Results 101 to 110 of about 3,996 (179)
When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination
BioEssays, Volume 47, Issue 11, November 2025.Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Cornelia Sala, Elmar Schiebel
wiley +1 more source
Mechanisms of Centriole Duplication and Spindle Assembly in Human Cells
, 2019 The centrosome is the major microtubule-organizing center in animal cells. Centrosomes duplicate once and only once per cell cycle thereby ensuring that two centrosomes are present in mitosis, each of them organizing one of the two spindle poles ...
Wu, Qianzhu
core +1 more source
Vesicular trafficking plays a role in centriole disengagement and duplication
Molecular Biology of the Cell, 2018 Centrosomes are the major microtubule-nucleating and microtubule-organizing centers of cells and play crucial roles in microtubule anchoring, organelle positioning, and ciliogenesis. At the centrosome core lies a tightly associated or “engaged” mother–daughter centriole pair.
Xie, Shuwei +9 more
openaire +2 more sources
De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly
eLife, 2015 Vertebrate centrioles normally propagate through duplication, but in the absence of preexisting centrioles, de novo synthesis can occur. Consistently, centriole formation is thought to strictly rely on self-assembly, involving self-oligomerization of the
Won-Jing Wang +5 more
doaj +1 more source
Characterization of the RhoGAP proteins RGA-3 and RGA-4 and the centrosomal protein SAS-5 in the early "Caenorhabditis elegans" embryo [PDF]
, 2007 The Caenorhabditis elegans embryo serves as a great tool to study cell biological processes like polarization and cell divison. The first cell division is unequal and cell polarization is dependant on the Rho GTPase regulated rearrangement of the cell ...
Schmutz, Cornelia
core +1 more source
eLife, 2013 Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required
Matthew A Cottee +9 more
doaj +1 more source
Role of CAP350 in centriolar tubule stability and centriole assembly.
PLoS ONE, 2008 BackgroundCentrioles are microtubule-based cylindrical structures composed of nine triplet tubules and are required for the formation of the centrosome, flagella and cilia. Despite theirs importance, centriole biogenesis is poorly understood.
Mikael Le Clech
doaj +1 more source
Molecular Mechanisms Controlling Centriole Duplication
, 2020 Centrioles are barrel shaped, non-membrane bound organelles that typically exist in pairs where the younger ‘daughter’ centriole emanates orthogonally off of the proximal end of the older ‘mother’ centriole.
Boese, Cody
core
Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication
, 2014 SummaryThe centrosome consists of a pair of centrioles and surrounding pericentriolar material (PCM). Many vertebrate cells also have an array of granules, termed centriolar satellites, that localize around the centrosome and are associated with ...
Yates, John R. +3 more
core +1 more source
Cell Cycle-Dependent Regulation of Centriole Duplication
, 2013 Centrosomes are organelles that promote microtubule growth. Normally, a single centrosome duplicates once each cell cycle to guide assembly of a bipolar mitotic spindle, ensuring that each daughter cell inherits an equal complement of the genome and a ...
Brownlee, Christopher William
core