KIF3A tail domain phosphorylation is not required for ciliogenesis in mouse embryonic fibroblasts
iScienceSummary: Primary cilia are essential signaling organelles that protrude from most cells in the body. Heterodimeric kinesin-2 (KIF3A/KIF3B/KAP3) powers several intracellular transport processes, including intraflagellar transport (IFT), essential for ...
Ayoola S. Fasawe +2 more
doaj +1 more source
Centrobin controls primary ciliogenesis in vertebrates [PDF]
, 2018 The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing to ablate CNTROB in hTERT-RPE1 cells and observed an increased frequency of monocentriolar and ...
Gaboriau, DCA +16 more
core +1 more source
The Spinocerebellar Ataxia-Associated Gene Tau Tubulin Kinase 2 Controls the Initiation of Ciliogenesis [PDF]
, 2012 SummaryThe primary cilium has critical roles in human development and disease, but the mechanisms that regulate ciliogenesis are not understood. Here, we show that Tau tubulin kinase 2 (TTBK2) is a dedicated regulator of the initiation of ciliogenesis in
Liem, Karel F. +2 more
core +1 more source
Regulation of INPP5E in Ciliogenesis, Development, and Disease
International Journal of Biological SciencesInositol polyphosphate-5-phosphatase E (INPP5E) is a 5-phosphatase critically involved in diverse physiological processes, including embryonic development, neurological function, immune regulation, hemopoietic cell dynamics, and macrophage proliferation, differentiation, and phagocytosis. Mutations in INPP5E cause Joubert and Meckel-Gruber syndromes in
Hakeem, Abdulaziz, Yang, Shuying
openaire +2 more sources
Assembly and mother centriole recruitment of IFT-B subcomplexes to form IFT-B holocomplex
Cell Structure and FunctionFor the biogenesis and maintenance of cilia, bidirectional protein trafficking within cilia is crucial, and is conducted by intraflagellar transport (IFT) trains containing the IFT-A and IFT-B complexes that are powered by dynein-2 and kinesin-II motors.
Koshi Tasaki +3 more
doaj +1 more source
Editorial: Advances in the research of diabetic nephropathy, volume II
Frontiers in Endocrinology, 2023 Katsumi Iizuka +7 more
doaj +1 more source
Characterization of the disease-causing mechanism of KIF3B mutations from ciliopathy patients
Frontiers in Molecular BiosciencesThe heterodimeric kinesin-2 motor (KIF3A/KIF3B with accessory protein KAP3) drives intraflagellar transport, essential for ciliogenesis and ciliary function. Three point mutations in the KIF3B subunit have recently been linked to disease in humans (E250Q
Jessica M. Adams +5 more
doaj +1 more source
Regulatory mechanism of ubiquitin-proteasome system-mediated ciliogenesis [PDF]
, 2020 application/pdf近年、一時繊毛(primary cilia)と呼ばれる細胞内小器官の形成不全および機能異常が、種々の発達異常や疾患(繊毛病)の原因となることが明らかになり、形成メカニズムの解明が喫緊の課題となっている。研究代表者は、増殖因子受容体によって活性化された脱ユビキチン化酵素USP8によるトリコプレインのタンパク質安定化が、増殖細胞において一次繊毛の形成抑制に働いていることを明らかにした。Ciliogenesis is generally inhibited in dividing
笠原, 広介 +2 more
core
Primary cilia and actin regulatory pathways in renal ciliopathies
Frontiers in NephrologyCiliopathies are a group of rare genetic disorders caused by defects to the structure or function of the primary cilium. They often affect multiple organs, leading to brain malformations, congenital heart defects, and anomalies of the retina or skeletal ...
Rita Kalot +6 more
doaj +1 more source
Editorial: The Cytoskeleton and Cellular Compartmentation: Cilia as Specialized Cellular Domains
Frontiers in Cell and Developmental Biology, 2021 Francesc R. Garcia-Gonzalo +8 more
doaj +1 more source