A molecular mechanism for the procentriole recruitment of Ana2 [PDF]
Journal of Cell Biology, 2020 During centriole duplication, a preprocentriole forms at a single site on the mother centriole through a process that includes the hierarchical recruitment of a conserved set of proteins, including the Polo-like kinase 4 (Plk4), Ana2/STIL, and the ...
Brian J Galletta +2 more
exaly +8 more sources
The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies [PDF]
eLife, 2015 Sas-6 and Ana2/STIL proteins are required for centriole duplication and the homo-oligomerisation properties of Sas-6 help establish the ninefold symmetry of the central cartwheel that initiates centriole assembly. Ana2/STIL proteins are poorly conserved,
Matthew A Cottee +5 more
doaj +6 more sources
An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly [PDF]
Journal of Cell Biology, 2017 Polo-like kinase 4 (Plk4) initiates an early step in centriole assembly by phosphorylating Ana2/STIL, a structural component of the procentriole. Here, we show that Plk4 binding to the central coiled-coil (CC) of Ana2 is a conserved event, involving Polo-
Kevin C. Slep +10 more
core +3 more sources
An Ana2/Ctp/Mud complex regulates spindle orientation in Drosophila neuroblasts [PDF]
Developmental Cell, 2011 Drosophila neural stem cells, larval brain neuroblasts (NBs), align their mitotic spindles along the apical/basal axis during asymmetric cell division (ACD) to maintain the balance of self-renewal and differentiation.
Li, S. +39 more
core +5 more sources
Drosophila Sas-6, Ana2 and Sas-4 self-organise into macromolecular structures that can be used to probe centriole and centrosome assembly. [PDF]
J Cell Sci, 2020 Centriole assembly requires a small number of conserved proteins. The precise pathway of centriole assembly has been difficult to study, as the lack of any one of the core assembly proteins [Plk4, Ana2 (the homologue of mammalian STIL), Sas-6, Sas-4 ...
Gartenmann L +6 more
europepmc +6 more sources
Caracterización de la curva de lactancia de bovinos Siboney con modelos no lineales mixtos [PDF]
Revista Mexicana de Ciencias Pecuarias, 2016 En bovinos productores de leche la curva de lactancia (CL) se ha analizado con modelos no lineales (MNL), y recientemente se ha implementado la metodología de MNL mixtos.
Alejandro Palacios Espinosa +6 more
doaj +2 more sources
Caracterización del crecimiento de bovinos cebú en pruebas de comportamiento en pastoreo/Characterization of growth of Cebu cattle in testing performance on grazing [PDF]
Ecosistemas y Recursos Agropecuarios, 2017 El objetivo fue caracterizar el crecimiento de bovinos Cebú en pruebas de comportamiento en pastoreo. Se utilizaron 15 990 datos de peso vivo, tomados entre 150 y 630 d de edad, de 3 198 machos con cinco pesadas cada uno: 1) peso al destete (PD), 2 ...
Joel Domínguez-Viveros +7 more
doaj +2 more sources
Building the Drosophila centriole: a structural investigation of the centriolar Proteins SAS-6, SAS-4 and Ana2 [PDF]
, 2014 The centriole is a complex cylindrical assembly found in the cells of ciliated eukaryotes. It serves two important roles in the cell: templating the growth of cilia, and forming the basis of the centrosome, which is the major microtubule organising ...
Raff, Jordan W +2 more
core +3 more sources
A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies [PDF]
Biology Open, 2017 A small number of proteins form a conserved pathway of centriole duplication. In humans and flies, the binding of PLK4/Sak to STIL/Ana2 initiates daughter centriole assembly.
Matthew A. Cottee +3 more
doaj +2 more sources
Role of conserved STAN serines in Ana2 centrosomal localisation
, 2015 The centrosome, which acts as the main microtubules-organising centre in animal cells, presents two cylindrical structures in its core: the centrioles.
Sieber, Boris
core +3 more sources