Results 11 to 20 of about 11,577 (216)

TRIP6 functions in brain ciliogenesis [PDF]

Nature Communications, 2021
TRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion compo- nent. Trip6 deletion in the mouse, reported here, reveals a function in the brain: ependymal and choroid plexus epithelial cells are carrying, unexpectedly,
Herrlich, Peter, Nagel, Sigrun, Tapias, Alicia, Kassel, Olivier, Urbánek, Pavel, Ploubidou, Aspasia, Shukla, Shalmali, Frappart, Lucien, Haenold, Ronny, Wang, Zhao-Qi, Monajembashi, Shamci, Grigaravicius, Paulius, Heuer, Heike, min, wookee, Min, Woo Kee   +14 more
core   +9 more sources

Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis [PDF]

eLife, 2023
Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by Pericentriolar material 1 (PCM1). To study the requirement for centriolar satellites, we generated mice lacking PCM1, a crucial component of satellites. Pcm1−/−
Emma A Hall, Dhivya Kumar, Suzanna L Prosser, Patricia L Yeyati, Vicente Herranz-Pérez, Jose Manuel García-Verdugo, Lorraine Rose, Lisa McKie, Daniel O Dodd, Peter A Tennant, Roly Megaw, Laura C Murphy, Marisa F Ferreira, Graeme Grimes, Lucy Williams, Tooba Quidwai, Laurence Pelletier, Jeremy F Reiter, Pleasantine Mill   +18 more
doaj   +6 more sources

Mechanobiology of Ciliogenesis [PDF]

BioScience, 2014
Cilia are force-generating and -sensing organelles that serve as mechanical interfaces between the cell and the extracellular environment. Cilia are present in tissues that adaptively respond to mechanical loading and fluid flow, and defects in ciliary ...
Wallace F. Marshall, Marshall, Wallace F, Hiroaki Ishikawa, Ishikawa, Hiroaki   +3 more
core   +6 more sources

Induction of Ran GTP drives ciliogenesis [PDF]

Molecular Biology of the Cell, 2011
The small GTPase Ran and the importin proteins regulate nucleocytoplasmic transport. New evidence suggests that Ran GTP and the importins are also involved in conveying proteins into cilia.
Martens, Jeffrey R, Sajjan, Uma, Ben Margolis, Margolis, Ben, Shuling Fan, Verhey, Kristen J, Toby W. Hurd, Dishinger, John F, Kristen J. Verhey, Jeffrey R. Martens, Hurd, Toby W, Chia Jen Liu, Eileen L. Whiteman, Uma Sajjan, Whiteman, Eileen L, Liu, Chia Jen, Fan, Shuling, McIntyre, Jeremy C, Jeremy C. McIntyre, John F. Dishinger   +19 more
core   +4 more sources

EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase [PDF]

Nature Communications, 2018
The trichoplein-Aurora A pathway inhibits ciliogenesis in proliferating cells. Here the authors EGFR-mediated phosphorylation of the deubiquitinating enzyme USP8 leads to its activation, and this suppresses trichoplein degradation, allowing inhibition of
Kousuke Kasahara, Hiromasa Aoki, Tohru Kiyono, Shujie Wang, Harumi Kagiwada, Mizuki Yuge, Toshio Tanaka, Yuhei Nishimura, Akira Mizoguchi, Naoki Goshima, Masaki Inagaki   +10 more
doaj   +2 more sources

Motile ciliogenesis and the mitotic prism [PDF]

Biology of the Cell, 2019
International audienceMotile cilia of epithelial multiciliated cells transport vital fluids along organ lumens to promote essential respiratory, reproductive and brain functions.
Meunier, Alice, Adel Al Jord, Al Jord, Adel, Alice Meunier, Spassky, Nathalie, Nathalie Spassky   +5 more
core   +3 more sources

Ulk4 is essential for ciliogenesis and csf flow [PDF]

Journal of Neuroscience, 2016
Ciliopathies are an emerging class of devastating disorders with pleiotropic symptoms affecting both the central and peripheral systems and commonly associated with hydrocephalus. Even though ciliary components and three master transcriptional regulators
O'Brien, T., Lalor, P., Fitzgerald, U., Liu, M., Guan, Z., Shen, S., Shen, Q., Dockery, P.   +7 more
core   +4 more sources

Probing ciliogenesis using micropatterned substrates. [PDF]

, 2013
International audienceThe primary cilium is a biomechanical sensor plugged in at the cell surface. It is implicated in the processing of extracellular signals and its absence or misfunctioning lead to a broad variety of serious defects known as ...
Curtet, Alexis, Amandine Pitaval, Christ, Andreas, Andreas Christ, Alexis Curtet, Théry, Manuel, Pitaval, Amandine, Tseng, Qingzong, Qingzong Tseng, Manuel Théry   +9 more
core   +6 more sources

Roles for ELMOD2 and Rootletin in ciliogenesis [PDF]

Molecular Biology of the Cell, 2021
The ARF GAP ELMOD2, Rootletin, and ARL2 all act in a common pathway to suppress spurious ciliation upstream of CP110 and to maintain centrosome cohesion.
Turn, Rachel E., Linnert, Joshua, Gigante, Eduardo D., Wolfrum, Uwe, Caspary, Tamara, Kahn, Richard A.   +5 more
openaire   +3 more sources

Autophagy and Ciliogenesis

JMA Journal, 2021
Autophagy is a major intracellular degradation system and plays important roles in various physiological processes such as metabolic adaptation and intracellular homeostasis. It degrades intracellular components both randomly and selectively. Autophagic activity is tightly regulated primarily by nutrient availability, but also by other extracellular ...
Yamamoto, Yasuhiro, Mizushima, Noboru
openaire   +2 more sources