Results 1 to 10 of about 10,445 (178)

Experimental and Natural Induction of de novo Centriole Formation

Frontiers in Cell and Developmental Biology, 2022
In cycling cells, new centrioles are assembled in the vicinity of pre-existing centrioles. Although this canonical centriole duplication is a tightly regulated process in animal cells, centrioles can also form in the absence of pre-existing centrioles ...
Daiju Kitagawa
exaly   +3 more sources

Rapid Evolution of Sperm Produces Diverse Centriole Structures that Reveal the Most Rudimentary Structure Needed for Function

Cells, 2018
Centrioles are ancient subcellular protein-based organelles that maintain a conserved number and structure across many groups of eukaryotes. Centriole number (two per cells) is tightly regulated; each pre-existing centriole nucleates only one centriole ...
Tomer Avidor-Reiss
exaly   +3 more sources

McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation [PDF]

EMBO Reports
The centriole duplication cycle must be tightly controlled and coordinated with the chromosome cycle. Aberrations in centriole biogenesis can cause developmental disorders, ciliopathies and cancer, yet the molecular determinants controlling centriole ...
Marina Arbi, Margarita Skamnelou, Lydia Koufoudaki, Vasiliki Bakali, Spyridoula Bournaka, Sihem Zitouni, Stavroula Tsaridou, Ozge Karayel, Catherine G Vasilopoulou, Aikaterini C Tsika, Nikolaos N Giakoumakis, Ourania Preza, Georgios A Spyroulias, Matthias Mann, Mónica Bettencourt-Dias, Stavros Taraviras, Zoi Lygerou   +16 more
doaj   +2 more sources

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies. [PDF]

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Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Frisby D, Misri G, Naslavsky N, Caplan S.   +3 more
europepmc   +2 more sources

The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number [PDF]

Open Biology, 2018
Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated.
Christian Arquint, Alexander Schmidt, Fabien Cubizolles   +2 more
exaly   +2 more sources

Multimodal mechanisms of human centriole engagement and disengagement

EMBO Journal
Centrioles are unique cellular structures that replicate to produce identical copies, ensuring accurate chromosome segregation during mitosis. A new centriole, the “daughter”, is assembled adjacent to an existing “mother” centriole.
Shohei Yamamoto, Daiju Kitagawa, Shoji Hata   +2 more
exaly   +2 more sources

Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1 [PDF]

Nature Communications
Centriole biogenesis is viewed as a template-free physical transformation where a cartwheel scaffold emerges to guide centriole growth and subsequently disassembles; however, the mechanism underlying cartwheel dynamics remains obscure.
Kanako Ozaki, Ting-Jui Ben Chang, Wen-Qing Yang, Avital Shulman, Denisse Izquierdo, Wann-Neng Jane, Won-Jing Wang, Tim Stearns, Jens Lüders, T. Tony Yang, Meng-Fu Bryan Tsou   +10 more
doaj   +2 more sources

Centriolar Protein POC5 Regulates Human Adipogenesis and Cellular Senescence: Insights From a Novel Metabolic Ciliopathy. [PDF]

FASEB J
The identification of a patient carrying a novel homozygous p.(Gln206Ter) POC5 variant revealed a metabolic phenotype associated with POC5 deficiency. POC5 deficiency disrupts centriolar architecture and ciliary organization, leading to impaired proliferation, premature cellular senescence, and reduced insulin signaling.
Pistorio V, Vatier C, Capel É, Beaupère C, Auclair M, Steunou V, Morichon R, Joubert M, Vigouroux C, Gautheron J, Jéru I.   +10 more
europepmc   +2 more sources

PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

eLife, 2022
Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro, Chelsea G Drown, Aubrey L Maryniak, Cayla E Jewett, Margaret A Strong, Andrew Jon Holland   +5 more
doaj   +1 more source

Building a centriole [PDF]

Current Opinion in Cell Biology, 2013
Centrioles are the key foundation of centrosomes and cilia, yet a molecular understanding of how they form has only recently begun to emerge. Building a fully functional centriole that can form a centrosome and cilium requires two cell cycles. Centriole building starts with procentriole nucleation, a process that is coordinated by the conserved ...
Tomer, Avidor-Reiss, Jayachandran, Gopalakrishnan   +1 more
openaire   +2 more sources