Results 111 to 120 of about 3,996 (179)

A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies

Biology Open, 2017
A small number of proteins form a conserved pathway of centriole duplication. In humans and flies, the binding of PLK4/Sak to STIL/Ana2 initiates daughter centriole assembly.
Matthew A. Cottee, Steven Johnson, Jordan W. Raff, Susan M. Lea   +3 more
doaj   +1 more source

A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly. [PDF]

PLoS Biol, 2023
Wilmott ZM, Goriely A, Raff JW.
europepmc   +1 more source

Drosophila Alms1 proteins regulate centriolar cartwheel assembly by enabling Plk4-Ana2 amplification loop

The EMBO Journal
Centrioles play a central role in cell division by recruiting pericentriolar material (PCM) to form the centrosome. Alterations in centriole number or function lead to various diseases including cancer or microcephaly.
Marine Brunet, Joëlle Thomas, Jean-André Lapart, Léo Krüttli, Marine H Laporte, Maria Giovanna Riparbelli, Giuliano Callaini, Bénédicte Durand, Véronique Morel   +8 more
doaj   +1 more source

The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

eLife, 2015
Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic ...
Kacper B Rogala, Nicola J Dynes, Georgios N Hatzopoulos, Jun Yan, Sheng Kai Pong, Carol V Robinson, Charlotte M Deane, Pierre Gönczy, Ioannis Vakonakis   +8 more
doaj   +1 more source

Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells. [PDF]

Commun Biol, 2023
Il Ahn J, Zhang L, Ravishankar H, Fan L, Kirsch K, Zeng Y, Meng L, Park JE, Yun HY, Ghirlando R, Ma B, Ball D, Ku B, Nussinov R, Schmit JD, Heinz WF, Kim SJ, Karpova T, Wang YX, Lee KS.   +19 more
europepmc   +1 more source

Centriole assembly and the role of Mps1: defensible or dispensable?

Cell Division, 2011
The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C.
Fisk Harold A, Pike Amanda N
doaj   +1 more source

Author Correction: Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells. [PDF]

Commun Biol, 2023
Il Ahn J, Zhang L, Ravishankar H, Fan L, Kirsch K, Zeng Y, Meng L, Park JE, Yun HY, Ghirlando R, Ma B, Ball D, Ku B, Nussinov R, Schmit JD, Heinz WF, Kim SJ, Karpova T, Wang YX, Lee KS.   +19 more
europepmc   +1 more source

GORAB, a Golgi protein required for centriole structure and duplication

, 2017
Genome wide screens are widely believed to have identified the great majority of genes required for centriole duplication. However, seeking to clarify the partners of the Drosophila cartwheel protein Sas6, we identified Gorab, a known trans-Golgi ...
David M. Glover, Sandra Schneider, Maria Giovanna Riparbelli, George Tzolovsky, Giuliano Callaini, Nikola S. Dzhindzhev, Jennifer Chao-Chu, Levente Kovacs, Marco Gottardo   +8 more
core   +1 more source

The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication

Nature Communications
Copy number control of DNA and centrosomes is essential for accurate genetic inheritance. DNA replication and centrosome duplication have been recognized as parallel key events for cell division.
Kyohei Matsuhashi, Kei K. Ito, Kaho Nagai, Akira Sanada, Koki Watanabe, Kasuga Takumi, Atsushi Toyoda, Masamitsu Fukuyama, Shohei Yamamoto, Takumi Chinen, Grant S. Stewart, Shoji Hata, Daiju Kitagawa   +12 more
doaj   +1 more source

CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72. [PDF]

BMC Biol, 2022
Ying Z, Wang K, Wu J, Wang M, Yang J, Wang X, Zhou G, Chen H, Xu H, Sze SCW, Gao F, Li C, Sha O.   +12 more
europepmc   +1 more source