Results 81 to 90 of about 3,996 (179)
Self-organization of Plk4 regulates symmetry breaking in centriole duplication
, 2018 During centriole duplication, a single daughter centriole is formed near the mother centriole. The mechanism that determines a single duplication site is unknown.
Daiju Kitagawa, Shohei Yamamoto
core +1 more source
Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication. [PDF]
PLoS ONE, 2010 Duplication of the centrosome is well controlled during faithful cell division while deregulation of this process leads to supernumary centrosomes, chromosome missegregation and aneuploidy, a hallmark of many cancer cells.
Annekatrin Krause, Ingrid Hoffmann
doaj +1 more source
Photochemistry and Photobiology, Volume 102, Issue 3, Page 560-576, May/June 2026.Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye +5 more
wiley +1 more source
Nature Communications, 2023 A tight synchrony between the DNA and centrosome cycle is essential for genomic integrity. Centriole disengagement, which licenses centrosomes for duplication, occurs normally during mitotic exit. We recently demonstrated that mild DNA replication stress
Devashish Dwivedi +2 more
doaj +1 more source
LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation
Cytoskeleton, Volume 83, Issue 3, Page 128-139, March 2026.ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda +4 more
wiley +1 more source
The conversion of centrioles to centrosomes: essential coupling of duplication with segregation [PDF]
Journal of Cell Biology, 2011 Centrioles are self-reproducing organelles that form the core structure of centrosomes or microtubule-organizing centers (MTOCs). However, whether duplication and MTOC organization reflect innate activities of centrioles or activities acquired conditionally is unclear.
Wang, Won-Jing +3 more
openaire +2 more sources
Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis
Nature Communications, 2019 Regulation of centriole duplication is essential for normal chromosome segregation and the maintenance of genomic stability, and Polo-like kinase 4 (Plk4) is a known regulator with unclear mechanisms.
Jung-Eun Park +5 more
doaj +1 more source
Movement Disorders, Volume 41, Issue 3, Page 651-666, March 2026.Abstract Background Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to environmental pathogens, we studied responses to Pseudomonas aeruginosa (P.
Julian R. Mark +8 more
wiley +1 more source
PLoS ONE, 2015 A procentriole is assembled next to the mother centriole during S phase and remains associated until M phase. After functioning as a spindle pole during mitosis, the mother centriole and procentriole are separated at the end of mitosis.
Mi Young Seo, Wonyul Jang, Kunsoo Rhee
doaj +1 more source
Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next
Photochemistry and Photobiology, Volume 102, Issue 2, Page 276-289, March/April 2026.The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal +3 more
wiley +1 more source