Results 41 to 50 of about 13,342 (208)
Prion, 2008 Early cell biologists perceived centrosomes to be permanent cellular structures. Centrosomes were observed to reproduce once each cycle and to orchestrate assembly a transient mitotic apparatus that segregated chromosomes and a centrosome to each daughter at the completion of cell division.
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PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space [PDF]
, 2015 SummaryCentrioles are essential for cilia and centrosome assembly. In centriole-containing cells, centrioles always form juxtaposed to pre-existing ones, motivating a century-old debate on centriole biogenesis control.
Carla A.M. Lopes +25 more
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The Centriole’s Role in Miscarriages [PDF]
Frontiers in Cell and Developmental Biology, 2022 Centrioles are subcellular organelles essential for normal cell function and development; they form the cell’s centrosome (a major cytoplasmic microtubule organization center) and cilium (a sensory and motile hair-like cellular extension). Centrioles with evolutionarily conserved characteristics are found in most animal cell types but are absent in egg
Tomer Avidor-Reiss +4 more
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The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion [PDF]
, 2000 Duplicating centrosomes are paired during interphase, but are separated at the onset of mitosis. Although the mechanisms controlling centrosome cohesion and separation are important for centrosome function throughout the cell cycle, they remain poorly ...
Fry, A. M. +9 more
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Control of centriole numbers by Plk4 autophosphorylation and βTrCP-mediated degradation [PDF]
, 2010 Proper centrosome numbers are imperative for faithful cell division, as aberrant centrosome numbers can lead to chromosomal instability, a hallmark of cancer development (Nigg 2002; Ganem et al., 2009).
Guderian, Gernot
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Building the right centriole for each cell type [PDF]
, 2017 The deposited article version is the publisher version, which is in a "Epub Ahead of Print” state at the moment of the deposit.This deposit is composed by the main article, and it hasn't any supplementary materials associated.The centriole is a ...
Bettencourt-Dias, Mónica +3 more
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Molecular Mechanisms Controlling Centriole Duplication
, 2020 Centrioles are barrel shaped, non-membrane bound organelles that typically exist in pairs where the younger ‘daughter’ centriole emanates orthogonally off of the proximal end of the older ‘mother’ centriole.
Boese, Cody
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Open Biology, 2022 Centrosomes are important organizers of microtubules within animal cells. They comprise a pair of centrioles surrounded by the pericentriolar material, which nucleates and organizes the microtubules.
Neil H. J. Cunningham +2 more
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Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer
Cell Reports, 2017 Chromosomal instability is a hallmark of cancer and correlates with the presence of extra centrosomes, which originate from centriole overduplication. Overduplicated centrioles lead to the formation of centriole rosettes, which mature into supernumerary ...
Marco R. Cosenza +14 more
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PLoS Genetics, 2022 Centrioles are submicron-scale, barrel-shaped organelles typically found in pairs, and play important roles in ciliogenesis and bipolar spindle assembly.
Jyoti Iyer +10 more
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