Results 101 to 110 of about 83,983 (175)

Multinucleation in the Human Embryo's First Mitosis: Linking Spindle Geometry Defects, SAC Tolerance, Chromosome Segregation, and Nuclear Envelope Reassembly

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Multinucleation occurs at high frequency during the first mitosis of human embryos and is associated with impaired developmental potential. Our live‐imaging analyses showed that collapse of spindle geometry—such as low‐aspect ratio spindles and pole defocusing—correlates with multinucleation, yet molecular links from aberrant ...
Yuki Ono, Yukihiro Terada
wiley   +1 more source

The interrelationship between APC/C and Plk1 activities in centriole disengagement

Biology Open, 2012
Summary Mother–daughter centriole disengagement, the necessary first step in centriole duplication, involves Plk1 activity in early mitosis and separase activity after APC/C activity mediates securin degradation.
Toshiyuki Hatano, Greenfield Sluder
doaj   +1 more source

De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly

eLife, 2015
Vertebrate centrioles normally propagate through duplication, but in the absence of preexisting centrioles, de novo synthesis can occur. Consistently, centriole formation is thought to strictly rely on self-assembly, involving self-oligomerization of the
Won-Jing Wang, Devrim Acehan, Chien-Han Kao, Wann-Neng Jane, Kunihiro Uryu, Meng-Fu Bryan Tsou   +5 more
doaj   +1 more source

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

eLife, 2013
Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required
Matthew A Cottee, Nadine Muschalik, Yao Liang Wong, Christopher M Johnson, Steven Johnson, Antonina Andreeva, Karen Oegema, Susan M Lea, Jordan W Raff, Mark van Breugel   +9 more
doaj   +1 more source

Role of CAP350 in centriolar tubule stability and centriole assembly.

PLoS ONE, 2008
BackgroundCentrioles are microtubule-based cylindrical structures composed of nine triplet tubules and are required for the formation of the centrosome, flagella and cilia. Despite theirs importance, centriole biogenesis is poorly understood.
Mikael Le Clech
doaj   +1 more source

Drosophila Alms1 proteins regulate centriolar cartwheel assembly by enabling Plk4-Ana2 amplification loop

The EMBO Journal
Centrioles play a central role in cell division by recruiting pericentriolar material (PCM) to form the centrosome. Alterations in centriole number or function lead to various diseases including cancer or microcephaly.
Marine Brunet, Joëlle Thomas, Jean-André Lapart, Léo Krüttli, Marine H Laporte, Maria Giovanna Riparbelli, Giuliano Callaini, Bénédicte Durand, Véronique Morel   +8 more
doaj   +1 more source

Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication [PDF]

, 2014
SummaryThe centrosome consists of a pair of centrioles and surrounding pericentriolar material (PCM). Many vertebrate cells also have an array of granules, termed centriolar satellites, that localize around the centrosome and are associated with ...
Yates, John R., Stearns, Tim, Firat-Karalar, Elif Nur, Rauniyar, Navin   +3 more
core   +1 more source

A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies

Biology Open, 2017
A small number of proteins form a conserved pathway of centriole duplication. In humans and flies, the binding of PLK4/Sak to STIL/Ana2 initiates daughter centriole assembly.
Matthew A. Cottee, Steven Johnson, Jordan W. Raff, Susan M. Lea   +3 more
doaj   +1 more source

The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

eLife, 2015
Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic ...
Kacper B Rogala, Nicola J Dynes, Georgios N Hatzopoulos, Jun Yan, Sheng Kai Pong, Carol V Robinson, Charlotte M Deane, Pierre Gönczy, Ioannis Vakonakis   +8 more
doaj   +1 more source

A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly. [PDF]

PLoS Biol, 2023
Wilmott ZM, Goriely A, Raff JW.
europepmc   +1 more source