Results 1 to 10 of about 18,948 (224)

McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation [PDF]

EMBO Reports
The centriole duplication cycle must be tightly controlled and coordinated with the chromosome cycle. Aberrations in centriole biogenesis can cause developmental disorders, ciliopathies and cancer, yet the molecular determinants controlling centriole ...
Marina Arbi, Margarita Skamnelou, Lydia Koufoudaki, Vasiliki Bakali, Spyridoula Bournaka, Sihem Zitouni, Stavroula Tsaridou, Ozge Karayel, Catherine G Vasilopoulou, Aikaterini C Tsika, Nikolaos N Giakoumakis, Ourania Preza, Georgios A Spyroulias, Matthias Mann, Mónica Bettencourt-Dias, Stavros Taraviras, Zoi Lygerou   +16 more
doaj   +2 more sources

NuSAP Safeguards Centriole Integrity to Mediate CEP57-CEP152 Torus Recruitment for Proper Engagement. [PDF]

Adv Sci (Weinh)
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Zhang S, Jiang Z, Yang Q, Zheng H, Wang M, Zhu C, Deng LW, Crasta KC, Liou YC.   +8 more
europepmc   +2 more sources

C. elegans SSNA-1 is required for the structural integrity of centrioles and bipolar spindle assembly [PDF]

Nature Communications
Centrioles play key roles in mitotic spindle assembly. Once assembled, centrioles exhibit long-term stability, but how stability is achieved and how it is regulated are not completely understood.
Jason A. Pfister, Lorenzo Agostini, Lorène Bournonville, Aurélien Perrier, Prabhu Sankaralingam, Zachary G. Bell, Virginie Hamel, Paul Guichard, Christian Biertümpfel, Naoko Mizuno, Kevin F. O’Connell   +10 more
doaj   +2 more sources

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation. [PDF]

Cytoskeleton (Hoboken)
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Peneda C, Bugalhao JN, Louro MAD, Henriques-Soares A, Bettencourt-Dias M.   +4 more
europepmc   +2 more sources

Assembly and mother centriole recruitment of IFT-B subcomplexes to form IFT-B holocomplex [PDF]

Cell Structure and Function
For the biogenesis and maintenance of cilia, bidirectional protein trafficking within cilia is crucial, and is conducted by intraflagellar transport (IFT) trains containing the IFT-A and IFT-B complexes that are powered by dynein-2 and kinesin-II motors.
Koshi Tasaki, Yohei Katoh, Hye-Won Shin, Kazuhisa Nakayama   +3 more
doaj   +2 more sources

PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

eLife, 2022
Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro, Chelsea G Drown, Aubrey L Maryniak, Cayla E Jewett, Margaret A Strong, Andrew Jon Holland   +5 more
doaj   +1 more source

Centriole structure [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2014
Centrioles are among the largest protein-based structures found in most cell types, measuring approximately 250 nm in diameter and approximately 500 nm long in vertebrate cells. Here, we briefly review ultrastructural observations about centrioles and associated structures.
Winey, Mark, O'Toole, Eileen
openaire   +4 more sources

Experimental and Natural Induction of de novo Centriole Formation

Frontiers in Cell and Developmental Biology, 2022
In cycling cells, new centrioles are assembled in the vicinity of pre-existing centrioles. Although this canonical centriole duplication is a tightly regulated process in animal cells, centrioles can also form in the absence of pre-existing centrioles ...
Kasuga Takumi, Daiju Kitagawa
doaj   +1 more source

Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells

eLife, 2021
How cells count and regulate organelle number is a fundamental question in cell biology. For example, most cells restrict centrioles to two in number and assemble one cilium; however, multiciliated cells (MCCs) synthesize hundreds of centrioles to ...
Saurabh Kulkarni, Jonathan Marquez, Priya Date, Rosa Ventrella, Brian J Mitchell, Mustafa K Khokha   +5 more
doaj   +1 more source

CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. [PDF]

PLoS ONE, 2011
BACKGROUND: CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis.
Nathalie Franck, Emilie Montembault, Pierre Romé, Aude Pascal, Jean-Yves Cremet, Régis Giet   +5 more
doaj   +1 more source