Results 121 to 130 of about 17,107 (226)
Determinants of cytoplasmic microtubule depolymerization during ciliogenesis in Chlamydomonas
Life Science AllianceChemically induced deciliation previously shown to induce cytoplasmic microtubule depolymerization occurs independently of ciliary loss. Furthermore, immediate ciliogenesis can occur in the presence of polymerized cytoplasmic microtubules. At the core of
Larissa L Dougherty, Prachee Avasthi
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Apico-basal polarity determinants encoded by crumbs genes affect ciliary shaft protein composition, IFT movement dynamics, and cilia length [PDF]
, 2017 One of the most obvious manifestations of polarity in epithelia is the subdivision of the cell surface by cell junctions into apical and basolateral domains. crumbs genes are among key regulators of this form of polarity. Loss of crumbs function disrupts
Hazime, K., Malicki, J.J.
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Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. [PDF]
, 2016 Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of ...
Bardsley, Michael R +18 more
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eLife, 2016 Upon cell cycle exit, centriole-to-basal body transition facilitates cilia formation. The centriolar protein Cp110 is a regulator of this process and cilia inhibitor, but its positive roles in ciliogenesis remain poorly understood.
Peter Walentek +5 more
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Targeting GLI factors to inhibit the Hedgehog pathway [PDF]
, 2015 Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although
Alfonsi, Romina +4 more
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Choanoflagellate Ciliogenesis Live Imaging v2
, 2023 This protocol removes the cilia/flagella from choanoflagellate cells and sets up the cells for live imaging of ciliogenesis. It has been developed for the species Salpingoeca rosetta, but may be portable into other choanoflagellate species. Cells begin to re-generate their cilia/flagella right after removal. The idea of using a cold shock with glycerol
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Assembly and mother centriole recruitment of IFT-B subcomplexes to form IFT-B holocomplex
Cell Structure and FunctionFor the biogenesis and maintenance of cilia, bidirectional protein trafficking within cilia is crucial, and is conducted by intraflagellar transport (IFT) trains containing the IFT-A and IFT-B complexes that are powered by dynein-2 and kinesin-II motors.
Koshi Tasaki +3 more
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Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis [PDF]
, 2012 BACKGROUND: Clusterin associated protein 1 (CLUAP1) was initially characterized as a protein that interacts with clusterin, and whose gene is frequently upregulated in colon cancer. Although the consequences of these observations remain unclear, research
Bradley K Yoder +4 more
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Nature Communications, 2018 Ciliogenesis is negatively regulated by the CP110-CEP97 complex, although the mechanism controlling mother centriole localization is poorly understood. Here, Huang et al.
Ning Huang +6 more
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A Molecular Dissection of Ciliogenesis
The FASEB Journal, 2006 Cilia are known to be crucial for many developmental and physiological processes, yet cilia biogenesis and maintenance are not well understood. In particular, apart from intraflagellar transport proteins, molecular players in the process of ciliogenesis are largely unknown. Two recent studies utilizing the unicellular green alga
Elisa Sandoval Kannegaard +1 more
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