Interaction interface in the C-terminal parts of centriole proteins Sas6 and Ana2 [PDF]
Open Biology, 2020 The centriole is a ninefold symmetrical structure found at the core of centrosomes and, as a basal body, at the base of cilia, whose conserved duplication is regulated by Plk4 kinase.
Agnieszka Fatalska +2 more
exaly +7 more sources
Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation [PDF]
Open Biology, 2017 The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans).
Nikola S Dzhindzhev +2 more
exaly +7 more sources
Drosophila Alms1 proteins regulate centriolar cartwheel assembly by enabling Plk4-Ana2 amplification loop [PDF]
EMBO JournalCentrioles play a central role in cell division by recruiting pericentriolar material (PCM) to form the centrosome. Alterations in centriole number or function lead to various diseases including cancer or microcephaly.
Marine Brunet +2 more
exaly +6 more sources
Centriole growth is limited by the Cdk/Cyclin-dependent phosphorylation of Ana2/STIL [PDF]
Journal of Cell Biology, 2022 Steinacker, Wong et al. show that centriole assembly in early fly embryos is not limited by a limiting pool of building blocks, but that phosphorylation of the centriole assembly protein Ana2/STIL by Cdk/Cyclins appears to slow centriole assembly toward ...
Thomas L Steinacker +2 more
exaly +5 more sources
A molecular mechanism for the procentriole recruitment of Ana2 [PDF]
Journal of Cell Biology, 2020 Centriole duplication begins with the assembly of a pre-procentriole at a single site on a mother centriole and proceeds with the hierarchical recruitment of a conserved set of proteins, including Polo-like kinase 4 (Plk4)/ZYG-1, Ana2/SAS-5/STIL, and the
Tiffany A Mclamarrah +2 more
exaly +8 more sources
An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly [PDF]
Journal of Cell Biology, 2018 Polo-like kinase 4 (Plk4) initiates an early step in centriole assembly by phosphorylating Ana2/STIL, a structural component of the procentriole. Here, we show that Plk4 binding to the central coiled-coil (CC) of Ana2 is a conserved event, involving Polo-
Tiffany A Mclamarrah +2 more
exaly +6 more sources
Author Correction: Drosophila Alms1 proteins regulate centriolar cartwheel assembly by enabling Plk4-Ana2 amplification loop [PDF]
The EMBO JournalMarine Brunet +8 more
doaj +4 more sources
Centriole growth is not limited by a finite pool of components, but is limited by the Cdk1/Cyclin-dependent phosphorylation of Ana2/STIL [PDF]
bioRxiv, 2022 Centrioles duplicate once per cell cycle but it is unclear how daughter centrioles assemble at the right time and place and grow to the right size. Here we show that in early Drosophila embryos the cytoplasmic concentrations of the key centriole assembly
Steinacker TL +8 more
europepmc +3 more sources
Poc1B and Sas-6 Function Together during the Atypical Centriole Formation in Drosophila melanogaster [PDF]
Cells, 2019 Insects and mammals have atypical centrioles in their sperm. However, it is unclear how these atypical centrioles form. Drosophila melanogaster sperm has one typical centriole called the giant centriole (GC) and one atypical centriole called the proximal
Kyoung H. Jo +5 more
doaj +3 more sources
Biology Open, 2017 A small number of proteins form a conserved pathway of centriole duplication. In humans and flies, the binding of PLK4/Sak to STIL/Ana2 initiates daughter centriole assembly.
Matthew A Cottee +2 more
exaly +4 more sources