Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function
eLife, 2018 The dynein-2 microtubule motor is the retrograde motor for intraflagellar transport. Mutations in dynein-2 components cause skeletal ciliopathies, notably Jeune syndrome. Dynein-2 contains a heterodimer of two non-identical intermediate chains, WDR34 and
Laura Vuolo +3 more
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Arl13b and the exocyst interact synergistically in ciliogenesis
Molecular Biology of the Cell, 2016 Arl13b belongs to the ADP-ribosylation factor family within the Ras superfamily of regulatory GTPases. Mutations in Arl13b cause Joubert syndrome, which is characterized by congenital cerebellar ataxia, hypotonia, oculomotor apraxia, and mental retardation.
Seixas, Cecília +13 more
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Ciliogenesis, Ciliary Function, and Selective Isolation [PDF]
ACS Chemical Biology, 2008 In addition to their classic role in cell motility, certain cilia have sensory or signaling functions. In sea urchin embryos, short motile cilia randomly propel the early embryo, while a group of long, immotile cilia appear later, coincident with directional swimming and localized within a region that gives rise to the larval nervous system.
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Determinants of cytoplasmic microtubule depolymerization during ciliogenesis in Chlamydomonas
Life Science AllianceChemically induced deciliation previously shown to induce cytoplasmic microtubule depolymerization occurs independently of ciliary loss. Furthermore, immediate ciliogenesis can occur in the presence of polymerized cytoplasmic microtubules. At the core of
Larissa L Dougherty, Prachee Avasthi
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MLN4924: additional activities beyond neddylation inhibition
Molecular & Cellular Oncology, 2019 MLN4924, a small molecular inhibitor of NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) activating enzyme (NAE), blocks cullin neddylation to inactivate cullin-RING ligase. We found that MLN4924 has additional activities:
Qiyin Zhou, Yi Sun
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The dynamics of ciliogenesis in prepubertal mouse meiosis reveals new clues about testis maturation
Frontiers in Cell and Developmental BiologyPrimary cilia have recently been identified in mammalian spermatocytes, but their developmental regulation during testicular maturation remains poorly understood.
I. Pérez-Moreno +20 more
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KIF3A tail domain phosphorylation is not required for ciliogenesis in mouse embryonic fibroblasts
iScienceSummary: Primary cilia are essential signaling organelles that protrude from most cells in the body. Heterodimeric kinesin-2 (KIF3A/KIF3B/KAP3) powers several intracellular transport processes, including intraflagellar transport (IFT), essential for ...
Ayoola S. Fasawe +2 more
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Regulation of INPP5E in Ciliogenesis, Development, and Disease
International Journal of Biological SciencesInositol polyphosphate-5-phosphatase E (INPP5E) is a 5-phosphatase critically involved in diverse physiological processes, including embryonic development, neurological function, immune regulation, hemopoietic cell dynamics, and macrophage proliferation, differentiation, and phagocytosis. Mutations in INPP5E cause Joubert and Meckel-Gruber syndromes in
Hakeem, Abdulaziz, Yang, Shuying
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Assembly and mother centriole recruitment of IFT-B subcomplexes to form IFT-B holocomplex
Cell Structure and FunctionFor the biogenesis and maintenance of cilia, bidirectional protein trafficking within cilia is crucial, and is conducted by intraflagellar transport (IFT) trains containing the IFT-A and IFT-B complexes that are powered by dynein-2 and kinesin-II motors.
Koshi Tasaki +3 more
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Editorial: Advances in the research of diabetic nephropathy, volume II
Frontiers in Endocrinology, 2023 Katsumi Iizuka +7 more
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