Results 61 to 70 of about 12,764 (170)

Myh10 Is Upregulated During Ciliogenesis.

, 2014
(A) Schematic illustration of selected gene expression analysis during ciliogenesis in time course. (B) Myh10 protein level is upregulated during ciliogenesis. RPE-Mchr1GFP cells serum starved (0.2% FBS) for 0, 1, 2, 6, 12 and 24 hours were collected for
Yanhua Rao (321257), Rui Hao (9775), Tso-Pang Yao (15280), Bin Wang (30851)   +3 more
core   +1 more source

EFA6A, an exchange factor for Arf6, regulates early steps in ciliogenesis

, 2021
International audienceABSTRACT Ciliogenesis is a coordinated process initiated by the recruitment and fusion of pre-ciliary vesicles at the distal appendages of the mother centriole through mechanisms that remain unclear. Here, we report that EFA6A (also
Pagnotta, Sophie, Macia, Eric, Brau, Frédéric, Ghossoub, Rania, Fayad, Racha, Abélanet, Sophie, Baron, Carole, Partisani, Mariagrazia, Baron, Carole, L, Lacas-Gervais, Sandra, Benmerah, Alexandre, Franco, Michel, Luton, Frédéric, Racha Fayad, Frédéric Luton, Mariagrazia Partisani, Rania Ghossoub, Sophie Pagnotta, Baron, Carole,, Eric Macia, Michel Franco, Frédéric Brau, Sandra Lacas-Gervais, Alexandre Benmerah, Sophie Abélanet, Carole L. Baron   +25 more
core   +1 more source

Oleic and linoleic acids induce oxidative stress in chondrocytes by inhibiting autophagy‐regulated ciliogenesis

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The lack of a cure for osteoarthritis (OA), a prevalent joint disease among older individuals, remains an ongoing challenge. Obesity is a common risk factor for OA. Chondrocyte autophagy plays a crucial role in delaying the onset of OA.
Xiaodong Li, Chuanyuan Mao, Guantong Sun, Chen Zhao, Jingjing Dai, Fei Yang, Lei Wang, Xiaoqing Wang   +7 more
doaj   +1 more source

Identification of Novel Interacting Proteins of FUZ and GPR161

PROTEOMICS, EarlyView.
ABSTRACT Protein–protein interactions are central to the dynamic regulation of signaling pathways and provide critical insight into the cellular mechanisms underlying human disease. Our previous study demonstrated biochemical and genetic interactions between FUZ and GPR161 in sonic hedgehog signaling during spinal neural tube development. In this study,
Gabriella Salazar, Anna Battenhouse, Andrew J. Kim, Sung‐Eun Kim   +3 more
wiley   +1 more source

Screen-based identification and validation of four novel ion channels as regulators of renal ciliogenesis [PDF]

, 2015
To investigate the contribution of ion channels to ciliogenesis we carried out an siRNA-based reverse genetics screen of all ion channels in the mouse genome in murine inner medullary collecting duct kidney cells.
Keijzer-Veen, Mandy G., Giles, Rachel H., Giles, Rachel H, Den Ouden, K., Knoers, NV, van Balkom, B. W. M., Szymanska, K, Lilien, Marc R., Knoers, Nine V., Lilien, MR, Den Ouden, Krista, Knoers, Nine V, Keijzer-Veen, MG, Keijzer-Veen, Mandy G, van Balkom, Bas W.M., Slaats, Gisela G., Den Ouden, K, Logister, I, Johnson, CA, Szymanska, Katarzyna, Johnson, Colin A., Slaats, Gisela G, Wheway, G, Foletto, V, van Balkom, BWM, Foletto, Veronica, van Balkom, Bas W M, Lilien, Marc R, Ouden, Krista Den, Slaats, GG, Johnson, Colin A, Giles, RH, Wheway, Gabrielle, Logister, Ive, Regenerative Medicine and Stem Cells, Genetica, Nefro Vasculaire Geneeskunde, Nefrologie, Child Health, Nefrologie patientenzorg, MS Nefrologie, Circulatory Health   +41 more
core   +1 more source

Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons

, 2021
Mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent cause of familial Parkinson's disease (PD). The increase in LRRK2 kinase activity observed in the pathogenic G2019S mutation is important for PD development.
Joo-Eun Lee, S W Park, H J Choi, Hyejung Kim, Wongi Seol, Seo-Young Lee, I Son, H Kim, D Nam, Sun-Ku Chung, Hyun Jin Choi, Ilhong Son, M K Seo, S K Chung, Yeojin Bang, Janghwan Kim, W Seol, Mi Kyoung Seo, Hyuna Sim, S Y Lee, Sung Woo Park, Daleum Nam, J Lim, Y Bang, Juhee Lim   +24 more
core   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source

Rare Novel Genetic Variants of the OFD1 Gene Associated With a Familial Form and a Sporadic Case of Long Bone Atypical Fractures

Clinical Genetics, EarlyView.
A novel rare variant of the OFD1 gene was identified in a family with dental hypoplasia, facial hypoplasia, and adult‐onset multiple atypical fractures of long bones. Another variant of the OFD1 gene was found in a woman with bisphosphonate‐associated atypical femur fracture.
Marie‐Ève Boisvert, Halim Maaroufi, Rachel Laframboise, Frédéric Fournier, Suzanne N. Morin, Edith Gagnon, Claudia Gagnon, Fabrice Mac‐Way, Mahmoud Rouabhia, Louis‐Georges Ste‐Marie, Arnaud Droit, Jacques P. Brown, Laëtitia Michou   +12 more
wiley   +1 more source

RFX2 is broadly required for ciliogenesis during vertebrate development

, 2014
In Caenorhabditis elegans, the RFX (Daf19) transcription factor is a major regulator of ciliogenesis, controlling the expression of the many essential genes required for making cilia.
Park, Tae Joo, Wallingford, John B., Chung, Mei-I, LeBoeuf, Sarah, Marcotte, Edward M., McGary, Kriston L., Peyrot, Sara M.   +6 more
core   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source