Results 41 to 50 of about 83,983 (175)

PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

eLife, 2022
Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro, Chelsea G Drown, Aubrey L Maryniak, Cayla E Jewett, Margaret A Strong, Andrew Jon Holland   +5 more
doaj   +1 more source

STIL is required for centriole duplication in human cells [PDF]

Journal of Cell Science, 2012
Centrioles are key structural elements of centrosomes and primary cilia. In mammals, only a few proteins including PLK4, CPAP (CENPJ), SAS6, CEP192, CEP152 and CEP135 have thus far been identified to be required for centriole duplication. STIL (SCL/TAL1 interrupting locus, also known as SIL) is a centrosomal protein that is essential for mouse and ...
Julia, Vulprecht, Ahuvit, David, Alexandra, Tibelius, Asher, Castiel, Gleb, Konotop, Fengying, Liu, Felix, Bestvater, Marc S, Raab, Hanswalter, Zentgraf, Shai, Izraeli, Alwin, Krämer   +10 more
openaire   +2 more sources

Rootletin forms centriole-associated filaments and functions in centrosome cohesion [PDF]

, 2005
After duplication of the centriole pair during S phase, the centrosome functions as a single microtubule-organizing center until the onset of mitosis, when the duplicated centrosomes separate for bipolar spindle formation.
Erich A. Nigg, Stierhof, Y. D., Stierhof, York-Dieter, Wilkinson, Christopher J., Nigg, E. A., Wilkinson, C. J., Bahe, S., Leiss, F., Christopher J. Wilkinson, Florian Leiss, Leiss, Florian, Susanne Bahe, Bahe, Susanne, Nigg, Erich A., York-Dieter Stierhof   +14 more
core   +1 more source

Cep152 interacts with Plk4 and is required for centriole duplication [PDF]

Journal of Cell Biology, 2010
Centrioles are microtubule-based structures that organize the centrosome and nucleate cilia. Centrioles duplicate once per cell cycle, and duplication requires Plk4, a member of the Polo-like kinase family; however, the mechanism linking Plk4 activity and centriole formation is unknown. In this study, we show in human and frog cells that Plk4 interacts
Hatch, Emily M, Kulukian, Anita, Holland, Andrew J, Cleveland, Don W, Stearns, Tim   +4 more
openaire   +4 more sources

Investigating the cellular and molecular mechanisms involved in establishing and maintaining centrosome asymmetry in Drosophila neuroblasts [PDF]

, 2015
Centrosome asymmetry has been implicated in stem cell fate maintenance in both flies and vertebrates. Drosophila neuroblasts, the neural precursors of the fly’s central nervous system, contain molecularly and physically asymmetric centrosomes.
Nair, Anjana Ramdas
core   +1 more source

Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]

, 2009
Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Thomas H. Giddings, Mark Winey, Osborn, DP, Chad G. Pearson, Philip L. Beales, Beales, PL, Giddings, TH, Winey, M, Pearson, CG, Daniel P.S. Osborn   +9 more
core   +1 more source

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

eLife, 2015
Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. We found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the ...
Andrew Kodani, Timothy W Yu, Jeffrey R Johnson, Divya Jayaraman, Tasha L Johnson, Lihadh Al-Gazali, Lāszló Sztriha, Jennifer N Partlow, Hanjun Kim, Alexis L Krup, Alexander Dammermann, Nevan J Krogan, Christopher A Walsh, Jeremy F Reiter   +13 more
doaj   +1 more source

Shape And Copy Number Of Centriole Duplication

, 2016
Centrioles are microtubule-based, 9-fold symmetrical cylinder-like structures that duplicate exactly once per cell cycle. The 9-fold symmetry is defined by a geometric scaffold known as the cartwheel, upon which all centrioles are formed.
Kim, Minhee
core   +6 more sources

Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation

eLife, 2017
The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the ...
Kenji Sugioka, Danielle R Hamill, Joshua B Lowry, Marie E McNeely, Molly Enrick, Alyssa C Richter, Lauren E Kiebler, James R Priess, Bruce Bowerman   +8 more
doaj   +1 more source

Cep164, a novel centriole appendage protein required for primary cilium formation [PDF]

, 2007
Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and ...
Graser, Susanne, Erich A. Nigg, Gassner, Oliver S., Gassner, O. S., Susanne Graser, Stierhof, Y. D., Lavoie, S. B., Stierhof, York-Dieter, Nigg, E. A., Sébastien B. Lavoie, Le Clech, M., Stefan Lamla, Graser, S., Nigg, Erich A., Lavoie, Sébastien B., York-Dieter Stierhof, Le Clech, Mikael, Oliver S. Gassner, Mikael Le Clech, Lamla, S., Lamla, Stefan   +20 more
core   +1 more source