Results 51 to 60 of about 3,996 (179)
Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]
, 2009 Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Thomas H. Giddings +9 more
core +1 more source
Cep164, a novel centriole appendage protein required for primary cilium formation [PDF]
, 2007 Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and ...
Graser, Susanne +20 more
core +1 more source
eLife, 2017 The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the ...
Kenji Sugioka +8 more
doaj +1 more source
Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates [PDF]
, 2012 Protein kinases are important regulators of signal transduction pathways in both unicellular and multicellular organisms. They play critical roles in biological processes such as cell growth, division, differentiation, adhesion, motility and cell death ...
Kohler, Reto
core +1 more source
The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion [PDF]
, 2000 Duplicating centrosomes are paired during interphase, but are separated at the onset of mitosis. Although the mechanisms controlling centrosome cohesion and separation are important for centrosome function throughout the cell cycle, they remain poorly ...
Fry, A. M. +9 more
core +1 more source
Centrin Regulates Centriole Duplication [PDF]
Microscopy and Microanalysis, 2006 Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3 ...
openaire +1 more source
Experimental and Natural Induction of de novo Centriole Formation
Frontiers in Cell and Developmental Biology, 2022 In cycling cells, new centrioles are assembled in the vicinity of pre-existing centrioles. Although this canonical centriole duplication is a tightly regulated process in animal cells, centrioles can also form in the absence of pre-existing centrioles ...
Kasuga Takumi, Daiju Kitagawa
doaj +1 more source
SAS-6 Assembly Templated by the Lumen of Cartwheel-less Centrioles Precedes Centriole Duplication [PDF]
Developmental Cell, 2014 Centrioles are 9-fold symmetric structures duplicating once per cell cycle. Duplication involves self-oligomerization of the centriolar protein SAS-6, but how the 9-fold symmetry is invariantly established remains unclear. Here, we found that SAS-6 assembly can be shaped by preexisting (or mother) centrioles.
Fong, Chii Shyang +4 more
openaire +3 more sources
Centriole duplication and maturation in animal cells
, 1999 Publisher Summary The functional role and structural features of the centriole and the molecular events underlying centriolar duplication and maturation are discussed in the chapter. The published data are reviewed, with emphasis on the centriole of mammalian cells.
Lange, B, Faragher, A, March, P, Gull, K
openaire +2 more sources
Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication [PDF]
The Journal of Cell Biology, 2008 Centrosome duplication is tightly controlled in coordination with DNA replication. The molecular mechanism of centrosome duplication remains unclear. Previous studies found that a fraction of human proline-directed phosphatase Cdc14B associates with centrosomes. However, Cdc14B's involvement in centrosome cycle control has never been explored. Here, we
Wu, Jun +6 more
openaire +2 more sources