate chains, WDR34 and
Laura Vuolo +3 more
doaj +1 more source
Peroxiredoxin5 controls vertebrate ciliogenesis by modulating mitochondrial ROS [PDF]
, 2019 Aims: Peroxiredoxin5 (Prdx5) - a thioredoxin peroxidase is an antioxidant enzyme that is widely studied for its antioxidant properties and protective roles in neurological and cardiovascular disorders.
Shin, Jong-Yeon +27 more
core +1 more source
Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis [PDF]
, 2019 About 1% of all newborns are affected by congenital heart disease (CHD). Recent findings identify aberrantly functioning cilia as a possible source for CHD.
Hempel, Maja +14 more
core +1 more source
Arl13b and the exocyst interact synergistically in ciliogenesis
Molecular Biology of the Cell, 2016 Arl13b belongs to the ADP-ribosylation factor family within the Ras superfamily of regulatory GTPases. Mutations in Arl13b cause Joubert syndrome, which is characterized by congenital cerebellar ataxia, hypotonia, oculomotor apraxia, and mental retardation.
Seixas, Cecília +13 more
openaire +2 more sources
Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein [PDF]
, 2016 Fidgetin-like 1 (FIGL-1) is a homolog of fidgetin, an AAA protein that was identified as the protein encoded by the gene mutated in fidget mice. Because the phenotypes of fidget mice are reminiscent of the phenotypes of ciliopathy diseases, and because ...
Xiaoyu Zhao (197804) +6 more
core +1 more source
Ciliogenesis, Ciliary Function, and Selective Isolation [PDF]
ACS Chemical Biology, 2008 In addition to their classic role in cell motility, certain cilia have sensory or signaling functions. In sea urchin embryos, short motile cilia randomly propel the early embryo, while a group of long, immotile cilia appear later, coincident with directional swimming and localized within a region that gives rise to the larval nervous system.
openaire +2 more sources
Determinants of cytoplasmic microtubule depolymerization during ciliogenesis in Chlamydomonas
Life Science AllianceChemically induced deciliation previously shown to induce cytoplasmic microtubule depolymerization occurs independently of ciliary loss. Furthermore, immediate ciliogenesis can occur in the presence of polymerized cytoplasmic microtubules. At the core of
Larissa L Dougherty, Prachee Avasthi
doaj +1 more source
Identifying novel regulators of ciliogenesis [PDF]
, 2020 Primary cilia are microtubule-based “antennae-like” organelles extending from the apical surface of most mammalian cells. They integrate mechanical or chemical signals essential for cell homeostasis and differentiation through several cooperating ...
Lake, Alice Verity Rosalind
core
MLN4924: additional activities beyond neddylation inhibition
Molecular & Cellular Oncology, 2019 MLN4924, a small molecular inhibitor of NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) activating enzyme (NAE), blocks cullin neddylation to inactivate cullin-RING ligase. We found that MLN4924 has additional activities:
Qiyin Zhou, Yi Sun
doaj +1 more source
Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy [PDF]
International audienceCentriolar satellites are high-order assemblies, scaffolded by the protein PCM1, that gravitate as particles around the centrosome and play pivotal roles in fundamental cellular processes notably ciliogenesis and autophagy.
Jardine, Jane +8 more
core +1 more source