Results 51 to 60 of about 10,058 (131)
Dynamic centriolar localization of Polo and Centrobin in early mitosis primes centrosome asymmetry.
PLoS Biology, 2020 Centrosomes, the main microtubule organizing centers (MTOCs) of metazoan cells, contain an older "mother" and a younger "daughter" centriole. Stem cells either inherit the mother or daughter-centriole-containing centrosome, providing a possible mechanism
Emmanuel Gallaud +8 more
doaj +1 more source
eLife, 2018 Centrosome structure, function, and number are finely regulated at the cellular level to ensure normal mammalian development. Here, we characterize PPP1R35 as a novel bona fide centrosomal protein and demonstrate that it is critical for centriole ...
Andrew Michael Sydor +6 more
doaj +1 more source
Cilia in Nervous System Development, Function, and Disease
MedComm – Future Medicine, Volume 5, Issue 2, June 2026.Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley +1 more source
Cell Reports, 2015 In animal cells, supernumerary centrosomes, resulting from centriole amplification, cause mitotic aberrations and have been associated with diseases, including microcephaly and cancer.
Edo Dzafic +3 more
doaj +1 more source
ChemBioChem, Volume 27, Issue 9, 14 May 2026.Monoclonal antibodies targeting the interdomain region of polo‐like kinase 1 (PLK1) were delivered into living HeLa cells by electroporation to directly modulate mitotic progression. This intracellular antibody approach provides a new tool to probe PLK1 function and highlights the potential of antibodies to regulate key mitotic regulators inside cells.
Clément Steyer +5 more
wiley +1 more source
Production of Basal Bodies in bulk for dense multicilia formation [version 1; referees: 2 approved]
F1000Research, 2016 Centriole number is normally under tight control and is directly linked to ciliogenesis. In cells that use centrosomes as mitotic spindle poles, one pre-existing mother centriole is allowed to duplicate only one daughter centriole per cell cycle.
Xiumin Yan, Huijie Zhao, Xueliang Zhu
doaj +1 more source
Advanced Science, Volume 13, Issue 26, 8 May 2026.CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen +11 more
wiley +1 more source
Cell Reports, 2014 Vertebrate centrioles lose their geometric scaffold, the cartwheel, during mitosis, concurrently with gaining the ability to recruit the pericentriolar material (PCM) and thereby function as the centrosome.
Denisse Izquierdo +3 more
doaj +1 more source
The mother centriole plays an instructive role in defining cell geometry.
PLoS Biology, 2007 Centriole positioning is a key step in establishment and propagation of cell geometry, but the mechanism of this positioning is unknown. The ability of pre-existing centrioles to induce formation of new centrioles at a defined angle relative to ...
Jessica L Feldman +2 more
doaj +1 more source
Atypical Centrioles During Sexual Reproduction
Frontiers in Cell and Developmental Biology, 2015 Centrioles are conserved, self-replicating, microtubule-based 9-fold symmetric subcellular organelles that are essential for proper cell division and function.
Tomer eAvidor-Reiss +3 more
doaj +1 more source