Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer [PDF]
Cells, 2022 Centrosomes nucleate and anchor microtubules and therefore play major roles in spindle formation and chromosome segregation during mitosis. Duplication of the centrosome occurs, similar to DNA, only once during the cell cycle.
Íngrid Hoffmann, Hoffmann Íngrid
exaly +4 more sources
Interactions of N- and C-terminal parts of Ana1 permitting centriole duplication but not elongation [PDF]
Open BiologyThe conserved process of centriole duplication requires the establishment of a Sas6-centred cartwheel initiated by Plk4’s phosphorylation of Ana1/STIL.
Jingyan Fu +2 more
exaly +5 more sources
Spermatocytes have the capacity to segregate chromosomes despite centriole duplication failure [PDF]
EMBO ReportsCentrosomes are the canonical microtubule organizing centers (MTOCs) of most mammalian cells, including spermatocytes. Centrosomes comprise a centriole pair within a structurally ordered and dynamic pericentriolar matrix (PCM).
Pablo Lopez-Jimenez +2 more
exaly +3 more sources
Self-organization of Plk4 regulates symmetry breaking in centriole duplication [PDF]
Nature Communications, 2019 During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation ...
Shohei Yamamoto +2 more
exaly +3 more sources
Centriole Duplication at the Crossroads of Cell Cycle Control and Oncogenesis [PDF]
CellsCentriole duplication is a vital process for cellular organisation and function, underpinning essential activities such as cell division, microtubule organisation and ciliogenesis.
Claude Prigent
doaj +2 more sources
The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number [PDF]
Open Biology, 2018 Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated.
Christian Arquint +2 more
exaly +2 more sources
The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication [PDF]
eLife, 2021 The duplication and ninefold symmetry of the Drosophila centriole requires that the cartwheel molecule, Sas6, physically associates with Gorab, a trans-Golgi component. How Gorab achieves these disparate associations is unclear.
Agnieszka Fatalska +8 more
doaj +2 more sources
Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication [PDF]
Cell Reports, 2018 Summary: The protein deacetylase SIRT1 (Sirtuin 1) regulates many cellular processes, including cell-cycle progression, DNA damage response, and metabolism. Although the centrosome is a key regulator of cell-cycle progression and genome stability, little
Hongbo Ling +4 more
doaj +2 more sources
Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. [PDF]
PLoS Genetics, 2017 In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, therefore appropriate regulation of centriole duplication is critical. The C.
Nina Peel +5 more
doaj +2 more sources
CRL4 DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent premature centriole duplication [PDF]
Life Science AllianceThis study identifies the E3 ubiquitin ligase, CRL4DCAF1, as a new regulator of polo-like kinase 4, PLK4, protein levels in the G2 phase of the cell cycle to prevent premature duplication of centrioles.
Josina Grossmann +4 more
doaj +2 more sources