, 2020 The centriole is a ninefold symmetrical structure found at the core of centrosomes and, as a basal body, at the base of cilia, whose conserved duplication is regulated by Plk4 kinase. Plk4 phosphorylates a single serine residue at the N-terminus of Ana2 to promote Ana2's loading to the site of procentriole formation.
Fatalska, Agnieszka +3 more
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Cell Cycle-Dependent Regulation of Centriole Duplication
, 2013 Centrosomes are organelles that promote microtubule growth. Normally, a single centrosome duplicates once each cell cycle to guide assembly of a bipolar mitotic spindle, ensuring that each daughter cell inherits an equal complement of the genome and a ...
Brownlee, Christopher William
core +4 more sources
Structural and Functional Analysis of the Protein Network Controlling Centriole Biogenesis [PDF]
, 2017 Centrosomes function as microtubules organising centres in mitosis or as basal bodies in cilia and flagella formation. The duplication of centrioles, which are at the core of each centrosome, is tightly regulated and occurs only once per cell cycle ...
Schneider, Manuela Sandra
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Structural and Biochemical Analysis of Dynein Light Chain-Mediated Homodimerization of Cytoskeletal and Nuclear Pore Proteins [PDF]
, 2012 The dynein light chain, Lc8/Dyn2, is a ubiquitous protein that acts as a scaffold, binding to many different target proteins in various cellular contexts. Here we describe S.
Romes, Erin MacKenzie
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Elucidating the pathway of centrosome formation [PDF]
, 2013 Centrosomes are cellular organelles present in most animal cells, and are formed of two main components: the centrioles and the pericentriolar material (PCM).
Raff, Jordan W., Costa Vicente, Catarina
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The Fifth International Meeting of ISEV, ISEV2016, Rotterdam, The Netherlands, 4 – 7 May, 2016
, 2016 Journal of Extracellular Vesicles, Volume 5, Issue 1, January 2016.
wiley +1 more source
Examining molecular interactions and dynamics in centrosome and centriole assembly [PDF]
, 2018 Centrioles are cellular organelles that give rise to the centrosome, a structure composed of a pair of centrioles surrounded by pericentriolar material.
Lisa Gartenmann, Gartenmann, Lisa
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Andrographolide-based potential anti-inflammatory transcription inhibitors against nuclear factor NF-kappa-B p50 subunit (NF-κB p50): an integrated molecular and quantum mechanical approach. [PDF]
3 Biotech, 2023 Jain P, Sudandiradoss C.
europepmc +1 more source
A Structural Study of Conserved Centriole Duplication Machinery [PDF]
, 2014 Centrioles are microtubule-based cylindrical structures that act within organelles responsible for nucleating polarized microtubule networks. Centrioles have an inherent nine-fold radial symmetry with species-dependent dimensions.
Slevin, Lauren K.
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