Results 61 to 70 of about 3,996 (179)

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries [PDF]

Nature Cell Biology, 2011
Centrosomes are microtubule-organizing centres of animal cells. They influence the morphology of the microtubule cytoskeleton, function as the base for the primary cilium and serve as a nexus for important signalling pathways. At the core of a typical centrosome are two cylindrical microtubule-based structures termed centrioles, which recruit a matrix ...
Nigg, Erich A., Stearns, Tim
openaire   +3 more sources

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 [PDF]

, 1998
Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans.
Fry, A. M., Erich A. Nigg, Stierhof, Y. D., Mayor, T., Y. D. Stierhof (7653686), Tanaka, K., Nigg, E. A., Meraldi, P., Thibault Mayor, A. M. Fry (7651490), E. A. Nigg (7651493), Kayoko Tanaka, Andrew M. Fry, P. Meraldi (7653683), K. Tanaka (1500880), Patrick Meraldi, York-Dieter Stierhof, T. Mayor (7653680)   +17 more
core   +1 more source

SAK/PLK4 Is Required for Centriole Duplication and Flagella Development [PDF]

Current Biology, 2005
SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK+/- mice develop liver and lung tumors and SAK+/- MEFs show mitotic abnormalities. However, the mechanism underlying these phenotypes is still not known.Here, we show that downregulation of SAK in Drosophila cells, by mutation or RNAi, leads ...
BETTENCOURT DIAS M., RODRIGUES MARTINS A., CARPENTER L., RIPARBELLI, MARIA GIOVANNA, LEHMANN L., GATT M. K., CARMO N., BALLOUX, CALLAINI, GIULIANO, GLOVER D. M.   +9 more
openaire   +5 more sources

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

With Age Comes Maturity: Biochemical and Structural Transformation of a Human Centriole in the Making

Cells, 2020
Centrioles are microtubule-based cellular structures present in most human cells that build centrosomes and cilia. Proliferating cells have only two centrosomes and this number is stringently maintained through the temporally and spatially controlled ...
Catherine Sullenberger, Alejandra Vasquez-Limeta, Dong Kong, Jadranka Loncarek   +3 more
doaj   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication.

The Journal of cell biology, 2005
In mammalian cells, the centrosome consists of a pair of centrioles and amorphous pericentriolar material. The pair of centrioles, which are the core components of the centrosome, duplicate once per cell cycle. Centrosomes play a pivotal role in orchestrating the formation of the bipolar spindle during mitosis.
Zou, Chaozhong, Li, Jun, Bai, Yujie, Gunning, William T., Wazer, David E., Band, Vimla, Gao, Qingshen   +6 more
openaire   +2 more sources

Polo-like kinase 4: the odd one out of the family

Cell Division, 2010
Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication.
Bornens Michel, Sillibourne James E
doaj   +1 more source

The PLK4-STIL-SAS-6 module at the core of centriole duplication. [PDF]

Biochem Soc Trans, 2016
Centrioles are microtubule-based core components of centrosomes and cilia. They are duplicated exactly once during S-phase progression. Central to formation of each new (daughter) centriole is the formation of a nine-fold symmetrical cartwheel structure ...
Arquint C, Nigg EA.
europepmc   +2 more sources

Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species

Andrology, EarlyView.
ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak, Brian J. Galletta, Nasser M. Rusan   +2 more
wiley   +1 more source