Results 11 to 20 of about 12,764 (170)

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis [PDF]

Nature Communications, 2019
Ciliogenesis is a complex process requiring hundreds of molecules, although few secreted proteins have been implicated. Here, the authors show that the secreted metalloproteases ADAMTS9 and ADAMTS20 intracellularly regulate ciliogenesis from unique ...
Timothy C Cox, Suneel S Apte, Sumeda Nandadasa   +2 more
exaly   +3 more sources

Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis [PDF]

eLife, 2023
Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by Pericentriolar material 1 (PCM1). To study the requirement for centriolar satellites, we generated mice lacking PCM1, a crucial component of satellites. Pcm1−/−
Emma A Hall, Dhivya Kumar, Suzanna L Prosser, Patricia L Yeyati, Vicente Herranz-Pérez, Jose Manuel García-Verdugo, Lorraine Rose, Lisa McKie, Daniel O Dodd, Peter A Tennant, Roly Megaw, Laura C Murphy, Marisa F Ferreira, Graeme Grimes, Lucy Williams, Tooba Quidwai, Laurence Pelletier, Jeremy F Reiter, Pleasantine Mill   +18 more
doaj   +4 more sources

The multifaceted role of EXOC6A in ciliogenesis [PDF]

eLife
Ciliogenesis is a highly ordered process that requires membrane trafficking, fusion, and maturation. In this study, we investigated EXOC6A, a component of the exocyst complex known for secretory vesicle trafficking and fusion, and found that it interacts
Te-Lin Lin, Chien-Ting Wu, Tang K Tang
doaj   +2 more sources

FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly

Frontiers in Cell and Developmental Biology, 2020
Primary cilia are microtubule-based, antenna-like organelles, which are formed in G0 phase and resorbed as cells re-enter the cell cycle. It has been reported that primary cilia can influence the timing of cell cycle progression.
Huadong Jiang, Shanshan Liu, Man-Hei Cheung, Aftab Amin, Chun Liang, Chun Liang, Chun Liang, Chun Liang   +7 more
doaj   +2 more sources

Robust interaction of IFT70 with IFT52–IFT88 in the IFT-B complex is required for ciliogenesis

Biology Open, 2018
In the intraflagellar transport (IFT) machinery, the IFT-B and IFT-A complexes mediate anterograde and retrograde ciliary protein trafficking, respectively.
Ryota Takei, Yohei Katoh, Kazuhisa Nakayama   +2 more
doaj   +3 more sources

Carnitine Protects against MPP⁺-Induced Neurotoxicity and Inflammation by Promoting Primary Ciliogenesis in SH-SY5Y Cells

Cells, 2022
Primary cilia help to maintain cellular homeostasis by sensing conditions in the extracellular environment, including growth factors, nutrients, and hormones that are involved in various signaling pathways.
Ji-Eun Bae, Joon Bum Kim, Doo Sin Jo, Na Yeon Park, Yong Hwan Kim, Ha Jung Lee, Seong Hyun Kim, So Hyun Kim, Mikyung Son, Pansoo Kim, Hong-Yeoul Ryu, Won Ha Lee, Zae Young Ryoo, Hyun-Shik Lee, Yong-Keun Jung, Dong-Hyung Cho   +15 more
doaj   +2 more sources

BICD2 promotes ciliogenesis by facilitating CP110 removal from the mother centriole

EMBO Reports
Cilia are hair-like organelles that protrude from the cell surface and play vital roles in embryonic development and tissue homeostasis. Removal of centriolar coiled-coil protein 110 (CP110) from the mother centriole is a critical step in ciliogenesis ...
Wenjun Kuang, Hao Jin, Shanshan Xie, Guangshuo Ou, Tianhua Zhou   +4 more
doaj   +2 more sources

GRAF1-dependent endocytotic processes and the Golgi apparatus contribute to previously unrecognized intermediate stages of early ciliogenesis [PDF]

Nature Communications
The intracellular cilia assembly pathway is a complex, multistep process that requires the continuous and coordinated incorporation of membrane material. However, how membrane remodeling occurs during early ciliogenesis is not yet understood.
Kerstin N. Schmidt, Korbinian Buerger, Olga Maier, Anita Zügner, Larissa Osten, Patrick Hofstetter, Helga Othmen, Yulia Zaytseva, Anita Hecht, Clarissa Read, Reinhard Rachel, Ralph Witzgall   +11 more
doaj   +2 more sources

The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms

Biology Open, 2013
Summary We previously reported that the small nuclear RNA processing complex, Integrator, is required for dynein recruitment to the nuclear envelope at mitotic onset in cultured human cells.
Jeanne N. Jodoin, Mohammad Shboul, Todd R. Albrecht, Ethan Lee, Eric J. Wagner, Bruno Reversade, Laura A. Lee   +6 more
doaj   +2 more sources

Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites

Cell Reports, 2020
Summary: Primary cilium is an antenna-like microtubule-based cellular sensing structure. Abnormal regulation of the dynamic assembly and disassembly cycle of primary cilia is closely related to ciliopathy and cancer.
Mi-Lang Kyun, Sun-Ok Kim, Hee Gu Lee, Jeong-Ah Hwang, Joonsung Hwang, Nak-Kyun Soung, Hyunjoo Cha-Molstad, Sangku Lee, Yong Tae Kwon, Bo Yeon Kim, Kyung Ho Lee   +10 more
doaj   +2 more sources