Results 1 to 10 of about 5,067 (166)

STIL Acts as an Oncogenetic Driver in a Primary Cilia-Dependent Manner in Human Cancer

Frontiers in Cell and Developmental Biology, 2022
SCL/TAL1 Interrupting locus (STIL) is a ciliary-related gene involved in regulating the cell cycle and duplication of centrioles in dividing cells. STIL has been found disordered in multiple cancers and driven carcinogenesis.
Zikun Yang, Yuanjiong Qi, Zhu Jianqiang   +2 more
exaly   +3 more sources

STIL Endows Oncogenic and Stem-Like Attributes to Colorectal Cancer Plausibly by Shh and Wnt Signaling

Frontiers in Oncology, 2021
The discovery of a potent gene regulating tumorigenesis and drug resistance is of high clinical importance. STIL is an oncogene; however, its molecular associations and role in colorectal oncogenesis are unknown.
Tapas Pradhan, Vikas Kumar, Samu John
exaly   +3 more sources

Multi-omics analysis reveals the key role of STIL in Li-Fraumeni syndrome and osteosarcoma [PDF]

npj Precision Oncology
Li-Fraumeni syndrome (LFS), driven by germline TP53 mutations, confers a markedly elevated risk of osteosarcoma (OS), yet the mechanisms beyond TP53 remain insufficiently defined.
Yu Qiao, Jincen Hao, Fahu Yuan, Anna Curto-Vilalta, Long Tang, Rüdiger von Eisenhart-Rothe, Florian Hinterwimmer   +6 more
doaj   +2 more sources

Association of stromal tumor infiltrating lymphocytes and body mass index with prognosis in esophageal squamous cell carcinoma patients [PDF]

BMC Cancer
Background Driven by BMI-related metabolic dysregulation and chronic inflammation that affect immune cell infiltration and function, the prognostic value of stromal tumor-infiltrating lymphocytes (sTIL) in esophageal squamous cell carcinoma (ESCC) may be
Hao Dong, Yang Wang, Peipei Gao, Longqing Yao, Xiaorong Yang, Ziyu Yuan, Tiejun Zhang, Ming Lu, Weimin Ye, Xingdong Chen, Chen Suo   +10 more
doaj   +2 more sources

STIL facilitates the development and malignant progression of triple-negative breast cancer through activation of Fanconi anemia pathway via interacting with KLF16

Translational Oncology
Background: STIL is an important cell cycle-regulating protein specifically recruited to the mitotic centrosome to promote the replication of centrioles in dividing cells.
Jiyue Gao, Zhenlong Yu, Zuowei Zhao
exaly   +3 more sources

STIL Overexpression Is Associated with Chromosomal Numerical Abnormalities in Non-Small-Cell Lung Carcinoma Through Centrosome Amplification

Current Oncology
STIL is a regulatory protein essential for centriole biogenesis, and its dysregulation has been implicated in various diseases, including malignancies. However, its role in non-small-cell lung carcinoma (NSCLC) remains unclear. In this study, we examined
Hisami Kato, Hidetaka Yamada, Yasuhiro Sakai   +2 more
exaly   +3 more sources

Pathological complete response, histologic grade, and level of stromal tumor-infiltrating lymphocytes in ER + HER2- breast cancer [PDF]

Breast Cancer Research
Background Recent trials have integrated immune checkpoint inhibitors (ICIs) into neoadjuvant chemotherapy (NAC) in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer of histologic grade (
Seung Ho Baek, Min Ji Lee, Yoonwon Kook, Soong June Bae, Joon Jeong, Yoon Jin Cha, Sung Gwe Ahn   +6 more
doaj   +2 more sources

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics. [PDF]

Clin Transl Med
1. Lactate‐derived histone lactylation links glycolytic reprogramming to epigenetic regulation in female reproductive diseases. 2. In endometriosis, lactylation may promote inflammatory remodelling, immune dysregulation and ferroptosis resistance. 3. In PCOS, lactylation connects metabolic disturbance to granulosa‐cell dysfunction and hyperandrogenism.
Qiao J, Xiao Y, Cheng Y, Xu W, Shu J, Li S.   +5 more
europepmc   +2 more sources

Stil

Handelingen, 2012
Tjeu van Knippenberg
doaj   +6 more sources

Regulatory factor X‐5/SCL/TAL1 interruption site axis promotes aerobic glycolysis and hepatocellular carcinoma cell stemness [PDF]

Kaohsiung Journal of Medical Sciences
The incidence and development of various tumors, such as hepatocellular carcinoma (HCC), are linked to tumor stem cells. Although research has revealed how important SCL/TAL1 interruption site (STIL) is in many human tumors, the impact of STIL on HCC ...
Zhi‐Zhong Zhang, Zi‐Ming Wang, Hao‐Wen Zhang, Yan‐Xin Gong, Hao‐Ran Sun, Wei Zhang   +5 more
doaj   +2 more sources