Results 11 to 20 of about 9,240 (177)
JMA Journal, 2021 Autophagy is a major intracellular degradation system and plays important roles in various physiological processes such as metabolic adaptation and intracellular homeostasis. It degrades intracellular components both randomly and selectively. Autophagic activity is tightly regulated primarily by nutrient availability, but also by other extracellular ...
Yamamoto, Yasuhiro, Mizushima, Noboru
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TRIP6 functions in brain ciliogenesis [PDF]
Nature Communications, 2021 AbstractTRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion component.Trip6deletion in the mouse, reported here, reveals a function in the brain: ependymal and choroid plexus epithelial cells are carrying, unexpectedly, fewer and shorter cilia, are poorly differentiated, and the mice develop hydrocephalus.
Shalmali Shukla +13 more
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Cells, 2022 Primary cilia help to maintain cellular homeostasis by sensing conditions in the extracellular environment, including growth factors, nutrients, and hormones that are involved in various signaling pathways.
Ji-Eun Bae +15 more
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Mechanobiology of Ciliogenesis [PDF]
BioScience, 2014 Cilia are force-generating and -sensing organelles that serve as mechanical interfaces between the cell and the extracellular environment. Cilia are present in tissues that adaptively respond to mechanical loading and fluid flow, and defects in ciliary function can lead to diseases affecting these tissues.
Ishikawa, Hiroaki, Marshall, Wallace F
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Ionizing radiation promotes primary ciliogenesis in glioblastoma cells
Fushe yanjiu yu fushe gongyi xuebao, 2021 The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei +5 more
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Ciliogenesis membrane dynamics and organization
Seminars in Cell & Developmental Biology, 2023 Ciliogenesis is a complex multistep process used to describe assembly of cilia and flagella. These organelles play essential roles in motility and signaling on the surface of cells. Cilia are built at the distal ends of centrioles through the formation of an axoneme that is surrounded by the ciliary membrane.
Huijie, Zhao +2 more
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Frontiers in Cell and Developmental Biology, 2020 Primary cilia are microtubule-based, antenna-like organelles, which are formed in G0 phase and resorbed as cells re-enter the cell cycle. It has been reported that primary cilia can influence the timing of cell cycle progression.
Huadong Jiang +7 more
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CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis
BMC Biology, 2023 Background The axonemal microtubules of primary cilium undergo a conserved protein posttranslational modification (PTM) — polyglutamylation. This reversible procedure is processed by tubulin tyrosine ligase-like polyglutamylases to form secondary ...
Yujuan Wang +6 more
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Molecular Brain, 2023 The primary cilium, an antenna-like structure on the cell surface, acts as a mechanical and chemical sensory organelle. Primary cilia play critical roles in sensing the extracellular environment to coordinate various developmental and homeostatic ...
Ji-Eun Bae +17 more
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Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis
eLife, 2023 Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by Pericentriolar material 1 (PCM1). To study the requirement for centriolar satellites, we generated mice lacking PCM1, a crucial component of satellites. Pcm1−/−
Emma A Hall +18 more
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