Centrin Regulates Centriole Duplication [PDF]
Microscopy and Microanalysis, 2006 Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3 ...
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Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates [PDF]
, 2012 Protein kinases are important regulators of signal transduction pathways in both unicellular and multicellular organisms. They play critical roles in biological processes such as cell growth, division, differentiation, adhesion, motility and cell death ...
Kohler, Reto
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Cell Cycle-Dependent Regulation of Centriole Duplication
, 2013 Centrosomes are organelles that promote microtubule growth. Normally, a single centrosome duplicates once each cell cycle to guide assembly of a bipolar mitotic spindle, ensuring that each daughter cell inherits an equal complement of the genome and a ...
Brownlee, Christopher William
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The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion [PDF]
, 2000 Duplicating centrosomes are paired during interphase, but are separated at the onset of mitosis. Although the mechanisms controlling centrosome cohesion and separation are important for centrosome function throughout the cell cycle, they remain poorly ...
Fry, A. M. +9 more
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Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication [PDF]
The Journal of Cell Biology, 2008 Centrosome duplication is tightly controlled in coordination with DNA replication. The molecular mechanism of centrosome duplication remains unclear. Previous studies found that a fraction of human proline-directed phosphatase Cdc14B associates with centrosomes. However, Cdc14B's involvement in centrosome cycle control has never been explored. Here, we
Wu, Jun +6 more
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C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 [PDF]
, 1998 Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans.
Fry, A. M. +17 more
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Experimental and Natural Induction of de novo Centriole Formation
Frontiers in Cell and Developmental Biology, 2022 In cycling cells, new centrioles are assembled in the vicinity of pre-existing centrioles. Although this canonical centriole duplication is a tightly regulated process in animal cells, centrioles can also form in the absence of pre-existing centrioles ...
Kasuga Takumi, Daiju Kitagawa
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Centriole duplication and maturation in animal cells
, 1999 Publisher Summary The functional role and structural features of the centriole and the molecular events underlying centriolar duplication and maturation are discussed in the chapter. The published data are reviewed, with emphasis on the centriole of mammalian cells.
Lange, B, Faragher, A, March, P, Gull, K
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The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries [PDF]
Nature Cell Biology, 2011 Centrosomes are microtubule-organizing centres of animal cells. They influence the morphology of the microtubule cytoskeleton, function as the base for the primary cilium and serve as a nexus for important signalling pathways. At the core of a typical centrosome are two cylindrical microtubule-based structures termed centrioles, which recruit a matrix ...
Nigg, Erich A., Stearns, Tim
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SAK/PLK4 Is Required for Centriole Duplication and Flagella Development [PDF]
Current Biology, 2005 SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK+/- mice develop liver and lung tumors and SAK+/- MEFs show mitotic abnormalities. However, the mechanism underlying these phenotypes is still not known.Here, we show that downregulation of SAK in Drosophila cells, by mutation or RNAi, leads ...
BETTENCOURT DIAS M. +9 more
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