Centrioles: Duplicating Precariously [PDF]
Current Biology, 2007 To assemble a mitotic spindle and accurately segregate chromosomes to progeny, a cell needs to precisely regulate its centrosome number, a feat largely accomplished through the tight control of centriole duplication. Recent work showing that the overexpression of centriolar proteins can lead to the formation of multiple centrioles in the absence of pre-
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Investigation of human centrosomes - with a special focus on the function of Cep152 and Cep192 in centriole duplication [PDF]
, 2012 Centrioles are symmetrical, barrel-shaped, microtubule-based structures, that serve as building platforms for the formation of centrosomes and cilia. In dividing cells, they recruit a matrix of proteins called pericentriolar material (PCM) to form the ...
Sonnen, Katharina Friederike
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STIL binding to Polo-box 3 of PLK4 regulates centriole duplication [PDF]
, 2015 Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication.
Timm Maier +15 more
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GCP6 is a substrate of Plk4 and required for centriole duplication [PDF]
Journal of Cell Science, 2012 Centriole duplication occurs once per cell cycle and requires Plk4, a member of the Polo-like kinase family. A key component of the centrosome is the γ-tubulin ring complex (γ-TuRC) that nucleates microtubules. GCP6 is a member of the γ-TuRC, but its role in human cells and the regulation of its functions remain unclear.
Ramona, Bahtz +6 more
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Talpid3-binding centrosomal protein Cep120 is required for centriole duplication and proliferation of cerebellar granule neuron progenitors. [PDF]
PLoS ONE, 2014 Granule neuron progenitors (GNPs) are the most abundant neuronal type in the cerebellum. GNP proliferation and thus cerebellar development require Sonic hedgehog (Shh) secreted from Purkinje cells.
Chuanqing Wu +6 more
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On the regulation of centriole duplication in human cells : exploring the interactions of polo-like kinase 4 with the centrosomal proteins Cep192 and STIL [PDF]
, 2015 Centrioles duplicate once in each cell cycle to give rise to two centrosomes that form the spindle poles during mitosis. Aberrant centriole duplication can result in the formation of supernumerary centrosomes, leading to incorrect spindle assembly and ...
Gabryjonczyk, Anna-Maria
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PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells
eLife, 2022 Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro +5 more
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Rootletin forms centriole-associated filaments and functions in centrosome cohesion [PDF]
, 2005 After duplication of the centriole pair during S phase, the centrosome functions as a single microtubule-organizing center until the onset of mitosis, when the duplicated centrosomes separate for bipolar spindle formation.
Erich A. Nigg +14 more
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Investigating the cellular and molecular mechanisms involved in establishing and maintaining centrosome asymmetry in Drosophila neuroblasts [PDF]
, 2015 Centrosome asymmetry has been implicated in stem cell fate maintenance in both flies and vertebrates. Drosophila neuroblasts, the neural precursors of the fly’s central nervous system, contain molecularly and physically asymmetric centrosomes.
Nair, Anjana Ramdas
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STIL is required for centriole duplication in human cells [PDF]
Journal of Cell Science, 2012 Centrioles are key structural elements of centrosomes and primary cilia. In mammals, only a few proteins including PLK4, CPAP (CENPJ), SAS6, CEP192, CEP152 and CEP135 have thus far been identified to be required for centriole duplication. STIL (SCL/TAL1 interrupting locus, also known as SIL) is a centrosomal protein that is essential for mouse and ...
Julia, Vulprecht +10 more
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