Results 81 to 90 of about 11,577 (216)

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

Life Science Alliance, 2021
Pathogenic LRRK2 phosphorylation of Rab10 GTPase dramatically redistributes Myosin Va and RILPL2 proteins to the mother centriole and sequesters Myosin Va at that location in a manner that likely interferes with its role in ciliogenesis.
Herschel S Dhekne, Izumi Yanatori, Edmundo G Vides, Yuriko Sobu, Federico Diez, Francesca Tonelli, Suzanne R Pfeffer   +6 more
doaj   +1 more source

Prostaglandin signaling in ciliogenesis during development [PDF]

Cell Cycle, 2014
Prostaglandins regulate a wide variety of physiological and pathological processes, including inflammation, reproduction, cardiovascular homeostasis, and cancer progression. Cyclooxygenase (COX) catalyzes the rate-limiting step in the production of prostaglandins from arachidonic acid (Fig. 1). In 2 reaction steps, arachidonic acid is firstly converted
Daqing, Jin, Peiyun, Liu, Tao P, Zhong
openaire   +2 more sources

GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base

eLife, 2022
The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction protein α1 (GJA1) is the most commonly expressed subunit.
Dong Gil Jang, Keun Yeong Kwon, Yeong Cheon Kweon, Byung-gyu Kim, Kyungjae Myung, Hyun-Shik Lee, Chan Young Park, Taejoon Kwon, Tae Joo Park   +8 more
doaj   +1 more source

Phenotypic Expansion and Molecular Implications in Recessive FUZ ‐Related Ciliopathy

Clinical Genetics, Volume 110, Issue 2, Page 236-241, August 2026.
Our patient with homozygous FUZ p.Arg234Trp, potentially altering FUZ‐CPLANE2 interactions, presented with aorto‐pulmonary window, Hirschsprung disease, and shared phenotypes with previously reported ciliopathy patients. This report provides additional evidence for FUZ as a causative gene for ciliopathy, offering novel insights into the phenotype ...
Yosuke Ogawa, Shota Kato, Kazuhiro Shiraga, Motohiro Kato, Ryo Inuzuka   +4 more
wiley   +1 more source

Primary cilia–extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative condition marked by cognitive decline and synaptic issues. Recent studies show primary cilia (PCs), sensory organelles present on the surface of most mammalian cells, act as a critical regulators of brain homeostasis and signaling.
Vishal Singh Guleria, Charisse N. Winston   +1 more
wiley   +1 more source

Myh10 Counteracts Myh9 Activity to Promote Ciliogenesis. [PDF]

, 2014
(A) Myh10 and Myh9 displayed opposing activity on ciliogenesis. IMCD3 cells were stably transfected with pCR3.1 vector (left panel, upper row), CMV-Myh9-GFP (left panel, bottom row) and CMV-Myh10-GFP (left panel, middle row) and grew to confluence to ...
Yanhua Rao (321257), Rui Hao (9775), Tso-Pang Yao (15280), Bin Wang (30851)   +3 more
core   +1 more source

Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation

Nature Communications
WDR44 prevents ciliogenesis initiation by regulating RAB11-dependent vesicle trafficking. Here, we describe male patients with missense and nonsense variants within the WD40 repeats (WDR) of WDR44, an X-linked gene product, who display ciliopathy-related
Andrea Accogli, Saurabh Shakya, Taewoo Yang, Christine Insinna, Soo Yeon Kim, David Bell, Kirill R. Butov, Mariasavina Severino, Marcello Niceta, Marcello Scala, Hyun Sik Lee, Taekyeong Yoo, Jimmy Stauffer, Huijie Zhao, Chiara Fiorillo, Marina Pedemonte, Maria C. Diana, Simona Baldassari, Viktoria Zakharova, Anna Shcherbina, Yulia Rodina, Christina Fagerberg, Laura Sønderberg Roos, Jolanta Wierzba, Artur Dobosz, Amanda Gerard, Lorraine Potocki, Jill A. Rosenfeld, Seema R. Lalani, Tiana M. Scott, Daryl Scott, Mahshid S. Azamian, Raymond Louie, Hannah W. Moore, Neena L. Champaigne, Grace Hollingsworth, Annalaura Torella, Vincenzo Nigro, Rafal Ploski, Vincenzo Salpietro, Federico Zara, Simone Pizzi, Giovanni Chillemi, Marzia Ognibene, Erin Cooney, Jenny Do, Anders Linnemann, Martin J. Larsen, Suzanne Specht, Kylie J. Walters, Hee-Jung Choi, Murim Choi, Marco Tartaglia, Phillippe Youkharibache, Jong-Hee Chae, Valeria Capra, Sung-Gyoo Park, Christopher J. Westlake   +57 more
doaj   +1 more source

Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina

Cell Reports, 2016
Summary: Microtubule actin crosslinking factor 1 (MACF1) plays a role in the coordination of microtubules and actin in multiple cellular processes. Here, we show that MACF1 is also critical for ciliogenesis in multiple cell types.
Helen L. May-Simera, Jessica D. Gumerson, Chun Gao, Maria Campos, Stephanie M. Cologna, Tina Beyer, Karsten Boldt, Koray D. Kaya, Nisha Patel, Friedrich Kretschmer, Matthew W. Kelley, Ronald S. Petralia, Megan G. Davey, Tiansen Li   +13 more
doaj   +1 more source

Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice

Andrology, Volume 14, Issue 5, Page 1240-1248, July 2026.
ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang, Anh Hoang Pham, Mengjiao Luo, Masahito Ikawa, Haruhiko Miyata   +4 more
wiley   +1 more source

ELECTRON MICROSCOPICAL OBSERVATIONS ON THE TRACHEAL EPITHELIUM OF THE ONE-HUMPED CAMEL (CAMELUS DROMEDARIUS) WITH SPECIAL REFERENCE TO CILIOGENESIS [PDF]

Assiut Veterinary Medical Journal, 1999
This study was carried out on 10 adult, apparently healthy one-humped camels of different ages and of both sexes. The ultrastructure of camel tracheal epithelium was studied by scanning and transmission electron microscopes.
Yousria A. Abd El-Rahman
doaj   +1 more source