Results 61 to 70 of about 11,577 (216)

Counterregulation of cAMP-directed kinase activities controls ciliogenesis [PDF]

, 2018
The primary cilium emanates from the cell surface of growth-arrested cells and plays a central role in vertebrate development and tissue homeostasis. The mechanisms that control ciliogenesis have been extensively explored.
Daniela Intartaglia, Matthis Synofzik, Luigi Insabato, Rossella Delle Donne, Verena A. Bachmann, Eduard Stefan, Omar Torres-Quesada, Antonio Feliciello, Simona Sauchella, Ivan Conte, Maria Sepe, Corrado Garbi, Margherita Santoriello, Monia Porpora, Laura Rinaldi, Herbert H. Lindner   +15 more
core   +4 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Lack of a Retinal Phenotype in a Syne-2/Nesprin-2 Knockout Mouse Model

Cells, 2019
Syne-2 (also known as Nesprin-2) is a member of a family of proteins that are found primarily in the outer nuclear membrane, as well as other subcellular compartments.
Nathalie Falk, Anneka Joachimsthaler, Kristin Kessler, Uwe Thorsten Lux, Angelika Anna Noegel, Jan Kremers, Johann Helmut Brandstätter, Andreas Gießl   +7 more
doaj   +1 more source

Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy, Jesse Richards, Brooke R. Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma McGibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales   +16 more
wiley   +1 more source

Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo [PDF]

, 2018
The primary cilia are evolutionarily conserved microtubule-based cellular organelles that perceive metabolic status and thus link the sensory system to cellular signaling pathways.
Goo Taeg Oh (581951), Kyunghee Byun (162379), Yunash Maharjan (5233262), Seong-Kyu Choe (256094), Zhi-qiang Liu (1364745), Raekil Park (224445), Jae-Young Lim (519753), Raghbendra Kumar Dutta (5233265), SeongAe Kwak (5233268), Joon No Lee (5233271), Myeongjoo Son (618788)   +10 more
core   +5 more sources

Identification of novel genes regulating the development of the palate

Developmental Dynamics, EarlyView.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

Kinesin-2 family in vertebrate ciliogenesis [PDF]

Proceedings of the National Academy of Sciences, 2012
The differentiation of cilia is mediated by kinesin-driven transport. As the function of kinesins in vertebrate ciliogenesis is poorly characterized, we decided to determine the role of kinesin-2 family motors—heterotrimeric kinesin-II and the homodimeric Kif17 kinesin—in zebrafish cilia.
Chengtian, Zhao, Yoshihiro, Omori, Katarzyna, Brodowska, Peter, Kovach, Jarema, Malicki   +4 more
openaire   +2 more sources

ODF2L is a negative regulator of ciliogenesis [PDF]

, 2018
The centrosome is a subcellular organelle whose main role is acting as a microtubule organising centre (MTOC). It consists of two barrel-shaped centrioles surrounded by the pericentriolar matrix.
De Saram, Paulu
core  

Rapid Ex-Vivo Ciliogenesis and Dose-Dependent Effect of Notch Inhibition on Ciliogenesis of Respiratory Epithelia [PDF]

Biomolecules, 2020
Background: Cilia are actin based cellular protrusions conserved from algae to complex multicellular organisms like Homo sapiens. Respiratory motile cilia line epithelial cells of the tracheobronchial tree, beat in a synchronous, metachronal wave, moving inhaled pollutants and pathogens cephalad.
Maliha Zahid, Timothy N. Feinstein, Anthony Oro, Molly Schwartz, Alex D. Lee, Cecilia W. Lo   +5 more
openaire   +5 more sources