Results 1 to 10 of about 33,880 (194)

STIL Acts as an Oncogenetic Driver in a Primary Cilia-Dependent Manner in Human Cancer

Frontiers in Cell and Developmental Biology, 2022
SCL/TAL1 Interrupting locus (STIL) is a ciliary-related gene involved in regulating the cell cycle and duplication of centrioles in dividing cells. STIL has been found disordered in multiple cancers and driven carcinogenesis.
Yuanjiong Qi
exaly   +3 more sources

STIL Endows Oncogenic and Stem-Like Attributes to Colorectal Cancer Plausibly by Shh and Wnt Signaling

Frontiers in Oncology, 2021
The discovery of a potent gene regulating tumorigenesis and drug resistance is of high clinical importance. STIL is an oncogene; however, its molecular associations and role in colorectal oncogenesis are unknown.
Vikas Kumar, Samu John, Tapas Pradhan
exaly   +3 more sources

The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number [PDF]

Open Biology, 2018
Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated.
Christian Arquint, Schmidt A, Fabien Cubizolles   +2 more
exaly   +2 more sources

Multi-omics analysis reveals the key role of STIL in Li-Fraumeni syndrome and osteosarcoma [PDF]

npj Precision Oncology
Li-Fraumeni syndrome (LFS), driven by germline TP53 mutations, confers a markedly elevated risk of osteosarcoma (OS), yet the mechanisms beyond TP53 remain insufficiently defined.
Yu Qiao, Jincen Hao, Fahu Yuan, Anna Curto-Vilalta, Long Tang, Rüdiger von Eisenhart-Rothe, Florian Hinterwimmer   +6 more
doaj   +2 more sources

Association of stromal tumor infiltrating lymphocytes and body mass index with prognosis in esophageal squamous cell carcinoma patients [PDF]

BMC Cancer
Background Driven by BMI-related metabolic dysregulation and chronic inflammation that affect immune cell infiltration and function, the prognostic value of stromal tumor-infiltrating lymphocytes (sTIL) in esophageal squamous cell carcinoma (ESCC) may be
Hao Dong, Yang Wang, Peipei Gao, Longqing Yao, Xiaorong Yang, Ziyu Yuan, Tiejun Zhang, Ming Lu, Weimin Ye, Xingdong Chen, Chen Suo   +10 more
doaj   +2 more sources

STIL facilitates the development and malignant progression of triple-negative breast cancer through activation of Fanconi anemia pathway via interacting with KLF16

Translational Oncology
Background: STIL is an important cell cycle-regulating protein specifically recruited to the mitotic centrosome to promote the replication of centrioles in dividing cells.
Zhenlong Yu, Zhao Zuowei, Jiyue Gao
exaly   +3 more sources

STIL Overexpression Is Associated with Chromosomal Numerical Abnormalities in Non-Small-Cell Lung Carcinoma Through Centrosome Amplification

Current Oncology
STIL is a regulatory protein essential for centriole biogenesis, and its dysregulation has been implicated in various diseases, including malignancies. However, its role in non-small-cell lung carcinoma (NSCLC) remains unclear. In this study, we examined
Yasuhiro Sakai, Kazuhito Fúnaì, Haruhiko Sugimura   +2 more
exaly   +3 more sources

Pathological complete response, histologic grade, and level of stromal tumor-infiltrating lymphocytes in ER + HER2- breast cancer [PDF]

Breast Cancer Research
Background Recent trials have integrated immune checkpoint inhibitors (ICIs) into neoadjuvant chemotherapy (NAC) in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer of histologic grade (
Seung Ho Baek, Min Ji Lee, Yoonwon Kook, Soong June Bae, Joon Jeong, Yoon Jin Cha, Sung Gwe Ahn   +6 more
doaj   +2 more sources

Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number

Cell Reports, 2018
Summary: The number of centrioles is tightly controlled to ensure bipolar spindle assembly, which is a prerequisite to maintain genome integrity. However, our understanding of the fundamental principle that governs the formation of a single procentriole ...
Daiju Kitagawa, Akatsuki Kimura, Koki Watanabe   +2 more
exaly   +3 more sources

Confocal chromatic sensor for displacement monitoring in research reactor [PDF]

EPJ Web of Conferences, 2021
Confocal chromatic microscopy is an optical technique allowing measuring displacement, thickness, and roughness with a sub-micrometric precision. Its operation principle is based on a wavelength encoding of the object position.
Agoyan Marion, Fourneau Gary, Cheymol Guy, Ladaci Ayoub, Maskrot Hicham, Destouches Christophe, Fourmentel Damien, Gérand Sébastien, Gaillard-Groléas Jérôme, Desjacques Matthieu, Girard Sylvain, Boukenter Aziz   +11 more
doaj   +1 more source