Results 11 to 20 of about 17,107 (226)
TRIP6 functions in brain ciliogenesis [PDF]
Nature Communications, 2021 AbstractTRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion component.Trip6deletion in the mouse, reported here, reveals a function in the brain: ependymal and choroid plexus epithelial cells are carrying, unexpectedly, fewer and shorter cilia, are poorly differentiated, and the mice develop hydrocephalus.
Shalmali Shukla +13 more
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JMA Journal, 2021 Autophagy is a major intracellular degradation system and plays important roles in various physiological processes such as metabolic adaptation and intracellular homeostasis. It degrades intracellular components both randomly and selectively. Autophagic activity is tightly regulated primarily by nutrient availability, but also by other extracellular ...
Yamamoto, Yasuhiro, Mizushima, Noboru
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Mechanobiology of Ciliogenesis [PDF]
BioScience, 2014 Cilia are force-generating and -sensing organelles that serve as mechanical interfaces between the cell and the extracellular environment. Cilia are present in tissues that adaptively respond to mechanical loading and fluid flow, and defects in ciliary function can lead to diseases affecting these tissues.
Ishikawa, Hiroaki, Marshall, Wallace F
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Ciliogenesis membrane dynamics and organization
Seminars in Cell & Developmental Biology, 2023 Ciliogenesis is a complex multistep process used to describe assembly of cilia and flagella. These organelles play essential roles in motility and signaling on the surface of cells. Cilia are built at the distal ends of centrioles through the formation of an axoneme that is surrounded by the ciliary membrane.
Huijie, Zhao +2 more
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Molecular Brain, 2023 The primary cilium, an antenna-like structure on the cell surface, acts as a mechanical and chemical sensory organelle. Primary cilia play critical roles in sensing the extracellular environment to coordinate various developmental and homeostatic ...
Ji-Eun Bae +17 more
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A meckelin–filamin A interaction mediates ciliogenesis [PDF]
Human Molecular Genetics, 2011 MKS3, encoding the transmembrane receptor meckelin, is mutated in Meckel-Gruber syndrome (MKS), an autosomal-recessive ciliopathy. Meckelin localizes to the primary cilium, basal body and elsewhere within the cell. Here, we found that the cytoplasmic domain of meckelin directly interacts with the actin-binding protein filamin A, potentially at the ...
Adams, M. +13 more
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Roles for ELMOD2 and Rootletin in ciliogenesis [PDF]
Molecular Biology of the Cell, 2021 The ARF GAP ELMOD2, Rootletin, and ARL2 all act in a common pathway to suppress spurious ciliation upstream of CP110 and to maintain centrosome cohesion.
Turn, Rachel E. +5 more
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Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation.
PLoS ONE, 2017 Primary cilia are non-motile cilia that serve as cellular antennae for sensing and transducing extracellular signals. In general, primary cilia are generated by cell quiescence signals.
Tomoaki Nagai, Kensaku Mizuno
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Cell Reports, 2020 Summary: Primary cilium is an antenna-like microtubule-based cellular sensing structure. Abnormal regulation of the dynamic assembly and disassembly cycle of primary cilia is closely related to ciliopathy and cancer.
Mi-Lang Kyun +10 more
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Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]
, 2016 The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina +8 more
core +2 more sources